A5015984938- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Virus-based gene therapy research
- Medical Imaging Techniques and Applications
- Dysphagia Assessment and Management
- Head and Neck Surgical Oncology
- Oral health in cancer treatment
- Cancer Diagnosis and Treatment
- Cancer Research and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- MRI in cancer diagnosis
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Voice and Speech Disorders
- Management of metastatic bone disease
- Cerebrovascular and Carotid Artery Diseases
- Radiation Therapy and Dosimetry
- Brain Metastases and Treatment
- Cardiovascular Health and Disease Prevention
- CRISPR and Genetic Engineering
Institute of Cancer Research
2013-2024
Royal Marsden NHS Foundation Trust
2015-2024
Royal Marsden Hospital
2013-2023
The University of Texas MD Anderson Cancer Center
2023
University of Warwick
2018
Royal Brompton Hospital
2014
University of Pennsylvania
2012
Institute of Cancer Research
2011-2012
Cancer Research UK
2012
National Health Service
2008-2011
Xerostomia is the most common late side-effect of radiotherapy to head and neck. Compared with conventional radiotherapy, intensity-modulated (IMRT) can reduce irradiation parotid glands. We assessed hypothesis that parotid-sparing IMRT reduces incidence severe xerostomia.We undertook a randomised controlled trial between Jan 21, 2003, Dec 7, 2007, compared (control) IMRT. randomly assigned patients histologically confirmed pharyngeal squamous-cell carcinoma (T1-4, N0-3, M0) at six UK...
BackgroundThe incidence of human papillomavirus (HPV)-positive oropharyngeal cancer, a disease affecting younger patients, is rapidly increasing. Cetuximab, an epidermal growth factor receptor inhibitor, has been proposed for treatment de-escalation in this setting to reduce the toxicity standard cisplatin treatment, but no randomised evidence exists efficacy strategy.MethodsWe did open-label controlled phase 3 trial at 32 head and neck centres Ireland, Netherlands, UK, patients aged 18...
It is not known whether low-dose radioiodine (1.1 GBq [30 mCi]) as effective high-dose (3.7 [100 for treating patients with differentiated thyroid cancer or the effects of (especially at a low dose) are influenced by using either recombinant human thyrotropin (thyrotropin alfa) hormone withdrawal.At 29 centers in United Kingdom, we conducted randomized noninferiority trial comparing and radioiodine, each combination alfa withdrawal before ablation. Patients (age range, 16 to 80 years) had...
The role of image-guided surveillance as compared with planned neck dissection in the treatment patients squamous-cell carcinoma head and who have advanced nodal disease (stage N2 or N3) received chemoradiotherapy for primary is a matter debate.
Abstract Purpose: To conduct a phase I clinical trial with second-generation oncolytic herpes simplex virus (HSV) expressing granulocyte macrophage colony-stimulating factor (Onco VEXGM-CSF) to determine the safety profile of virus, look for evidence biological activity, and identify dosing schedule later studies. Experimental Design: The was administered by intratumoral injection in patients cutaneous or s.c. deposits breast, head neck gastrointestinal cancers, malignant melanoma who had...
Abstract A rising incidence of oropharyngeal squamous cell carcinoma (OPSCC) has occurred throughout the developed world, where it been attributed to an increasing impact human papillomavirus (HPV) on disease etiology. This report presents findings a multicenter cross-sectional retrospective study aimed at determining proportion HPV-positive and HPV-negative OPSCC within United Kingdom. Archival tumor tissue blocks from 1,602 patients previously diagnosed with (2002–2011) were collated 11...
<h2>Summary</h2><h3>Background</h3> Most newly diagnosed oropharyngeal and hypopharyngeal cancers are treated with chemoradiotherapy curative intent but at the consequence of adverse effects on quality life. We aimed to investigate if dysphagia-optimised intensity-modulated radiotherapy (DO-IMRT) reduced radiation dose dysphagia aspiration related structures improved swallowing function compared standard IMRT. <h3>Methods</h3> DARS was a parallel-group, phase 3, multicentre, randomised,...
