A5009426436- COVID-19 and healthcare impacts
- Economic and Financial Impacts of Cancer
- Global Cancer Incidence and Screening
- Healthcare cost, quality, practices
- COVID-19 Clinical Research Studies
- Cancer, Lipids, and Metabolism
- Body Contouring and Surgery
- Lymphatic System and Diseases
- Diagnosis and Treatment of Venous Diseases
- Abdominal Trauma and Injuries
- Occupational and environmental lung diseases
- Metabolism, Diabetes, and Cancer
- Cancer survivorship and care
- Epigenetics and DNA Methylation
- Systemic Sclerosis and Related Diseases
- Methemoglobinemia and Tumor Lysis Syndrome
- Health, Environment, Cognitive Aging
- Advances in Oncology and Radiotherapy
- Prostate Cancer Treatment and Research
- Cancer Risks and Factors
- Nonmelanoma Skin Cancer Studies
- Vaccine Coverage and Hesitancy
- Chronic Disease Management Strategies
- Healthcare Systems and Challenges
- Lung Cancer Diagnosis and Treatment
King's College London
2020-2025
Memorial Sloan Kettering Cancer Center
2025
London Cancer
2022-2023
Abstract Background Using an updated dataset with more patients and extended follow-up, we further established cancer patient characteristics associated COVID-19 death. Methods Data on all a positive reverse transcription-polymerase chain reaction swab for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) at Guy’s Cancer Centre King’s College Hospital between 29 February 31 July 2020 was used. Cox proportional hazards regression performed to identify which factors were mortality....
Emergency approval of vaccines against COVID-19 provides an opportunity for us to return pre-pandemic oncology care. However, safety data in cancer patients is lacking due their exclusion from most phase III trials. We included all aged less than 65 years who received a vaccine 8 December 2020 28 February 2021 at our London tertiary centre. Solicited and unsolicited vaccine-related adverse events (VRAEs) were collected using telephone or face-to-face consultation. Within the study period,...
The invasion of Ukraine by Russia in February 2022 has resulted destruction healthcare infrastructure and triggered the largest wave internally displaced populations refugees since World War Two. Conflicts transitioned countries such as create new non-communicable disease (NCD) challenges, especially for cancer care humanitarian assistance host countries. In early days, rapid attempts were made to model possible impacts.By evaluating open source intelligence used first three months conflict...
We investigated the association between metabolic syndrome (MetS) and its components risk of prostate cancer (PCa) in a cohort men enrolled UK Biobank. Our study included 220 622 PCa-free with baseline measurements triglycerides (TGs), HDL-cholesterol (HDL), glycated hemoglobin (HbA1c), blood pressure (BP), waist circumference (WC). Multivariable Cox proportional hazards regression was used to analyze associations PCa for: individual (TG, HDL, HbA1c, BP, WC), combinations two three...
The SARS-CoV-2 (COVID-19) pandemic is having a large effect on the management of cancer patients. This study reports approach and outcomes patients receiving radical surgery with curative intent between March September 2020 (in comparison to 2019) in European Institute Oncology, IRCCS (IEO) Milan South East London Cancer Alliance (SELCA). Both institutions implemented COVID-19 minimal pathway where were required self-isolate prior admission swabbed for within 72 h surgery. Positive had...
547 Background: ASCO guidelines state that most cytotoxic drugs should be dosed according to full body surface area (BSA) without limiting the dose on basis of obesity. This approach is supported by a lack evidence suggest patients with obesity, when fully-dosed, experience higher risk toxicity. Indeed, historical suggests obese, fully-dosed may lower neutropenia than normal weight patients. However, questions remain regarding representativeness trial data which this based. We examined issue...
Bilirubin has strong antioxidant properties that have been hypothesized to be preventive against the development of cancer. Thus, we aimed investigate association between serum total bilirubin (STB) and risk overall site-specific cancers in large Swedish Apolipoprotein Mortality Risk (AMORIS) cohort. We also performed a systematic review meta-analysis for specific cancer types (colorectal, breast lung). found no high levels STB Regarding cancer, there was an inverse increased lung (Hazard...
