A5029644950- Advanced Radiotherapy Techniques
- Radiation Detection and Scintillator Technologies
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Radiation Effects and Dosimetry
- Nuclear Physics and Applications
- Radioactivity and Radon Measurements
- Nuclear and radioactivity studies
- Radiation Dose and Imaging
- Luminescence Properties of Advanced Materials
- Effects of Radiation Exposure
- Radioactive contamination and transfer
- Graphite, nuclear technology, radiation studies
- Advanced MRI Techniques and Applications
- Digital Radiography and Breast Imaging
- Advanced X-ray and CT Imaging
- Nuclear reactor physics and engineering
- Atmospheric and Environmental Gas Dynamics
- Noise Effects and Management
- Radiation Effects in Electronics
- Spectroscopy Techniques in Biomedical and Chemical Research
- Ion-surface interactions and analysis
- Soil and Unsaturated Flow
- Particle Detector Development and Performance
- Ultrasound and Hyperthermia Applications
Technical University of Denmark
2016-2025
UPMC Health System
2019-2020
Johns Hopkins University
2019-2020
Swedish Medical Center
2018-2020
American Association of Physicists in Medicine
2017-2020
John Wiley & Sons (United States)
2018-2020
Ashland (United States)
2017-2020
Duke Medical Center
2020
Philips (Finland)
2020
Radiation Oncology Associates
2008-2019
PurposePreclinical studies have shown a preferential normal tissue sparing effect of FLASH radiotherapy with ultra-high dose rates. The aim the present study was to use murine model acute skin toxicity investigate biological varying rates, time structure, and introducing pauses in delivery.Materials MethodsThe right hind limbs non-anaesthetized mice were irradiated entrance plateau PBS proton beam 39.3 Gy. Experiment 1 field rates (0.7- 80 Gy/s) without repainting, 2 (0.37- 3 where split...
Purpose: The aim of the present study is to provide a comprehensive set detector specific correction factors for beam output measurements small beams, wide range real time and passive detectors. determined in this may be potentially useful as reference data dosimetry measurements. Methods: Dose response detectors was investigated field sizes shaped with micromultileaf collimator ranging from 0.6 × cm2 4.2 were extended larger fields up 10 cm2. Measurements performed at 5 cm depth, 6 MV...
Previous calculations of the γ dose given to Risø Calibration Quartz (RCQ) were performed using mass absorption and attenuation coefficients. In this paper, we update RCQ Geant4 simulations provide a comparison with three other sources in Denmark. We also show experimental evidence that luminescence response a137Cs irradiation is 4% higher than resulting from a60Co for same dose, confirming suggestions Autzen et al. (2021) based on simulations.
A new optical-fibre radiation dosimeter system, based on radioluminescence and optically stimulated luminescence from carbon-doped aluminium oxide, was developed tested in clinical photon beams. This prototype offers several features, such as a small detector (1 x 1 2 mm3), high sensitivity, real-time read-out the ability to measure both dose rate absorbed dose. The measurements describing reproducibility output dependence rate, field size energy all had standard deviations smaller than 1%....
A prototype of a new dose-verification system has been developed to facilitate prevention and identification dose delivery errors in remotely afterloaded brachytherapy. The allows for automatic online vivo dosimetry directly the tumor region using small passive detector probes that fit into applicators such as standard needles or catheters. measures absorbed rate (0.1 s time resolution) total on basis radioluminescence (RL) optically stimulated luminescence (OSL) from aluminum oxide crystals...
Submarine groundwater discharge (SGD) from subseafloor aquifers, through muddy sediments, was studied in Eckernförde Bay (western Baltic Sea). The fluid clearly traced by 222Rn enrichment the water column and chloride profiles pore water. At several sites, a considerable decrease chloride, to levels less than 10% of bottom‐water concentrations, observed within upper few centimeters sediment. Studies at 196 sites revealed that >22% seafloor bay area affected freshwater admixture active...
The purpose of this study is to present and evaluate a dose-verification protocol for pulsed dose-rate (PDR) brachytherapy based on in vivo time-resolved (1 s time resolution) fiber-coupled luminescence dosimetry.Five cervix cancer patients undergoing PDR (Varian GammaMed Plus with 192Ir) were monitored. treatments comprised from 10 50 pulses pulse/h) delivered by intracavitary/interstitial applicators (tandem-ring systems and/or needles). For each patient, one or two dosimetry probes placed...
The IAEA is currently coordinating a multi-year project to update the TRS-398 Code of Practice for dosimetry external beam radiotherapy based on standards absorbed dose water. One major aspect determination new quality correction factors, k Q , megavoltage photon beams consistent with developments in and technology since publication 2000. Specifically, all values must be on, or with, key data ICRU Report 90. Data sets obtained from Monte Carlo (MC) calculations by advanced users measurements...
A favorable effect of ultra-high dose rate (FLASH) radiation on normal tissue-sparing has been indicated in several preclinical studies. In these studies, the adverse effects damage were reduced without compromising tumor control. Most studies proton FLASH investigate within entrance a beam. However, real advantage therapy lies Spread-out Bragg Peak (SOBP), which allows for giving high to target with limited healthy tissue at Therefore, clinically relevant investigation would be tissues...
Dose-response modification of FLASH has previously been established for acute skin toxicity in protons. This study used a similar experimental setup to quantify the dose-response electron irradiation skin- and late fibrotic mice. The similarity enabled quantitative comparison response electrons Female unanaesthetised C3D2F1 mice were restrained with right hindleg fixated submerged water bath horizontal at 16 MeV. Mice randomised groups varying single doses (19.4-57.6 Gy) irradiated either...
Although the radioluminescence (RL) signal from optical fibre Al(2)O(3):C dosemeters used in medical applications is essentially proportional to dose rate, crystals so far are imperfect sense that their RL sensitivity changes with accumulated dose. A computational algorithm has been developed corrects for these changes. We further report on a new system effectively separates generated crystal fluorescence and Cerenkov emission cable using gating technique connection pulsed linear accelerator...
Interoperability of charging infrastructures is a key success factor for E-Mobility. Standards like ISO/IEC 15118 and IEC 61851-1 are developed to ensure base level interoperability front-end com- munication signaling processes smart between electric vehicles charge spots. With the Open Charge Point Protocol (OCPP) forum European industry members also moves towards common back-end protocol spots intending reduce secure overall investment costs. However, in current form OCPP lacks means...
A dosimetry system based on radioluminescence (RL) and optically stimulated luminescence (OSL) from carbon doped aluminium oxide (Al2O3:C) crystals was developed for in vivo absorbed dose measurements mammography. small cylindrical crystal of Al2O3:C (diameter 0.48 mm length 2 mm) coupled to the end a 1 diameter optical fibre cable. Owing their size characteristic shape, these probes can be placed body surface field view during examination, without compromising reading mammogram. Our new...
Background Increased brain tumour incidence over recent decades may reflect improved diagnostic methods and clinical practice, but remain unexplained. Although estimated doses are low a relationship between radon tumours exist. Objective To investigate the long-term effect of exposure to residential on risk primary in prospective Danish cohort. Methods During 1993–1997 we recruited 57,053 persons. We followed each cohort member for cancer occurrence from enrolment until 31 December 2009,...