A5085769393- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Radiation Detection and Scintillator Technologies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Advanced MRI Techniques and Applications
- Radiation Dose and Imaging
- Cancer Diagnosis and Treatment
- Radiation Effects and Dosimetry
- Advances in Oncology and Radiotherapy
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Prostate Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- MRI in cancer diagnosis
- Advanced X-ray and CT Imaging
- Ultrasound Imaging and Elastography
- Colorectal Cancer Surgical Treatments
- Effects of Radiation Exposure
- Hepatocellular Carcinoma Treatment and Prognosis
- Endometrial and Cervical Cancer Treatments
- Cancer Genomics and Diagnostics
Copenhagen University Hospital
2009-2025
Technical University of Denmark
2022-2025
Gentofte Hospital
2017-2024
Herlev Hospital
2010-2023
University of Copenhagen
1998-2021
Thoracic Surgery Foundation
2017
The University of Texas MD Anderson Cancer Center
2017
Novo Nordisk (Denmark)
2016
University of Surrey
2015
Lund University
2009-2011
Studies have demonstrated the potential of online adaptive radiotherapy (oART). However, routine use has been limited due to resource demanding solutions. This study reports on experiences with oART in pelvic region using a novel cone-beam computed tomography (CBCT)-based, artificial intelligence (AI)-driven solution.Automated pre-treatment planning for thirty-nine cases (bladder, rectum, anal, and prostate), one hundred simulations were conducted pre-clinical release Ethos (Varian Medical...
Abstract Purpose The purpose of the study was to investigate if surface guided radiotherapy (SGRT) can decrease setup deviations for tangential and locoregional breast cancer patients compared conventional laser‐based (LBS). Materials Methods Both (63 patients) (76 were enrolled in this study. For LBS, positioned by aligning skin markers room lasers. based (SBS), an optical scanning system used daily using both single three camera systems. To compare two methods, patient position evaluated...
To evaluate the clinical benefit of nivolumab with or without ipilimumab in combination stereotactic body radiotherapy (SBRT) patients refractory metastatic pancreatic cancer (mPC).Between November 2016 and December 2019, mPC were randomly assigned 1:1 to SBRT 15 Gy nivolumab/ipilimumab stratified by performance status (ClinicalTrials.gov identifier: NCT02866383). The primary end point was rate (CBR), defined as percentage complete partial response (PR) stable disease, according RECIST 1.1....
Online adaptive radiotherapy (oART) potentially reduces the dose to organs at risk (OARs) as planning target volume (PTV) margins are reduced compared a non-adaptive approach (non-ART). This study evaluates feasibility and dosimetric impact of cone-beam computed tomography (CBCT)-guided oART urinary bladder cancer for first patients treated, using patient-specific margins.Sixteen consecutive with muscle-invasive received two or more (median = 23) fractions oART, remaining non-ART. The...
Purpose: With the increased commercial availability of intensity modulated arc therapy (IMAT) comes need for comprehensive QA programs, covering different aspects this newly available technology. This manuscript proposes such a program RapidArc (RA) (Varian Medical Systems, Palo Alto) IMAT solution. Methods: The was developed and tested out Millennium120 MLC on iX Clinacs HighDefinition Novalis TX, using variety measurement equipment including Gafchromic film, 2D ion chamber arrays (Seven29...
The Ethos system has enabled online adaptive radiotherapy (oART) by implementing an automated treatment planning (aTPS) for both intensity-modulated (IMRT) and volumetric modulated arc (VMAT) plan creation. purpose of this study is to evaluate the quality aTPS plans in pelvic region.Sixty patients with anal (n = 20), rectal 20) or prostate cancer were retrospectively re-planned aTPS. Three IMRT (7-, 9- 12-field) two VMAT (2 3 arc) automatically generated (APs) created per patient. duration...
Online adaptive radiotherapy (oART) potentially spares OARs as PTV margins are reduced. This study evaluates dosimetric benefits, compared to standard non-adaptive (non-ART), target propagation methods, and first clinical treatments of CBCT-guided oART anal cancer.Treatment plans with non-ART reduced were retrospectively generated for 23 consecutive patients cancer. For five randomly selected among the patients, weekly sessions simulated, where targets either deformed or rigidly propagated....
The flexibility in radiotherapy can be improved if a patient moved between any one of the department's medical linear accelerators without need to change anything patient's treatment plan. For this possible, dosimetric characteristics various must same, or nearly same i.e. beam-matched.During period nine months, eight Varian iX with 6 and 15 MV photon beams 6–18 MeV electron (only four eight) were installed at our clinic. All fulfilled vendor-defined "fine beam-match" criteria, more...
MR-guided radiotherapy (MRgRT) allows real-time beam-gating to compensate for intra-fractional target position variations. This study investigates the dosimetric impact of and PTV margin on prostate coverage cancer patients treated with online-adaptive MRgRT.20 consecutive were MRgRT SBRT 36.25 Gy in 5 fractions (PTV D95% ≥ 95% (N = 5) 100% 15)). Sagittal 2D cine MRIs used gating a 3 mm expansion as window. We computed motion-compensated dose distributions (i) all positions during treatment...
