A5034212659- Cervical Cancer and HPV Research
- Head and Neck Cancer Studies
- Genital Health and Disease
- Cancer Diagnosis and Treatment
- Reproductive tract infections research
- Endometrial and Cervical Cancer Treatments
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Head and Neck Surgical Oncology
- Esophageal Cancer Research and Treatment
- Molecular Biology Techniques and Applications
- Urological Disorders and Treatments
- DNA Repair Mechanisms
- Urologic and reproductive health conditions
- Microbial infections and disease research
- Thyroid Cancer Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Hepatitis B Virus Studies
- Cancer Immunotherapy and Biomarkers
- Cleft Lip and Palate Research
- RNA modifications and cancer
- Colorectal and Anal Carcinomas
- T-cell and Retrovirus Studies
- Listeria monocytogenes in Food Safety
- NF-κB Signaling Pathways
Cardiff University
2012-2023
Tenovus Cancer Care
2015-2018
University of Wales Institute Cardiff
2015
In-Q-Tel
2010
University of Wales
2004-2007
Swansea University
2004-2005
University Hospital of Wales
1983
The role of image-guided surveillance as compared with planned neck dissection in the treatment patients squamous-cell carcinoma head and who have advanced nodal disease (stage N2 or N3) received chemoradiotherapy for primary is a matter debate.
Human papillomavirus-positive oropharyngeal squamous cell carcinoma is increasing in incidence worldwide. Current treatments are associated with high survival rates but often result significant long-term toxicities. In particular, dysphagia has a negative impact on patient quality of life and health. The aim PATHOS to determine whether reducing the intensity adjuvant treatment after minimally invasive transoral surgery this favourable prognosis disease will better swallowing function whilst...
Knowledge of differences in human papillomavirus (HPV)-type prevalence between high-grade cervical intraepithelial neoplasia (HG-CIN) and invasive cancer (ICC) is crucial for understanding the natural history HPV-infected lesions potential impact HPV vaccination on prevention. More than 6,000 women diagnosed with HG-CIN or ICC from 17 European countries were enrolled two parallel cross-sectional studies (108288/108290). Centralised histopathology review standardised HPV-DNA typing applied to...
Abstract A rising incidence of oropharyngeal squamous cell carcinoma (OPSCC) has occurred throughout the developed world, where it been attributed to an increasing impact human papillomavirus (HPV) on disease etiology. This report presents findings a multicenter cross-sectional retrospective study aimed at determining proportion HPV-positive and HPV-negative OPSCC within United Kingdom. Archival tumor tissue blocks from 1,602 patients previously diagnosed with (2002–2011) were collated 11...
Cervical glandular neoplasias (CGN) present a challenge for cervical cancer prevention due to their complex histopathology and difficulties in detecting preinvasive stages with current screening practices. Reports of human papillomavirus (HPV) prevalence type-distribution CGN vary, providing uncertain evidence support prophylactic vaccination HPV screening. This study [108288/108290] assessed women diagnosed adenocarcinoma situ (AIS, N = 49), adenosquamous carcinoma (ASC, 104), various...
BackgroundVulval intraepithelial neoplasia is a skin disorder affecting the vulva that, if left untreated, can become cancerous. Currently, standard treatment for patients with vulval surgery, but this approach does not guarantee cure and be disfiguring, causing physical psychological problems, particularly in women of reproductive age. We aimed to assess activity, safety, feasibility two topical treatments—cidofovir imiquimod—as an alternative surgery female neoplasia.MethodsWe recruited...
The incidence of Human Papillomavirus (HPV) associated oropharyngeal cancer (OPC) is increasing. HPV-associated OPC appear to have better prognosis than HPV-negative OPC. aim this study was robustly determine the prevalence HPV-positive in an unselected UK population and correlate HPV positivity with clinical outcome.HPV testing by GP5+/6+ PCR, In Situ Hybridisation (ISH) p16 immunohistochemistry (IHC) performed on 138 OPCs diagnosed South Wales (UK) between 2001-06. Kaplan-Meier analysis...
The introduction of OpenAI's ChatGPT has widely been considered a turning point for assessment in higher education. Whilst we find ourselves on the precipice profoundly disruptive technology, generative artificial intelligence (AI) is here to stay. At present, institutions around world are considering how best respond such new and emerging tools, ranging from outright bans re-evaluating strategies. In evaluating extent problem that these tools pose marking assessments, study was designed...
DNA methylation changes in human papillomavirus type 16 (HPV16) are common and might be important for identifying women at increased risk of cervical cancer. Using recently published data from Costa Rica we developed a classification score to differentiate with intraepithelial neoplasia grade 2 or 3 (CIN2/3) those no evident high‐grade lesions. Here, aim investigate the performance using UK. Exfoliated cells baseline 6‐months follow‐up were analyzed 84 selected randomized clinical trial...
Abstract Background There are variations in the proportions of head and neck cancers caused by human papillomavirus (HPV) between countries regions. It is unclear if these true or due to different study designs assays. Methods We tested formalin‐fixed paraffin‐embedded diagnostic biopsies for p16 immunohistochemistry HPV‐DNA (by polymerase chain reaction [PCR] situ hybridization [ISH]) using validated protocols on samples from 801 patients with cancer recruited prospectively 2006 2011 4...
Abstract In this study, the frequency of BRAF mutation was investigated in a series 67 cases papillary thyroid cancer (PTC) patients from Ukraine. Thirty‐two were aged 30 years or older at time diagnosis and 35 under 16. Tumour microdissected paraffin wax‐embedded sections, DNA extracted, presence T1796A demonstrated by two different methods: PCR followed restriction enzyme digestion primer extension assay detection using MALDI‐TOF mass spectrometry. Eighteen (58%) adult cases, but only one...
The incidence of human papillomavirus (HPV)-associated tonsil cancer is increasing but the prevalence HPV, and premalignant precursors, in tissue unknown. We aimed to assess HPV infection nonmalignant tonsillar crypt epithelia histopathologically characterise positive samples. Formalin-fixed paraffin-embedded (FFPE) specimens were obtained from an age- sex-stratified random sample patients aged 0-69 years whose paired tonsils archived following elective tonsillectomy at hospitals throughout...
Aims To establish the human papillomavirus (HPV) type-specific prevalence in cervical cancer and high-grade lesions UK prior to introduction of national HPV vaccination. Methods Specimens (n=1235) intraepithelial neoplasia (CIN)3 (n=2268) were tested for genotypes England, Scotland, Wales Northern Ireland. Data pooled weighted estimates presented. Results Among cases, 95.8% positive at least one high-risk (HR) type. Restricting those with HR HPV, proportion HPV16 and/or HPV18 was similar...
The objective of this study was to describe human papillomavirus (HPV) prevalence in South Wales relation age, cytology and social deprivation. This an unlinked, prospective, anonymous, population-based study. DNA purified from 1911 liquid-based samples (mean age 37.7 years, 93.2% negative, deprivation average score 17.9) using quality assured techniques the presence virus determined by PCR-Enzyme Immuno Assay (PCR-EIA). 209 (10.9%) contained high-risk (HR) HPV infection which 36.4% had...
In this cross-sectional population-based study we determine human papillomavirus (HPV) prevalence in South Wales to provide comprehensive baseline data for future assessment of the impact prophylactic HPV vaccination and help inform screening strategies. Liquid-based cytology samples from women attending routine cervical were collected (n=10 000: mean age 38 years, 93% negative, 64.8% 50% least deprived LSOA according social deprivation score (SDS)). High-Risk (HR) Low-Risk was performed...