A5041095922- Head and Neck Cancer Studies
- COVID-19 and healthcare impacts
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Economic and Financial Impacts of Cancer
- Lung Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Head and Neck Surgical Oncology
- Oral health in cancer treatment
- Radiopharmaceutical Chemistry and Applications
- Healthcare cost, quality, practices
- Salivary Gland Tumors Diagnosis and Treatment
- Radiation Dose and Imaging
- Cancer Immunotherapy and Biomarkers
- Tracheal and airway disorders
- Esophageal Cancer Research and Treatment
- Dysphagia Assessment and Management
- Esophageal and GI Pathology
- Mobile Health and mHealth Applications
- Management of metastatic bone disease
- Effects of Radiation Exposure
- Bone and Joint Diseases
- Thyroid Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- Multiple and Secondary Primary Cancers
Guy's and St Thomas' NHS Foundation Trust
2016-2025
King's College London
2024-2025
Institute of Cancer Research
2023
Guy's Hospital
2021-2022
King's College Hospital NHS Foundation Trust
2021
St Thomas' Hospital
2013-2021
Cancer Clinic
2020
St. Thomas Hospital
2020
Saint Thomas West Hospital
2020
Saint Thomas Hospital
2020
<h2>Summary</h2><h3>Background</h3> Most newly diagnosed oropharyngeal and hypopharyngeal cancers are treated with chemoradiotherapy curative intent but at the consequence of adverse effects on quality life. We aimed to investigate if dysphagia-optimised intensity-modulated radiotherapy (DO-IMRT) reduced radiation dose dysphagia aspiration related structures improved swallowing function compared standard IMRT. <h3>Methods</h3> DARS was a parallel-group, phase 3, multicentre, randomised,...
<bold>Background:</bold> There is insufficient evidence to support clinical decision-making for cancer patients diagnosed with COVID-19 due the lack of large studies. <bold>Methods:</bold> We used data from a single UK Cancer Center assess demographic/clinical characteristics 156 confirmed diagnosis between 29 February and 12 May 2020. Logistic/Cox proportional hazards models were identify which demographic and/or associated severity/death. <bold>Results:</bold> 128 (82%) presented...
Abstract Background Using an updated dataset with more patients and extended follow-up, we further established cancer patient characteristics associated COVID-19 death. Methods Data on all a positive reverse transcription-polymerase chain reaction swab for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) at Guy’s Cancer Centre King’s College Hospital between 29 February 31 July 2020 was used. Cox proportional hazards regression performed to identify which factors were mortality....
Abstract This is the official guideline endorsed by specialty associations involved in care of head and neck cancer patients UK. Although much commoner eastern hemisphere, with an age-standardised incidence rate 0.39 per 100 000 population, cancers nasopharynx form one rarer subsites neck. 1 paper provides recommendations on work up management nasopharyngeal based existing evidence base for this condition. Recommendations • Patients carcinoma (NPC) should be assessed rigid fibre-optic...
Objectives To analyse survival and toxicity outcomes in patients treated with primary intensity‐modulated radiotherapy ( IMRT ) for oropharyngeal squamous cell carcinoma OPSCC the era of routine human papilloma virus HPV testing. Design Single‐institution case series. Setting Tertiary Head Neck Cancer Unit. Participants A total 186 received (+/− chemotherapy) radical treatment between March 2010 December 2013. status was available 88% cases. Median radiation dose 65 Gy 30 daily fractions....
Background and Purpose: The performance generalisability of machine learning (ML) models relies on high-quality data. Retrospective prospective collection data for research use whilst respecting protection patient privacy remains a challenge in the clinical environment. Currently, months laborious extraction annotation are often necessary before analysis can begin. We present novel institutional federated lake, utilising open-source software, to facilitate efficient production ML from Head...
Background: Real-world data (RWD) is essential in head and neck cancer (HNC) research, offering insights into outcomes among diverse, comorbid patients often underrepresented clinical trials. Methods: We developed RT-HaND-C, a multi-source dataset integrating structured EHR data, unstructured extracted using an AI-driven NLP tool, previously manually-curated datasets, with extensive demographic, disease, laboratory, treatment, outcome radiotherapy dosimetry for all HNC oncology seen at our...
12121 Background: Radiation-induced oral mucositis (RIOM) affects up to 80% of people undergoing treatment for head and neck cancer (HNC), reaching nearly 100% in altered or accelerated fractional radiation. Current approaches necessitate multiple supportive care pharmacotherapies with no approved preventative pharmaceutical products available the reduction RIOM patients HNC. To address this unmet medical need an innovative topical vasoconstrictor solution (NG11-2) has been developed a...
Abstract Objective/Hypothesis: To assess the oncologic efficacy and functional outcome of selective postchemoradiotherapy neck dissection for stage IV head squamous cell carcinoma. Methods: Retrospective review patients with N 2–3 cervical metastases at presentation who underwent planned after complete biopsy‐proven clearance primary site mucosal disease chemoradiotherapy between 2000 2006. Results: There were 31 males 10 females. The average age was 57 ± 9 years. oropharynx most common (n =...
Clinical evaluation of tumour‐infiltrating lymphocytes as a prognostic factor in patients with human papillomavirus‐associated oropharyngeal squamous cell carcinoma Aims The majority papillomavirus (HPV)‐associated (OpSCC) have favourable survival outcomes, but significant minority individuals will die their disease. There are currently no definitive criteria which to identify HPV‐associated OpSCC poor outcomes. Recent reports suggest that quantitative T‐cell subpopulations may be value, the...
Nivolumab is an anti-PD-1 monoclonal antibody currently used as immunotherapy for patients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) evidence of disease progression after platinum-based chemotherapy. This study evaluates real-world safety treatment outcomes non-trial nivolumab use. A retrospective multicenter cohort HNSCC treated between January 2017 March 2020 was performed. Overall, 123 were included. The median age 64 years, the majority male (80.5%) had a...
To investigate if cone beam CT (CBCT) can be used to estimate the delivered dose in head and neck intensity-modulated radiotherapy (IMRT).15 patients (10 without replan 5 with replan) were identified retrospectively. Weekly CBCT was co-registered original planning CT. Original high-dose clinical target volume (CTV1), low-dose CTV (CTV2), brainstem, spinal cord, parotids external body contours copied each modified account for anatomical changes. Corresponding volumes (PTVs) organ-at-risk...
Objectives: To analyze survival outcomes in patients with oropharygeal cancer treated primary intensity modulated radiotherapy (IMRT) using decision tree algorithms. Methods: A total of 273 newly diagnosed oropharyngeal were identified between March 2010 and December 2016. The data set contained nine predictor variables a dependent variable (overall (OS) status). open-source R software was used. Survival estimated by Kaplan–Meier method. Important explanatory selected the random forest...