A5054272255- Head and Neck Cancer Studies
- Cervical Cancer and HPV Research
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Cancer-related molecular mechanisms research
- Ear and Head Tumors
- Esophageal Cancer Research and Treatment
- Cancer Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Lung Cancer Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Cancer, Lipids, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Mechanical stress and fatigue analysis
- Immune Response and Inflammation
- Respiratory viral infections research
- Metallurgy and Material Forming
- Tumors and Oncological Cases
- Cancer-related Molecular Pathways
- Otolaryngology and Infectious Diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Bone Tumor Diagnosis and Treatments
- Cancer Immunotherapy and Biomarkers
Copenhagen University Hospital
2022-2025
University of Copenhagen
2018-2025
Rigshospitalet
2018-2025
University of Malaya
2011
Denmark, alongside other Scandinavian countries, the United States, Canada, and Kingdom, has high prevalence of human papillomavirus (HPV). Our oropharyngeal squamous cell carcinoma (OPSCC) database includes all diagnosed cases in Eastern Denmark during a period more than two decades. We investigated incidence, survival, recurrence patients with OPSCC combined p16- HPV testing covering consecutive 21-year period. Age-adjusted incidence rate (AAIR) per 100,000, survival models, Cox...
A parapharyngeal abscess (PPA) was diagnosed and aspirated under local anesthesia using transoral ultrasound by an ENT surgeon. This case demonstrates that is a valuable point‐of‐care tool for both diagnosing PPA enabling minimally invasive, ultrasound‐guided drainage. Laryngoscope , 2025
ABSTRACT Background Oropharyngeal squamous cell carcinoma (SCC) can present as cancer of unknown primary, where only cervical lymph node metastases are identified. Most tumors, particularly human‐papillomavirus‐associated ones, located in the palatine/lingual tonsils. When this is not case, additional imaging with 2‐deoxy‐2‐[ 18 F]fluoro‐D‐glucose positron emission tomography ([ F]FDG‐PET) and ultrasound be helpful. Methods A 68‐year‐old male bilateral metastasis from an HPV‐positive SCC, no...
The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has increased in the past decades due to carcinogenic HPV infection. As this patient group suffers from considerable mortality and treatment morbidity it is important improve prognostic strategies OPSCC. Inflammation plays a key role cancer neutrophil-to-lymphocyte ratio (NLR) blood been suggested as factor for This study aimed investigate impact NLR on overall survival (OS) recurrence-free (RFS) retrospective cohort 1370...
BackgroundUncertainty persists regarding clinical and treatment variations crucial to consider when comparing high human papillomavirus (HPV)-prevalence oropharyngeal squamous cell carcinoma (OPSCC) cohorts for accurate patient stratification replicability of trials across different geographical areas.MethodsOPSCC patients were included from The University Texas MD Anderson Cancer Center (UTMDACC), USA Hospital Copenhagen, Denmark 2015–2020, (n = 2484). Outcomes 3-year overall survival (OS)...
The increases observed in incidence and survival of oropharyngeal squamous cell carcinoma (OPSCC) have been attributed to human papillomavirus (HPV) infection, but the survival-impact specific genotypes is poorly understood. We investigated potential influence HPV on HPV-positive (HPV+) OPSCC. All patients with HPV+/p16+ OPSCC available genotype data within period 2011 2017 Eastern Denmark were included. Descriptive statistics clinical tumor data, as well overall (OS) recurrence-free (RFS)...
Magnetic resonance imaging (MRI) is the preferred modality for oropharyngeal cancers (OPCs), but it has difficulties distinguishing between small OPCs and unilateral tonsil hypertrophy. We hypothesized that surgeon-performed transoral ultrasound (US) could be used to accurately detect T-stage OPCs. performed a single-center prospective diagnostic accuracy study including patients with suspected or biopsy-verified during outpatient appointments. All were offered US MRI. If not tolerated by...
This study protocol for a prospective, multicenter, diagnostic, clinical trial describes the integration of transoral and transcervical ultrasonography (US) in initial work-up patients referred to tertiary head neck cancer centers with suspected oropharyngeal cancer. The evaluates blinded detection rate tumors their US-estimated size T-stage before histopathology cross-sectional imaging are available. Magnetic resonance (MRI) scans will be prospectively rated while T-site US. primary outcome...
Second primary cancer (SPC) is the second most common cause of death among patients diagnosed with head and neck cancer. This study examined risk SPC following oropharyngeal squamous cell carcinoma (OPSCC) impact human papillomavirus (HPV) on survival SPC. The was a population-based, retrospective including all OPSCC in eastern Denmark from 2000–2020 who received curative intended treatment. incidence rate ratio (IRR), age-adjusted rates (AAIR), hazard ratios (HR) were calculated. A total...
Background: Persistent infection with high-risk genotypes of human papillomavirus (HPV) is the main risk factor in development uterine cervical precancerous lesions and cancer (CC), cases HPV-induced oropharyngeal squamous cell carcinoma (OPSCC) increasing Western world. We investigated association between HPV p16 status previous results examinations, including cytological histological tests, females OPSCC.Material Methods: included diagnosed an OPSCC Eastern Denmark from 2000 to 2014....
Abstract Background Isolated regional recurrences following head‐neck squamous‐cell carcinomas (HNSCC) are often accessible for curatively intended salvage treatment. Factors prognostic outcome were investigated in a large cohort of HNSCC patients. Methods In total, 1811 patients receiving radiotherapy from 2007 to 2017 reviewed and isolated cervical nodal identified. associated with survival second recurrence using univariate multivariate analyses. Results was seen 95/1811 (5.2%) Eighty 95...
This CME article explores the evolving role of endosonography in otorhinolaryngology and head neck surgery. Endosonography offers significant potential to improve imaging inside upper respiratory tract, particularly with advancements probe technology resolution. The will describe sonoanatomy oral cavity, pharynx, larynx selection probes scanning techniques used for various anatomical sites. Transoral ultrasound can be diagnosis salivary gland diseases, oropharyngeal abscesses,...
This case report describes an extremely early-onset of human papillomavirus–positive oropharyngeal squamous cell carcinoma in a Norwegian woman her early 20s.