A5030711816- Advanced Radiotherapy Techniques
- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Radiomics and Machine Learning in Medical Imaging
- Advances in Oncology and Radiotherapy
- Lung Cancer Treatments and Mutations
- Solid State Laser Technologies
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Photonic and Optical Devices
- Head and Neck Surgical Oncology
- Advanced MRI Techniques and Applications
- Tracheal and airway disorders
- Photorefractive and Nonlinear Optics
- Cardiac Imaging and Diagnostics
- Dysphagia Assessment and Management
- MRI in cancer diagnosis
- Advanced X-ray and CT Imaging
- Scientific Computing and Data Management
- Ear and Head Tumors
- Digital Radiography and Breast Imaging
- Management of metastatic bone disease
- Photodynamic Therapy Research Studies
- Photonic Crystal and Fiber Optics
Zealand University Hospital
2022-2024
Aarhus University Hospital
2019-2023
Zealand University Hospital Køge
2023
Herlev Hospital
2012-2022
Næstved Sygehus
2022
University of Copenhagen
2014-2020
Copenhagen University Hospital
2011-2019
Centre for Cosmology and Particle Physics Phenomenology
2019
Gentofte Hospital
2017
Nordic Laboratory for Luminescence Dating
2001-2005
Purpose: With the increased commercial availability of intensity modulated arc therapy (IMAT) comes need for comprehensive QA programs, covering different aspects this newly available technology. This manuscript proposes such a program RapidArc (RA) (Varian Medical Systems, Palo Alto) IMAT solution. Methods: The was developed and tested out Millennium120 MLC on iX Clinacs HighDefinition Novalis TX, using variety measurement equipment including Gafchromic film, 2D ion chamber arrays (Seven29...
IntroductionProton treatment can potentially spare patients with H&N cancer for substantial treatment-related toxicities. The current study investigated the reproducibility of a decentralised model-based selection proton when plans were compared to clinical performed at centre.MethodsSixty-three selected in six Danish Head and Neck Cancer (DAHANCA) centres. based on normal tissue complication probability (NTCP) estimated from local photon plans, which showed ΔNTCP greater than 5%-point...
Reliable and accessible biomarkers for patients with Head Neck Squamous Cell Carcinoma (HNSCC) are warranted biologically driven radiotherapy (RT). This study aimed to investigate the prognostic value of putative cancer stem cell (CSC) markers, hypoxia, tumor volume using loco-regional high-dose failure (HDF) as endpoint.
Previously, many radiotherapy (RT) trials were based on a few selected dose measures. Many research questions, however, rely access to the complete information. To support such access, national RT plan database was created. The system focuses data security, ease of use, and re-use data. This article reports development structure, functionality experience this database.A DICOM-RT standard, DcmCollab, implemented with direct connections all Danish centres. Data is segregated into any number...
Introduction: Prediction models using logistic regression may perform poorly in external patient cohorts. However, there is a need to standardize and validate for clinical use. The purpose of this project was describe method validation NTCP used selection the randomized trial protons versus photons head neck cancer radiotherapy, DAHANCA 35.Material methods: Organs at risk 588 patients treated primarily with IMRT controlled DAHANCA19 were retrospectively contoured according recent...
AbstractBackground In the Danish Head and Neck Cancer Group (DAHANCA) 35 trial, patients are selected for proton treatment based on simulated reductions of Normal Tissue Complication Probability (NTCP) compared to photon at referring departments. After inclusion in immobilization, scanning, contouring planning repeated national centre. The new contours could result reduced expected NTCP gain plan, resulting a loss validity selection process. present study evaluates if contour consistency can...
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IntroductionPatients with failure after primary radiotherapy (RT) for head and neck squamous cell carcinoma (HNSCC) have a poor prognosis. This study investigates pattern of curatively intended IMRT in randomized controlled trial relation to HPV/p16 status.Material methodsPatients HNSCC the oral cavity, oropharynx (OPSCC), hypopharynx or larynx were treated curative (±cisplatin) concomitant nimorazole between 2007 12. Of 608 patients, 151 had loco-regional within five years, from whom 130...
The aim of this study was to carry out geometric and dosimetric evaluation the usefulness a deformable image registration algorithm utilized for adaptive head-and-neck intensity-modulated radiotherapy. Data consisted seven patients, each with planning CT (pCT), rescanning (ReCT) cone beam (CBCT). CBCT acquired on same day (± 1 d) as ReCT (i.e. at Fraction 17, 18, 23, 24 or 29). served ground truth. A deformed (dCT) structures created by deforming pCT CBCT. geometrical comparison based...
AbstractBackground As magnetic resonance imaging (MRI) becomes increasingly integrated into radiotherapy (RT) for enhanced treatment planning and adaptation, the inherent geometric distortion in acquired MR images pose a potential challenge to accuracy. This study aimed evaluate levels clinical MRI protocols used across Danish RT centers discuss influence of specific sequence parameters. Based on variety performance centers, we assess if harmonization sequences is relevant measure.Materials...
The study aimed to investigate the pattern of failure and describe compromises in definition coverage target for patients treated with curatively intended radiotherapy (RT) sinonasal cancer (SNC).Patients RT 2008-2015 Denmark SNC were eligible retrospective cohort study. Information regarding diagnosis treatment was retrieved from national database Danish Head Neck Cancer Group (DAHANCA). Imaging recurrences collected, point origin (PO) recurrent tumour estimated. All plans collected...
MRI (magnetic resonance imaging) scans are frequently used in follow-up after radiotherapy for head and neck cancer. With the overall aim of enabling MRI-based pattern failure analysis, this study evaluated accuracy recurrence (rMRI) deformable co-registration with planning CT (computed tomography)-scans (pCT). Uncertainty anatomical changes between pCT rMRI was assessed by similarity metric analyses co-registered image structures from 19 patients. Average mean distance to agreement Dice...
We propose that self-pumped degenerate four-wave mixing may be used to produce novel diode laser systems where lasing is based on nonlinear guiding of the beams inside active semiconductor. The fundamental process responsible for interaction spatial hole burning in semiconductor amplifiers. gain and index gratings created by modulation carrier density medium lead selective amplification one mode suppression all other modes. This mechanism allows system operated far above its threshold with...
Purpose/Objective: Our clinic is a long-term user of 1st generation trans-abdominal (TA) ultrasound image guidance (USIG) system (BAT, Best Nomos Inc) for prostate cancer treatments.We are also an early adopter and development partner new, second 3D USIG (Clarity, Elekta Inc), which allows trans-perineal (TP) localization intra-fractional tracking the prostate.This new has been evaluated at our institution, by direct comparison with previously established TA method alignment.Materials...
Introduction: Treatment planning using a five-millimetre geometrical margin from GTV to high-dose CTV (CTV1) has been used in DAHANCA treatment centres since 2013. We aimed evaluate changes CTV1 volumes, local control (LC), and recurrence pattern after the implementation of margins nationally.Materials Methods: 1,948 patients with pharyngeal, laryngeal squamous cell carcinomas completed definitive IMRT-based 2010-2012 2013-2015 three centres. The patient-specific was calculated as median...
Background and purpose: As preparation for a national randomized study comparing proton radiotherapy to photon radiotherapy, DAHANCA 35, we performed non-randomized pilot investigate patient selection, logistics, planning, treatment delivery. With the present study, as comprehensive safety analysis, want compare toxicity during up two months after therapy historically matched group of patients treated with radiotherapy. Materials methods: 62 protons were 124 who received outside protocol....