Abstract Purpose: This study sought to define the recommended dose of JS1/34.5-/47-/GM-CSF, an oncolytic herpes simplex type-1 virus (HSV-1) encoding human granulocyte-macrophage colony-stimulating factor (GM-CSF), for future studies in combination with chemoradiotherapy patients squamous cell cancer head and neck (SCCHN). Experimental Design: Patients stage III/IVA/IVB SCCHN received (70 Gy/35 fractions concomitant cisplatin 100 mg/m2 on days 1, 22, 43) dose-escalating (106, 106, 106 pfu/mL...
Radical radiotherapy is a standard form of management localised prostate cancer. Conformal treatment planning spares adjacent normal tissues reducing treatment-related side effects and may permit safe dose escalation. We have tested the on tumour control escalating investigated appropriate target volume margin. After an initial 3-6 month period androgen suppression, 126 men were randomised treated with using 2 by factorial trial design. The included base seminal vesicles (SV) or complete SV...
Aim To evaluate the tolerability and efficacy of sorafenib in patients with thyroid carcinoma. Methods Patients progressive locally advanced/metastatic medullary carcinoma (MTC), or differentiated (DTC) non-radioiodine-avid disease, were treated 400 mg twice daily until disease progression. The primary endpoint was radiological response rate (RR) at 6 months. Secondary endpoints RR 3, 9 12 months, biochemical responses, toxicity, biomarker analyses progression free overall survival (OS)....
Following chemo-radiotherapy (CCRT) for human papilloma virus positive (HPV+) locally advanced head and neck cancer, patients frequently undergo unnecessary dissection (ND) and/or repeated biopsies abnormal PET-CT, which causes significant morbidity. We assessed the role of circulating HPV DNA in identifying 'true' residual disease.We prospectively recruited test (n=55) validation (n=33) cohorts. status was confirmed by E7 RT-PCR. developed a novel amplicon-based next generation sequencing...
Persistent dysphagia following primary chemoradiation (CRT) for head and neck cancers can have a devastating impact on patients' quality of life. Single arm studies shown that the dosimetric sparing critical swallowing structures such as pharyngeal constrictor muscle supraglottic larynx translate to better functional outcomes. However, there are no current randomised confirm benefits swallow strategies. The aim Dysphagia/Aspiration at risk (DARS) trial is determine whether reducing dose...
AZD6738 is an orally active ATR inhibitor (ATRi) currently in phase I clinical trials. We found vitro growth inhibitory activity of this ATRi a panel human cancer cell lines. demonstrated radiosensitization by to single radiation fractions multiple lines independent both p53 and BRCA2 status the clonogenic assay. Radiosensitization clinically relevant doses fractionated was using 3D tumor spheroid model and, vivo, radiosensitized abrogating radiation-induced G
Background and purposeSevere acute mucositis commonly results from head neck (chemo)radiotherapy. A predictive model of could guide clinical decision-making inform treatment planning. We aimed to generate such a using spatial dose metrics machine learning.Materials methodsPredictive models severe were generated radiotherapy (dose–volume metrics) data. Penalised logistic regression, support vector classification random forest (RFC) compared. Internal validation was performed (with...
Duligotuzumab, a novel dual-action humanized IgG1 antibody that blocks ligand binding to epidermal growth factor receptor (EGFR) and human 3 (HER3), inhibits signaling from all ligand-dependent HER dimers, can elicit antibody-dependent cell-mediated cytotoxicity. High tumor-expression of neuregulin 1 (NRG1), HER3, may enhance sensitivity duligotuzumab.This multicenter, open-label, randomized phase II study (MEHGAN) evaluated drug efficacy in patients with recurrent/metastatic (R/M) squamous...
Anaplastic thyroid cancer (ATC), an aggressive malignancy, is associated with a poor prognosis and unmet need for effective treatment, especially patients without BRAF mutations or NTRK RET fusions. Lenvatinib US Food Drug Administration-approved radioiodine-refractory differentiated has previously demonstrated activity in small study of ATC (n = 17). We aimed to further evaluate lenvatinib ATC.This open-label, multicenter, international, phase II enrolled ATC, who had ≥ 1 measurable target...
Object. This study was undertaken to assess the long-term efficacy and toxicity of conventional fractionated external-beam radiation in treatment benign skull base meningioma. Methods. is a retrospective 82 patients with histologically verified meningioma treated by surgery followed at Royal Marsden Hospital between 1962 1992. The 5- 10-year progression-free survival (PFS) rates were 92% 83%, respectively, site disease being only independent prognostic factor for tumor control according...