The presence of histological variants haemangioblastoma is well established, but data on the prognostic implications subtyping are missing. We thus characterized clinical factors associated with subtypes, that is, cellular and reticular variant haemangioblastoma, in a series 88 consecutive primary haemangioblastomas central nervous system. Ten were classified as 'cellular' according to Cushing Bailey. As compared more common 'reticular' (n = 78), proportion tumours containing glial...
Early diagnosis of necrotising enterocolitis (NEC) is difficult but essential for timely therapy. The diagnostic hallmarks and specific radiological signs NEC are pneumatosis intestinalis (PI) portal venous gas (PVG), PVG in abdominal ultrasound (PVG-US) has been proposed as an effective tool the well.To prospectively assess value PVG-US NEC.The study screened 352 neonates (n = 796 routine examinations) performed 48 additional screenings 34/352 with suspected (stage I, n 28) or definite >...
Pareto optimality is a concept that formalises the trade-off between given set of mutually contradicting objectives. A solution said to be optimal when it not possible improve one objective without deteriorating at least other. solutions constitute front. The applies well inverse planning process, which involves inherently contradictory objectives, high and uniform target dose on hand, sparing surrounding tissue nearby organs risk (OAR) Due specific characteristics treatment system (TPS),...
The use of magnetic resonance (MR) imaging as a part preparation for radiotherapy is increasing. For delineation the prostate several publications have shown decreased variability using MR compared to computed tomography (CT). purpose present work was investigate intra- and inter-physician seminal vesicles, influence different sequence settings used clinically at five centers participating in study. series from centers, each providing patients, were used. Two physicians center delineated...
A fast-readout dosimetry system based on fibre-coupled organic scintillators has been developed for the purpose of conducting point measurements absorbed dose in radiotherapy beams involving high spatial and temporal gradients. The measures each linac radiation pulse with millimetre resolution. To demonstrate applicability complex fields, output factors per cent depth were performed solid water a 6 MV photon beam compared Monte Carlo simulated doses square fields down to 0.6 cm × size. No...
In prostate radiotherapy, it is essential that the position within planned volume during treatment delivery. The aim of this study to investigate whether intrafractional motion clinical consequence, using a novel 4D autoscan ultrasound probe.Ten patients were (US) scanned at time CT imaging and once week their course radiotherapy in an ethics-approved study, transperineal Clarity system (Clarity®, Elekta Inc., Stockholm, Sweden). At each US scanning session (fraction) was monitored for 2 2.5...
One of the newest developments within radiotherapy is integration Magnetic Resonance (MR) scanners and Megavoltage X-rays from linear accelerators into new MR-Linacs.Some MR-Linacs are able to perform gated treatments based on continuously acquired 2D MR images taken during dose delivery, which has potential reduce margins required for tumor coverage.We have developed a dosimetry system that can provide time-resolved, dose-per-pulse, without distorting in order characterize this...
Background and purposeDaily plan adaptations could take the dose delivered in previous fractions into account. Due to high per fraction, low number of fractions, steep gradients, large interfractional organ deformations, this might be particularly important for liver SBRT. This study investigates inter-algorithm variation accumulation MR-guided SBRT.Materials methodsWe assessed 27 consecutive SBRT treatments 67.5 Gy three (n = 15) or 50 five 12), both prescribed GTV. We calculated fraction...
The pencil beam dose calculation method is frequently used in modern radiation therapy treatment planning regardless of the fact that it documented inaccurately for cases involving large density variations. inaccuracies are larger higher energies. As a result, low energy beams conventionally lung treatments. aim this study was to analyze advantages and disadvantages dynamic IMRT high photon order assess if deviating from conventional approach could be favorable some cases. Furthermore,...
The aim of this study is to evaluate the patient setup accuracy by investigating impact different types CBCT matches, performed with 3 (translations only) or 6 (including rotations) degrees-of-freedom (DOF). purpose also calculate and compare CTV PTV margins based on various setups using 2D kV planar imaging skin markers only (non-IGRT).Setup images from 16 NSCLC patients weekly daily were analyzed retrospectively. matches columna vertebralis (CV), whole thorax (WT) soft tissue (ST)...
The aim of this study was to carry out geometric and dosimetric evaluation the usefulness a deformable image registration algorithm utilized for adaptive head-and-neck intensity-modulated radiotherapy. Data consisted seven patients, each with planning CT (pCT), rescanning (ReCT) cone beam (CBCT). CBCT acquired on same day (± 1 d) as ReCT (i.e. at Fraction 17, 18, 23, 24 or 29). served ground truth. A deformed (dCT) structures created by deforming pCT CBCT. geometrical comparison based...