Laia Alemany
A5013748972- Head and Neck Cancer Studies
- RNA Research and Splicing
- Cervical Cancer and HPV Research
- Renal and related cancers
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Oral Health Pathology and Treatment
- RNA modifications and cancer
- Colorectal and Anal Carcinomas
- Esophageal Cancer Research and Treatment
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Circular RNAs in diseases
- Endometrial and Cervical Cancer Treatments
- Oral and Maxillofacial Pathology
- Influenza Virus Research Studies
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lymphadenopathy Diagnosis and Analysis
- Nutrition and Health in Aging
- Dysphagia Assessment and Management
Institut Català d'Oncologia
2016-2025
Institut d'Investigació Biomédica de Bellvitge
2016-2025
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2016-2025
Centro de Investigación Biomédica en Red
2018-2024
Instituto de Salud Carlos III
2017-2024
Institut Català d'Ornitologia
2024
Universitat de Barcelona
2024
Ajuntament de L’Hospitalet
2021
Duran i Reynals Hospital
2018-2020
Centro de Investigación Biomédica en Red de Cáncer
2018
We conducted a large international study to estimate fractions of head and neck cancers (HNCs) attributable human papillomavirus (HPV-AFs) using six HPV-related biomarkers viral detection, transcription, cellular transformation. Formalin-fixed, paraffin-embedded cancer tissues the oral cavity (OC), pharynx, larynx were collected from pathology archives in 29 countries. All samples subject histopathological evaluation, DNA quality control, HPV-DNA detection. Samples containing further HPV...
Importance In the US, oropharyngeal cancer, predominantly caused by high-risk (HR) human papillomavirus (HPV) infection, is most frequent HPV-associated surpassing cervical cancer. However, little known about oral HPV prevalence and genotype distribution in general population. Objective To assess factors associated with HR low-risk infection a US Design, Setting, Participants PROGRESS (Prevalence of Oral Infection, Global Assessment) was cross-sectional observational study conducted between...
Abstract There is limited understanding of epidemiology and time trends human papilloma virus (HPV)‐driven head neck cancers (HNC) in Japan, especially outside the oropharynx. To assess HPV‐driven HNC, a non‐interventional study (BROADEN) HNC patients diagnosed 2008–2009 2018–2019 was conducted Japan. Adult with oropharyngeal, nasopharyngeal, laryngeal, hypopharyngeal or oral cavity were included this study. HPV centrally tested using p16INK4a immunohistochemistry, HPV‐DNA PCR E6*I mRNA....
Literature on the role of human papillomavirus (HPV) in head and neck cancer (HNC) Italy is limited, especially for non-oropharyngeal tumours. Within context HPV-AHEAD study, we aimed to assess prognostic value different tests or test algorithms judging HPV carcinogenicity HNC factors related positivity at European Institute Oncology. We conducted a retrospective cohort study (2000–2010) total 696 primary patients. Formalin-fixed, paraffin-embedded tissues were studied. All HPV-DNA-positive...
Abstract Head and neck cancer is often diagnosed late prognosis for most head patients remains poor. To aid early detection, we developed a risk prediction model based on demographic lifestyle factors, human papillomavirus (HPV) serological markers genetic markers. A total of 10 126 cases 5254 controls from five North American European studies were included. HPV serostatus was determined by antibodies HPV16 oncoproteins (E6, E7) regulatory proteins (E1, E2, E4). The data split into training...
Abstract Objective: HPV-positive and HPV-negative head neck squamous cell carcinoma (HNSCC) are distinct entities from an epidemiological biological standpoint. We aimed to evaluate the predictive performance of polygenic risk scores (PRS), which could be a surrogate when behavioral data missing or deemed unreliable, for tobacco smoking (Smoking Initiation [SI], Age Smoking Initiation, Cigarettes Per Day [CPD], Cessation) alcohol consumption (Drinks Week [DPW]) their impact on HNSCC...
Abstract Background The incidence of high-risk human papillomavirus (hrHPV)-driven head and neck squamous cell carcinoma, in particular oropharyngeal cancers (OPC), is increasing high-resource countries. Patients with HPV-induced cancer respond better to treatment consequently have lower case-fatality rates than patients HPV-unrelated OPC. These considerations highlight the importance reliable accurate markers diagnose truly Methods accuracy three possible test strategies, i.e. (a) hrHPV DNA...
Background Human papillomavirus (HPV) is the cause of a fraction head and neck squamous cell carcinoma. Although this relation well-known, it still not clear role HPV in premalignant oral lesions such as lichen planus (OLP) dysplasia. We aimed to evaluate HPV-DNA prevalence type distribution set biopsies obtained from patients diagnosed with OLP dysplasia, well these lesions. Methods A retrospective cohort all consecutively March 30th 1995 May 21st 2014 at Hospital Bellvitge Odontological...
The incidence of human papillomavirus (HPV)-related oropharyngeal cancer is increasing in some regions. Nevertheless, the epidemiology this disease has not been extensively investigated southern Europe. We conducted a retrospective cohort study patients diagnosed with primary from 1991 to 2016. Cancer tissues underwent histopathological evaluation, DNA quality control, HPV-DNA detection and p16INK4a immunohistochemistry. Data were collected medical records. Factors associated HPV positivity...
Background: Anti-epithermal-growth-factor-receptor (EGFR) therapies in combination with radiotherapy are being studied on de-escalation clinical trials for HPV-related oropharyngeal cancer (OPC) patients. The HPV16-E5 oncoprotein increases recycling of activated EGFR to the cell surface, enhancing factor signal transduction. Our aim was evaluate viral oncogene expression as well and phosphorylated-EGFR (pEGFR), protein levels biomarkers outcome a retrospective cohort OPC Methods:...
Background: Tests or test algorithms for diagnosing HPV-driven oral cavity and laryngeal head neck carcinomas (HNC) have not been yet validated, the differences among sites comprehensively evaluated. We aimed to assess utility of a diagnostic algorithm detection (OCC), oropharyngeal (OPC) (LC) using HPV-DNA testing followed by p16INK4a immunohistochemistry, taking E6*I mRNA as reference standard. Methods: Formalin-fixed paraffin-embedded OCC, OPC, LC were collected from pathology archives in...