A5041460528- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Advances in Oncology and Radiotherapy
- Colorectal and Anal Carcinomas
- Management of metastatic bone disease
- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Advanced X-ray and CT Imaging
- Digital Radiography and Breast Imaging
- Prostate Cancer Diagnosis and Treatment
- Radiation Effects and Dosimetry
- Bladder and Urothelial Cancer Treatments
- Medical Imaging and Pathology Studies
- Brain Metastases and Treatment
- Oral health in cancer treatment
- Glioma Diagnosis and Treatment
- Radiation Detection and Scintillator Technologies
- Radiation Dose and Imaging
- Cancer, Hypoxia, and Metabolism
- Artificial Intelligence in Healthcare and Education
Gentofte Hospital
2017-2024
University of Copenhagen
2014-2024
Herlev Hospital
2014-2024
Copenhagen University Hospital
2023-2024
Technical University of Denmark
2015-2018
Studies have demonstrated the potential of online adaptive radiotherapy (oART). However, routine use has been limited due to resource demanding solutions. This study reports on experiences with oART in pelvic region using a novel cone-beam computed tomography (CBCT)-based, artificial intelligence (AI)-driven solution.Automated pre-treatment planning for thirty-nine cases (bladder, rectum, anal, and prostate), one hundred simulations were conducted pre-clinical release Ethos (Varian Medical...
Online adaptive radiotherapy (oART) potentially reduces the dose to organs at risk (OARs) as planning target volume (PTV) margins are reduced compared a non-adaptive approach (non-ART). This study evaluates feasibility and dosimetric impact of cone-beam computed tomography (CBCT)-guided oART urinary bladder cancer for first patients treated, using patient-specific margins.Sixteen consecutive with muscle-invasive received two or more (median = 23) fractions oART, remaining non-ART. The...
IntroductionProton treatment can potentially spare patients with H&N cancer for substantial treatment-related toxicities. The current study investigated the reproducibility of a decentralised model-based selection proton when plans were compared to clinical performed at centre.MethodsSixty-three selected in six Danish Head and Neck Cancer (DAHANCA) centres. based on normal tissue complication probability (NTCP) estimated from local photon plans, which showed ΔNTCP greater than 5%-point...
The Ethos system has enabled online adaptive radiotherapy (oART) by implementing an automated treatment planning (aTPS) for both intensity-modulated (IMRT) and volumetric modulated arc (VMAT) plan creation. purpose of this study is to evaluate the quality aTPS plans in pelvic region.Sixty patients with anal (n = 20), rectal 20) or prostate cancer were retrospectively re-planned aTPS. Three IMRT (7-, 9- 12-field) two VMAT (2 3 arc) automatically generated (APs) created per patient. duration...
Online adaptive radiotherapy (oART) potentially spares OARs as PTV margins are reduced. This study evaluates dosimetric benefits, compared to standard non-adaptive (non-ART), target propagation methods, and first clinical treatments of CBCT-guided oART anal cancer.Treatment plans with non-ART reduced were retrospectively generated for 23 consecutive patients cancer. For five randomly selected among the patients, weekly sessions simulated, where targets either deformed or rigidly propagated....
AbstractBackground In the Danish Head and Neck Cancer Group (DAHANCA) 35 trial, patients are selected for proton treatment based on simulated reductions of Normal Tissue Complication Probability (NTCP) compared to photon at referring departments. After inclusion in immobilization, scanning, contouring planning repeated national centre. The new contours could result reduced expected NTCP gain plan, resulting a loss validity selection process. present study evaluates if contour consistency can...
Radiotherapy of lung cancer patients is subject to uncertainties related heterogeneities, anatomical changes and breathing motion. Use deep-inspiration breath-hold (DIBH) can reduce the treated volume, potentially enabling dose-escalated (DE) treatments. This study was designed investigate need for adaptation due changes, both standard (ST) DE plans in free-breathing (FB) DIBH.The effect tumor shrinkage (TS), pleural effusion (PE) atelectasis investigated a CIRS thorax phantom. Sixteen were...
Abstract Background Chemo-radiotherapy with curative intent for anal cancer has high complete remission rates, but acute treatment-related gastrointestinal (GI) toxicity is significant. Toxicity occurs due to irradiation of surrounding normal tissue. Current radiotherapy requires the addition large planning margins radiation field ensure target coverage regardless considerable organ motion in pelvic region. This increases irradiated volume and dose tissue thereby toxicity. Online adaptive...
Daily target re-delineation in online adaptive radiotherapy (oART) introduces uncertainty. The aim of this study was to evaluate artificial intelligence (AI) generated contours and inter-observer variation among technicians cone-beam CT (CBCT) guided oART bladder cancer.
The purpose of this study was to evaluate our 2 years' experience with single-isocenter, non-coplanar, volumetric modulated arc therapy (VMAT) for brain metastasis (BM) stereotactic radiosurgery (SRS).A total 202 patients treated the VMAT SRS solution were analyzed retrospectively. Plan quality assessed 5 mm (120) and 2.5 (high-definition, HD) central leaf width multileaf collimators (MLCs). For BMs at varying distances from plan isocenter, geometric offset ideal position two image-guided...
Background and purpose: As preparation for a national randomized study comparing proton radiotherapy to photon radiotherapy, DAHANCA 35, we performed non-randomized pilot investigate patient selection, logistics, planning, treatment delivery. With the present study, as comprehensive safety analysis, want compare toxicity during up two months after therapy historically matched group of patients treated with radiotherapy. Materials methods: 62 protons were 124 who received outside protocol....
Pancreatic cancer is one of the most challenging tumor sites to treat safely and effectively with radiotherapy due anatomical location aggressiveness disease. One modality that has shown promising results, which our institution been employing, online adaptive stereotactic using a magnetic resonance-guided linear accelerator (MR-linac). However, unforeseen circumstances regarding MR-linac, it was necessary for use an alternative treatment technique. In this case report, we describe experience...