Very few studies investigating COVID-19 in cancer patients have included as controls. We aimed to identify factors associated with the risk of testing positive for SARS CoV2 infection a cohort patients. analyzed data from all swabbed between 1st March and 31st July 2020 at Guy’s Cancer Centre. conducted logistic regression analyses which were test. Results: Of 2152 tested COVID-19, 190 (9%) positive. Male sex, black ethnicity, hematological type positively (OR = 1.85, 95%CI:1.37–2.51; OR...
Background: Few studies have investigated the long-term effects of COVID-19 on cancer patients. Materials & methods: The authors conducted a telephone survey symptoms patients from Guy's Cancer Centre. They compared whose occurred/got worse over 4 weeks after diagnosis (classified as long COVID) with who did not develop or in first diagnosis. Results: analyzed responses 80 previous diagnosis; 51.3% (n = 41) developed COVID. most common were fatigue, breathlessness and cognitive impairment....
To analyse the effectiveness of rapid diagnostic clinics (RDCs) as an alternative pathway for patients with concerning symptoms and a faecal immunochemical test (FIT) result <10. Our primary endpoint was rate colorectal cancer (CRC) detection. Second endpoints were rates other cancers gastrointestinal (GI) serious benign conditions. Finally, we analysed specific followed by FIT <10 at Guy's St Thomas NHS Foundation Trust (GSTT) RDC. A retrospective prospective cohort study. GSTT RDC, one...
Abstract Objective To report on the outcomes of urological cancer patients undergoing radical surgery between March–September 2020 (compared with 2019) in European Institute Oncology (IEO) Milan and South East London Cancer Alliance (SELCA). Materials Methods Since March 2020, both institutions implemented a COVID‐19 minimal ‘green’ pathway, whereby were required to isolate for 14 days prior admission negative polymerase chain reaction (PCR) test within 3 surgery. positive had deferred until...
During the COVID pandemic, there was a paucity of data to support clinical decision-making for anticancer treatments. We evaluated safety radical treatments which were delivered whilst mitigating risks concurrent COVID-19 infection.Using descriptive statistics, we report on characteristics and short-term outcomes patients undergoing cancer treatment during first wave compared similar pre-pandemic period.Compared 2019, number in 2020 reduced by: 28% surgery; 18% SACT; 10% RT. Within SACT, 36%...
Abstract Background The COVID-19 pandemic has had an enormous impact on the experiences of patients across all health disciplines, especially those cancer patients. study aimed to understand who underwent surgery during first two waves at Guy’s Cancer Centre, which is a large tertiary centre in London. Methods A mixed-methods approach was adopted for this study. Firstly, survey co-designed by research team and patient group. Patients were invited take part survey. Results analysed...
Background Rapid diagnostic clinics (RDCs) provide a streamlined holistic pathway for patients presenting with non-site specific (NSS) symptoms concerning of malignancy. The current study aimed to: 1) assess the prevalence anxiety and depression, 2) identify combination patient characteristics associated severe depression at Guy’s St Thomas’ Foundation Trust (GSTT) RDC in Southeast London. Additionally, we compared standard statistical methods machine learning algorithms predicting...
Abstract Background Safe provision of systemic anti-cancer treatment (SACT) during the COVID-19 pandemic remains an ongoing concern amongst clinicians. Methods Retrospective analysis on uro-oncology patients who continued or started SACT between 1st March and 31st May 2020 (with 2019 as a comparator). Results 441 received in (292 prostate, 101 renal, 38 urothelial, 10 testicular) compared to 518 (340 121 42 15 testicular). In 2020, there were 75.00% fewer with stage 3 cancers receiving ( p...
Aim: To evaluate the impact of pandemic on well-being cancer staff and determine uptake opt-in mitigation strategies. Materials & methods: Staff at Guy's Cancer Centre (London, UK) participated in an anonymized survey between May August 2021. Results: Of 1182 staff, 257 (21.7%) participated. Ethnicity (p = 0.020) comorbidity burden 0.022) were associated with SARS-CoV-2 infection status. 199 respondents, seven (3.6%) vaccine-hesitant, which was low flu vaccine < 0.001). Greater stress...