A5073947915- Advanced Radiotherapy Techniques
- Breast Cancer Treatment Studies
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Cancer Risks and Factors
- Chemotherapy-induced cardiotoxicity and mitigation
- Effects of Radiation Exposure
- Radiation Therapy and Dosimetry
- Cardiac Imaging and Diagnostics
- Advances in Oncology and Radiotherapy
- Global Cancer Incidence and Screening
- Advanced X-ray and CT Imaging
- Breast Implant and Reconstruction
- Head and Neck Cancer Studies
- Thyroid Cancer Diagnosis and Treatment
- Medical Imaging and Analysis
- Brain Tumor Detection and Classification
- Lung Cancer Treatments and Mutations
- Functional Brain Connectivity Studies
- MRI in cancer diagnosis
- AI in cancer detection
- Ear Surgery and Otitis Media
- Thyroid Disorders and Treatments
University of Southern Denmark
2012-2025
Odense University Hospital
2016-2025
Centre for Cosmology and Particle Physics Phenomenology
2020
Kongsberg Innovasjon (Norway)
2019
Danish Breast Cancer Cooperative Group
2018
North Denmark Region
2018
Rigshospitalet
2018
George Institute for Global Health
2018
Onkologikoa
2011-2012
Gentofte Hospital
1973-1974
During the past decade planning of adjuvant radiotherapy (RT) early breast cancer has changed from two-dimensional (2D) to 3D conformal techniques. In computerised tomography (CT) scan both targets for RT and organs at risk (OARs) are visualised, enabling an increased focus on target dose coverage homogeneity with only minimal OARs. To ensure uniform in national prospective trials Danish Breast Cancer Cooperative Group (DBCG), a consensus delineation clinical volumes (CTVs) OARs was...
Purpose Incidental cardiac irradiation can cause injury, but little is known about the effect of radiation on specific segments. Methods For 456 women who received breast cancer radiotherapy between 1958 and 2001 then later experienced a major coronary event, information was obtained regimen they location their injury. 414 women, all with documented left ventricular (LV) doses to five LV segments were estimated. 133 artery disease ≥ 70% stenosis, six each segment, numbers left-sided...
Background and purposeThe risk of heart disease subsequent to breast cancer radiotherapy was examined with particular focus on women receiving anthracycline-containing chemotherapy.Material methodsWomen diagnosed early-stage in Denmark, 1977–2005, were identified from the register Danish Breast Cancer Cooperative Group, as information cancer-directed treatment. Information sought National Patient Cause Death Registries. Incidence rate ratios estimated comparing left-sided right-sided (IRR,...
On the basis of low risk local recurrence in elderly patients with breast cancer after conservative surgery followed by whole irradiation (WBI), Danish Breast Cancer Group initiated noninferiority external-beam partial (PBI) trial (ClinicalTrials.gov identifier: NCT00892814). We hypothesized that PBI was noninferior to WBI regarding induration.Patients operated conservation for relatively low-risk were randomly assigned versus PBI, and all had 40 Gy/15 fractions. The primary end point 3-year...
The thyroid gland is an organ at risk in breast cancer survivors who receive radiation therapy to the supraclavicular lymph nodes. We investigated effect of dose on incidence hypothyroidism early-stage patients treated with CT-guided therapy. recruited women aged ≤75 years diagnosed from March 2016 through August 2017 Odense University Hospital, Denmark. Thyroid function was measured blood samples drawn baseline, 6, 12, and 18 months. delineated using CT scans estimate volume thyroid....
Background and purposePartial breast irradiation (PBI) has been the Danish Breast Cancer Group (DBCG) standard for selected cancer patients since 2016 based on early results from DBCG PBI trial. During trial accrual, respiratory-gated radiotherapy was introduced in Denmark. This study aims to investigate effect of respiratory-gating mean heart dose (MHD).Patients methodsFrom 2009 included 230 with left-sided receiving external beam PBI, 40 Gy/15 fractions/3 weeks. Localization tumor bed...
Previously, many radiotherapy (RT) trials were based on a few selected dose measures. Many research questions, however, rely access to the complete information. To support such access, national RT plan database was created. The system focuses data security, ease of use, and re-use data. This article reports development structure, functionality experience this database.A DICOM-RT standard, DcmCollab, implemented with direct connections all Danish centres. Data is segregated into any number...
Purpose: The potential benefits from respiratory gating (RG) compared to free-breathing (FB) regarding target coverage and dose organs at risk for breast cancer patients receiving post-operative radiotherapy (RT) in the DBCG HYPO multicentre trial are reported.Material methods: Patients included were randomized between 50 Gy 25 fractions (normofractionated) versus 40 15 (hypofractionated). A tangential forward field-in-field planning technique was used cover clinical volume (CTV) with intent...
Adjuvant radiotherapy of internal mammary nodes (IMN) improves survival in high-risk early breast cancer patients but inevitably leads to more dose heart and lung. Target coverage is often compromised meet heart/lung constraints. We estimate lung when target not consecutive patients. These estimates are used guide the choice selection criteria for randomised Danish Breast Cancer Group (DBCG) Proton Trial.
Large Digital Imaging and Communications in Medicine (DICOM) datasets are key to support research the development of machine learning technology radiotherapy (RT). However, tools for multi-centre data collection, curation standardisation not readily available. Automated batch DICOM export solutions were demonstrated a multicentre setup. A Python solution, Collaborative analysis RT (CORDIAL-RT) was developed curation, standardisation, collected data. The setup DBCG RT-Nation study, where 86%...
Delineation accuracy of the gross tumor volume (GTV) in radiotherapy planning for head and neck (H&N) cancer is affected by computed tomography (CT) artifacts from metal implants which obscure identification as well organs at risk (OAR). This study investigates impact artifact reduction (MAR) H&N patients terms delineation consistency dose calculation precision radiation treatment planning.Tumor OAR delineations were evaluated CT scans eleven oropharynx with streaking region preceding...
Background and purposeShared decision making (SDM) is a patient engaging process advocated especially for preference-sensitive decisions, such as adjuvant treatment after breast cancer. An increasing call engagement in highlights the need systematic SDM approach. The objective of this trial was to investigate whether Decision Helper (DH), an in-consultation aid, increases decisions regarding whole irradiation.Material methodsOncologists at four radiotherapy units were randomized practice...