Tom Roques
A5009387241- Head and Neck Cancer Studies
- Cancer Genomics and Diagnostics
- Advances in Oncology and Radiotherapy
- Advanced Radiotherapy Techniques
- Cancer Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Head and Neck Surgical Oncology
- Economic and Financial Impacts of Cancer
- Pancreatic and Hepatic Oncology Research
- Tumors and Oncological Cases
- Bioinformatics and Genomic Networks
- Evolution and Genetic Dynamics
- Radiomics and Machine Learning in Medical Imaging
- Genomics and Phylogenetic Studies
- Genomics and Chromatin Dynamics
- Thyroid Cancer Diagnosis and Treatment
- Ear and Head Tumors
- Oral health in cancer treatment
- Dysphagia Assessment and Management
- Management of metastatic bone disease
Norfolk and Norwich University Hospital
2015-2024
Norfolk and Norwich University Hospitals NHS Foundation Trust
2014-2024
Royal College of Radiologists
2018-2024
Norfolk and Suffolk NHS Foundation Trust
2022-2024
The Honourable Society of Lincoln's Inn
2024
Norwich University
2023
Amsterdam University Medical Centers
2022
Clinical Trial Investigators
2021
Chelsea and Westminster Hospital NHS Foundation Trust
2020
European Society for Therapeutic Radiology and Oncology
2020
BackgroundThe incidence of human papillomavirus (HPV)-positive oropharyngeal cancer, a disease affecting younger patients, is rapidly increasing. Cetuximab, an epidermal growth factor receptor inhibitor, has been proposed for treatment de-escalation in this setting to reduce the toxicity standard cisplatin treatment, but no randomised evidence exists efficacy strategy.MethodsWe did open-label controlled phase 3 trial at 32 head and neck centres Ireland, Netherlands, UK, patients aged 18...
It is not known whether low-dose radioiodine (1.1 GBq [30 mCi]) as effective high-dose (3.7 [100 for treating patients with differentiated thyroid cancer or the effects of (especially at a low dose) are influenced by using either recombinant human thyrotropin (thyrotropin alfa) hormone withdrawal.At 29 centers in United Kingdom, we conducted randomized noninferiority trial comparing and radioiodine, each combination alfa withdrawal before ablation. Patients (age range, 16 to 80 years) had...
The indirect impact of the COVID-19 pandemic on cancer outcomes is increasing concern. However, extent to which key treatment modalities have been affected unclear. We aimed assess radiotherapy activity in England.In this population-based study, data relating all delivered for English NHS, between Feb 4, 2019, and June 28, 2020, were extracted from National Radiotherapy Dataset. Changes mean weekly courses, attendances (reflecting fractions), fractionation patterns following start UK...
Older and/or frail patients are underrepresented in landmark cancer trials. Tailored research is needed to address this evidence gap.
People with cancer are at increased risk of hospitalisation and death following infection SARS-CoV-2. Therefore, we aimed to conduct one the first evaluations vaccine effectiveness against breakthrough SARS-CoV-2 infections in patients a population level.
<h2>Summary</h2><h3>Background</h3> Most newly diagnosed oropharyngeal and hypopharyngeal cancers are treated with chemoradiotherapy curative intent but at the consequence of adverse effects on quality life. We aimed to investigate if dysphagia-optimised intensity-modulated radiotherapy (DO-IMRT) reduced radiation dose dysphagia aspiration related structures improved swallowing function compared standard IMRT. <h3>Methods</h3> DARS was a parallel-group, phase 3, multicentre, randomised,...
Persistent dysphagia following primary chemoradiation (CRT) for head and neck cancers can have a devastating impact on patients' quality of life. Single arm studies shown that the dosimetric sparing critical swallowing structures such as pharyngeal constrictor muscle supraglottic larynx translate to better functional outcomes. However, there are no current randomised confirm benefits swallow strategies. The aim Dysphagia/Aspiration at risk (DARS) trial is determine whether reducing dose...
Abstract This is the official guideline endorsed by specialty associations involved in care of head and neck cancer patients UK. A rational plan to manage necessary for all primaries. With emergence new level 1 evidence across several domains metastases, this will identify evidence-based recommendations management. Recommendations • Computed tomographic or magnetic resonance imaging mandatory staging disease, with choice modality dependant on used primary site, local availability expertise....
Large cohorts of patients with active cancers and COVID-19 infection are needed to provide evidence the association recent cancer treatment type mortality.
PurposePeople living with cancer and haematological malignancies are at an increased risk of hospitalisation death following infection acute respiratory syndrome coronavirus 2. Coronavirus third dose vaccine boosters proposed to boost waning immune responses in immunocompromised individuals increase protection; however, their effectiveness has not yet been systematically evaluated.MethodsThis study is a population-scale real-world evaluation the United Kingdom's booster programme for...
Five single nucleotide polymorphisms (SNPs) associated with thyroid cancer (TC) risk have been reported: rs2910164 (5q24); rs6983267 (8q24); rs965513 and rs1867277 (9q22); rs944289 (14q13). Most of these associations not replicated in independent populations the combined effects SNPs on examined. This study genotyped five TC 781 patients recruited through TCUKIN study. Genotype data from 6122 controls were obtained CORGI Wellcome Trust Case-Control Consortium studies. Significant detected...
Abstract Patients with cancer are at increased risk of hospitalisation and mortality following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, the SARS-CoV-2 phenotype evolution in patients since 2020 has not previously been described. We therefore evaluated on a UK populationscale from 01/11/2020-31/08/2022, assessing case-outcome rates hospital assessment(s), intensive care admission mortality. observed that disease become less non-cancer population....
Abstract Background Patients with intermediate and high-risk oropharyngeal cancer (OPC) have poorer response to standard treatment overall survival compared low-risk OPC. CompARE is designed test alternative approaches intensified for these patients improve survival. Methods a pragmatic phase III, open-label, multicenter randomised controlled trial an adaptive multi-arm, multi-stage design integrated QuinteT Recruitment Intervention. Eligible OPC include those human papillomavirus (HPV)...
A study of interobserver variation in the segmentation post-operative clinical target volume (CTV) and organs at risk (OARs) for parotid tumours was undertaken. The exercise performed as a baseline, repeated after 3 months using protocol to assess whether CTV conformity improved.Four head neck oncologists independently segmented CTVs OARs (contralateral parotid, spinal cord brain stem) on CT data sets five patients post parotidectomy. For each or OAR delineation, total calculated. level (CL)...
Importance Accurate identification of patient groups with the lowest level protection following COVID-19 vaccination is important to better target resources and interventions for most vulnerable populations. It not known whether SARS-CoV-2 antibody testing has clinical utility high-risk groups, such as people cancer. Objective To evaluate spike protein vaccine response (COV-S) associated risk breakthrough infection or hospitalization among patients Design, Setting, Participants This was a...