A5065419636- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer survivorship and care
- Radiomics and Machine Learning in Medical Imaging
- Thyroid Cancer Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Head and Neck Surgical Oncology
- Cleft Lip and Palate Research
- Colorectal and Anal Carcinomas
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Lung Cancer Diagnosis and Treatment
- Family Support in Illness
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Nausea and vomiting management
- Oral Health Pathology and Treatment
- Radiation Dose and Imaging
- Palliative Care and End-of-Life Issues
- Ovarian cancer diagnosis and treatment
- Molecular Biology Techniques and Applications
- Tracheal and airway disorders
- Childhood Cancer Survivors' Quality of Life
University of Birmingham
2018-2025
King's College London
2024
University Hospitals Birmingham NHS Foundation Trust
2024
BackgroundThe incidence of human papillomavirus (HPV)-positive oropharyngeal cancer, a disease affecting younger patients, is rapidly increasing. Cetuximab, an epidermal growth factor receptor inhibitor, has been proposed for treatment de-escalation in this setting to reduce the toxicity standard cisplatin treatment, but no randomised evidence exists efficacy strategy.MethodsWe did open-label controlled phase 3 trial at 32 head and neck centres Ireland, Netherlands, UK, patients aged 18...
Abstract Background Patients with intermediate and high-risk oropharyngeal cancer (OPC) have poorer response to standard treatment overall survival compared low-risk OPC. CompARE is designed test alternative approaches intensified for these patients improve survival. Methods a pragmatic phase III, open-label, multicenter randomised controlled trial an adaptive multi-arm, multi-stage design integrated QuinteT Recruitment Intervention. Eligible OPC include those human papillomavirus (HPV)...
Highlights•Oral rinse is the most common measure for estimating oral HPV prevalence.•We compared to pharyngeal wall and tongue base brushes, & tonsil tissue.•Combining all four sites, any HR-HPV prevalence were 18% 4.3%.•Oral misses 73% (11/15) of cases detected by other sites.•All 4 sample types combined improves detection over alone 38%.AbstractObjectivesHuman papillomavirus (HPV) mediated oropharyngeal cancer (OPC) incidence has increased dramatically. Accurate data are essential...
Abstract Background Approximately 40% of treated head and neck cancer (HNC) patients develop recurrence. The risk recurrence declines with time from treatment. Current guidelines recommend clinical follow-up every two months for the first years after treatment, reducing intensity over next three years. However, evidence effectiveness these regimes in detecting is lacking, calls more flexible, patient-centred strategies. Methods PETNECK2 a UK-based multi-centre programme examining new...
Background There is variable evidence and no randomized trials on the benefit of US elastography-guided fine-needle aspiration cytology (FNAC) over conventional US-guided FNAC alone for thyroid nodules. Purpose To compare efficacy versus in reducing nondiagnostic rates Materials Methods A pragmatic, multicenter controlled trial was performed at 18 secondary tertiary hospitals across England between February 2015 September 2018. Eligible adults with single or multiple nodules who had not...
Current follow-up for head and neck cancer (HNC) is ineffective, expensive fails to address patients' needs. The PETNECK2 trial will compare a new model of patient-initiated (PIFU) with routine scheduled follow-up. This article reports UK clinicians' views about HNC PIFU, inform the design.
BackgroundThe De-ESCALaTE HPV trial confirmed the dominance of cisplatin over cetuximab for tumour control in patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC). Here, we present analysis health-related quality life (HRQoL), resource use, and health care costs trial, as well complete 2-year survival recurrence.Materials methodsResource use HRQoL data were collected at intervals from baseline to 24 months post treatment (PT). Health estimated using...
Abstract Introduction ElaTION is a large multi-centre pragmatic randomised controlled trial, performed in 18 secondary/tertiary hospitals across England, comparing elastography ultrasound-guided fine needle aspiration cytology (EUS-FNAC) with FNAC (US-FNAC) alone the diagnostic assessment of thyroid nodules. Secondary trial outcomes, reported here, assessed accuracy ultrasound-alone (US) compared US-guided to inform and update current practice guidelines. Methods Adults single or multiple...
The objective of this work was to explore head and neck cancer (HNC) patients' their family members' views on acceptability feasibility patient-initiated follow-up (PIFU), including concerns anticipated benefits.Patients were recruited from UK HNC clinics, support groups advocacy groups. They completed a survey (n = 144) and/or qualitative interview 30), three with member. Qualitative data analysed thematically, quantitative using descriptive statistics.Preference for care in complex...
Current Head and Neck cancer (HNC) follow-up models are considered sub-optimal at detecting recurrences. We describe the development of a patient-initiated follow up (PIFU) trial intervention support package, to HNC patients engage in PIFU self-care behaviors.
109 Background: Trials in human papilloma virus associated oropharyngeal squamous cell carcinoma (HPVOPSCC), substituting cetuximab (CETUX) for cisplatin (CIS) with radiotherapy (RT), resulted decreased efficacy without improved toxicity or symptom burden. We reported that high intratumoral immune (ITIC) CD103 expression (> 30%), a marker of tissue-resident memory T cells, is better prognosis unselected patients HPVOPSCC treated CIS/RT. In this study our aim was to determine whether low...
Strain and shear wave elastography which is commonly used with concurrent real-time imaging known as ultrasound shear/strain a new diagnostic technique that has been reported to be useful in the diagnosis of nodules several organs. There conflicting evidence regarding its benefit over ultrasound-guided fine-needle aspiration cytology alone thyroid nodules.
6076 Background: The De-ESCALaTE trial confirmed the superiority of cisplatin over cetuximab in combination with radiotherapy for treatment low risk human papillomavirus positive oropharyngeal cancer (HPV+OPC). most common serious adverse events (SAEs) were due to vomiting and nausea, contrast oral mucositis concurrent cetuximab. In this study, we examined efficacy different hydration anti-emetic policies preventing cisplatin-related gastrointestinal renal toxicities as well related SAEs arm...