A5061022644- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- COVID-19 and healthcare impacts
- Head and Neck Cancer Studies
- Medical Imaging Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer survivorship and care
- Lung Cancer Research Studies
- SARS-CoV-2 and COVID-19 Research
- Frailty in Older Adults
- COVID-19 Clinical Research Studies
- Nutrition and Health in Aging
- Cardiac tumors and thrombi
- Venous Thromboembolism Diagnosis and Management
- Neuroendocrine Tumor Research Advances
- Management of metastatic bone disease
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Radiation Therapy and Dosimetry
- Inflammatory Biomarkers in Disease Prognosis
- Occupational and environmental lung diseases
- Telemedicine and Telehealth Implementation
- Endometrial and Cervical Cancer Treatments
- SARS-CoV-2 detection and testing
Odense University Hospital
2016-2025
University of Southern Denmark
2016-2025
Aarhus University Hospital
2024
Kongsberg Innovasjon (Norway)
2016-2019
Fondazione Roma
2018
Saint Luke's Hospital
2015
Stereotactic body radiation therapy of thoracic tumors close to the central airways implies risk severe toxicity. We report a prospective multicenter phase 2 trial for located less than or equal 1 cm from proximal bronchial tree with primary end point local control and secondary toxicity.Stereotactic 7 Gy × 8 was prescribed 67% isodose encompassing planning target volume. The patients were stratified group A (tumors ≤ main bronchi trachea) B (all other tumors). Risk factors treatment-related...
<h2>ABSTRACT</h2><h3>Introduction</h3> Stereotactic body radiation therapy (SBRT) for tumors near the central airways implies high-grade toxic effects, as concluded from HILUS-trial. However, small sample size and relatively few events limited statistical power of study. We therefore pooled data prospective HILUS-trial with retrospective patients in Nordic countries treated outside study to evaluate toxicity risk factors effects. <h3>Material Methods</h3> All were 56 Gy 8 fractions. Tumors...
Background The COVID-19 pandemic is an international public health crisis. risk of getting infection with might impact the emotional well-being in patients cancer. aim this study was to investigate quality life (QoL) for cancer during pandemic.
Introduction. Stereotactic body radiation therapy (SBRT) for early stage non-small cell lung cancer (NSCLC) is now an accepted and patient friendly treatment, but still controversy exists about its comparability to conventional (RT). The purpose of this single-institutional report describe survival outcome medically inoperable patients with NSCLC treated SBRT compared high dose RT. Material methods. From August 2005 June 2012, 100 were at Odense University Hospital. thoracic RT consisted 3...
Centrally located early-stage non-small cell lung cancer (ES NSCLC) with tumors close to the bronchi is potentially curable stereotactic body radiation therapy (SBRT). To evaluate clinical benefit of treatment, both risk high-grade toxicity as well treatment efficacy need be assessed. From expanded HILUS cohorts, 72 patients T1-T3N0M0 NSCLC were included in current analysis. All had been treated SBRT 8 fractions 56 Gy for a tumor within 2 cm from tracheobronchial tree. Primary endpoint was...
During the COVID-19 pandemic, high-risk patient groups might have practiced social distancing and sheltering, hospitals may changed or postponed treatments examinations. We aimed to explore health-related quality of life (QoL) in patients with haematological diseases during early phase pandemic their acceptability using telehealth.We performed a cross-sectional survey among at Department Haematology, Odense University Hospital, Denmark. Eligible participants were receiving either active...
Irradiation of the heart in thoracic cancers raises toxicity concerns. For accurate dose estimation, automated and substructure segmentation is potentially useful. In this study, a hybrid automatic developed. The accuracy delineation predictions were evaluated, testing method's potential within studies. method delineated heart, four chambers, three large vessels, coronary arteries. consisted nnU-net partly atlas- model-based substructures. training atlas was based on lung cancer patients...
When discussing treatment options and future care, it is important to understand the expectations of patients family caregivers related palliative chemotherapy identify patterns in patients' quality life. The study aims were evaluate differences life between with thoracic cancer (non-small-cell lung cancer, small-cell mesothelioma) who < 70 ≥ years age receiving assess caregivers' expectations.A prospective longitudinal included outpatient at a university hospital Denmark their caregivers....
Background: Patients with small cell lung cancer (SCLC) poor performance status (PS) especially in the elderly may not benefit from chemotherapy. The aim of this study was to compare survival treated patients PS 3-4 untreated patients.Material and methods: We reviewed medical records pathology data for 448 diagnosed carcinoma 2010 2015 selected all review.Results: A total 87 fulfilled inclusion criteria. Of these, 53 (61%) received chemotherapy (CT), while 34 (39%) did not. median overall...
For decades many patients with small cell lung cancer (SCLC) have been offered prophylactic cranial irradiation (PCI) to prevent brain metastases (BM). However, the role of PCI is debated in modern era increased magnetic resonance imaging (MRI) availability. BM SCLC may respond chemotherapy, and if a negative MRI used decision use treatment strategy, timing be crucial when evaluating effect PCI. This retrospective study investigates impact outcomes staged prior chemotherapy.This included 245...
Introduction: Stereotactic radiotherapy (SBRT) is the treatment of choice for inoperable early stage non-small cell lung cancer (NSCLC). We report analyses influence age on survival after SBRT. Methods and material: From 2005 to 2017, 544 previously un-irradiated patients with NSCLC had The data were analyzed in four groups: A: -69 (176 pts), B: 70-74 (115 C: 75-79 (131 pts) D: 80 years or older (122 pts). Two SBRT dose regimes used: 45 Gy/3F (N = 103) 66 441). Results: All a follow up (time...
The Geriatric 8 (G-8) is a known predictor of overall survival (OS) in older cancer patients, but mainly based on nutritional aspects. This study aimed to assess if the G-8 combined with hand-grip strength test (HGST) patients NSCLC treated stereotactic body radiotherapy can predict long-term OS better than alone. A total 46 SBRT-treated stage T1-T2N0M0 were included. Patients divided into three groups: fit (normal and HGST), vulnerable (abnormal or frail HGST). Statistically significant...
The general population is aging, which expectedly will lead to a future increase in older patients with cancer. This review summarises the recent advances radiotherapy. Technological have led radiotherapy be an efficient and well-tolerated treatment option patient Studies show no difference toxicity disease control rates compared ones younger MR-guided radiotherapy, proton therapy, integration of artificial intelligence planning represent latest field hold potential further improve
Background: Little information on the natural history of patients with localized NSCLC is available since many studies covering subject lack pathological confirmation, staging procedures and comorbidity. No randomized have compared SBRT no treatment for NSCLC. The purpose this study was to evaluate whether has influence overall survival investigate effect baseline ventilatory lung function survival.Material methods: From 2007 2013, 136 treated at Odense University Hospital were prospectively...
Patients with lung cancer face a substantially increased risk of thromboembolic disease. localized non-small cell (NSCLC) who are unfit for surgery due to age or comorbidity have additional thrombotic factors. Thus, we aimed investigate markers primary and secondary hemostasis, since this could assist in treatment decisions. We included 105 patients NSCLC. Ex vivo thrombin generation was determined by calibrated automated thrombogram measurement thrombin-antithrombin complex (TAT) levels...