A5010676985- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Advanced Radiotherapy Techniques
- Cervical Cancer and HPV Research
- Head and Neck Surgical Oncology
- Viral-associated cancers and disorders
- Esophageal Cancer Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Oral health in cancer treatment
- Radiation Therapy and Dosimetry
- Cancer-related molecular mechanisms research
- Cancer Diagnosis and Treatment
- Ear and Head Tumors
- Indigenous Studies and Ecology
- Global Cancer Incidence and Screening
- Medical Imaging Techniques and Applications
- Colorectal and Anal Carcinomas
- Advances in Oncology and Radiotherapy
- Tracheal and airway disorders
- Dysphagia Assessment and Management
- Salivary Gland Tumors Diagnosis and Treatment
- Cleft Lip and Palate Research
Copenhagen University Hospital
2016-2025
Rigshospitalet
2016-2025
Centre for Cosmology and Particle Physics Phenomenology
2019-2024
Aarhus University Hospital
2019-2024
University of Copenhagen
2014-2023
Herlev Hospital
2022
Government of the Republic of Korea
2020
UW Health University Hospital
2017
University of Wisconsin–Madison
2017
University Health Network
2012
Intratumor heterogeneity may contribute to the ambiguous clinical results on PD-L1 status as a predictor for immunotherapy response in patients with HNSCC. This decreases utility of expression from single tumour biopsies predictive biomarker. In this prospective study, intratumor HNSCC was investigated both Tumour Proportion Score (TPS) and Combined Positive (CPS). Thirty-three whole surgical specimens 28 were included. six random core each specimen used assess concordance between multiple...
ObjectivesTo determine and compare the incidence of cancer among 8 Arctic States their northern regions, with special focus on 3 cross-national indigenous groups – Inuit, Athabaskan Indians Sami.MethodsData were extracted from national regional statistical agencies registries, direct age-standardization rates to world standard population. For comparison, "world average" as reported in GLOBOCAN database used.FindingsAge-standardized by sites computed for 20 averaged over decade 2000–2009....
IntroductionProton treatment can potentially spare patients with H&N cancer for substantial treatment-related toxicities. The current study investigated the reproducibility of a decentralised model-based selection proton when plans were compared to clinical performed at centre.MethodsSixty-three selected in six Danish Head and Neck Cancer (DAHANCA) centres. based on normal tissue complication probability (NTCP) estimated from local photon plans, which showed ΔNTCP greater than 5%-point...
No effective treatment exists for radiation-induced xerostomia. The objective of this study was to compare the effect adipose-derived mesenchymal stem/stromal cell (ASC) injection, relative placebo, on salivary gland function in patients with
This is the second of 2 papers reporting on result Circumpolar Inuit Cancer Review, an international collaborative effort involving researchers and health officials from Alaska, Canada Greenland.Inuit cancer cases by age-sex group anatomic site were obtained regional registries.Cancer in general increasing among Inuit, all regions, both men women. continue to be at extreme high risk, relative non-Inuit comparisons global populations, for historically recognized so-called traditional cancers...
To evaluate the accuracy of cell-free human papillomavirus-DNA (cfHPV-DNA) measurements in liquid biopsies predicting disease patients with HPV-positive/p16-positive (HPV+/p16+) oropharyngeal squamous cell carcinoma (OPSCC).This was a prospective cohort study. Plasma samples were collected before treatment, serially after curative intended therapy at follow-up visits 2 weeks, and 6, 9, 12, 18, 24, 30 months treatment. A droplet digital PCR assay comprising eight HPV genotypes used. found...
Denmark, alongside other Scandinavian countries, the United States, Canada, and Kingdom, has high prevalence of human papillomavirus (HPV). Our oropharyngeal squamous cell carcinoma (OPSCC) database includes all diagnosed cases in Eastern Denmark during a period more than two decades. We investigated incidence, survival, recurrence patients with OPSCC combined p16- HPV testing covering consecutive 21-year period. Age-adjusted incidence rate (AAIR) per 100,000, survival models, Cox...
Abstract Background: The long-term effect of adipose-derived mesenchymal stromal cells (ASCs) to restore radiation-induced salivary gland hypofunction in previous head and neck cancer patients have not been validated larger settings. Methods: study was the 12-months follow-up a randomised trial, including with hyposalivation. Patients were receive allogeneic ASCs or placebo submandibular glands. Primary endpoint unstimulated whole saliva (UWS) followed by stimulated saliva, patient-reported...
Background and purpose: The randomised clinical trial KEYNOTE-048 has demonstrated a significant increase in survival for patients with head neck cancer treated pembrolizumab or without chemotherapy. purpose of the present retrospective study was to investigate whether group consecutive at our department comparable results from KEYNOTE-048. Patients/material methods: Seventy-six initiated treatment ± platinum/5-FU between July 2020 May 2022. Baseline characteristics were collected, response...
ABSTRACT Background A previously published failure‐type specific risk model showed good performance in the original cohort. Aim: to validate and separate patients with high‐ low‐risk loco‐regional failure (LRF). Goal: identify potentially suitable for treatment intensification trials. Methods Validation data: 756 from two institutions (different countries). Predictive was evaluated by Brier scores AUCs. Discriminatory compared Union International Cancer Control (UICC) staging (versions 7 8)....
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<div>AbstractPurpose:<p>The long-term effect of adipose-derived mesenchymal stromal cells (ASC) on restoring radiation-induced salivary gland hypofunction in patients with previous head and neck cancer has not been validated larger settings.</p>Patients Methods:<p>The study was a 12-month follow-up randomized trial, including hyposalivation. Patients were to receive allogeneic ASC or placebo the submandibular glands. The primary endpoint unstimulated whole saliva...
Abstract Undifferentiated nasopharyngeal carcinoma is a result of environmental factors, in particular EBV infection, affecting genetically susceptible individuals. The familial risk among the highest any malignancy. Whether this susceptibility restricted to unknown as information on other cancers relatives limited. We did population-based study cancer incidence families Greenland, carcinoma–endemic area. Using registers, cohort all persons born Greenland was followed from 1973 2002. In...
Abstract BACKGROUND Nasopharyngeal carcinoma (NPC) is a rare disease in most populations; however, areas of Southeast Asia and North Africa the Arctic, undifferentiated NPC frequent pharyngeal malignancy. Although smoking alcohol have been established firmly as synergistic risk factors for other carcinomas, previous studies on association between these not consistent. Therefore, authors analyzed this relation cohort Singapore Chinese, which population with high incidence NPC. METHODS From...
Abstract BACKGROUND. Incense use is an integral part of daily life in large parts Asia. The burning incense a powerful producer particulate matter and the smoke contains multitude well‐characterized carcinogens. However, to authors' knowledge, no convincing association has been reported between exposure development cancer. Therefore, relation risk respiratory tract carcinomas was analyzed prospective cohort study. METHODS. Between 1993 1998, population‐based 61,320 Singapore Chinese who were...