A5024356923- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Blood groups and transfusion
- Platelet Disorders and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- COVID-19 and healthcare impacts
- Multiple Myeloma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Blood properties and coagulation
- Blood disorders and treatments
- Cancer survivorship and care
- Renal Diseases and Glomerulopathies
- Autoimmune Bullous Skin Diseases
- COVID-19 Clinical Research Studies
- Eosinophilic Disorders and Syndromes
- Childhood Cancer Survivors' Quality of Life
- Musculoskeletal pain and rehabilitation
- Advanced Breast Cancer Therapies
- CNS Lymphoma Diagnosis and Treatment
- Complement system in diseases
Odense University Hospital
2016-2025
University of Southern Denmark
2009-2025
Quality of Life Research Center
2018-2024
Copenhagen University Hospital
2018-2023
Ludwig-Maximilians-Universität München
2023
Hospital Universitario Puerta de Hierro Majadahonda
2023
Ministry of Health
2023
Wroclaw Medical University
2023
Agostino Gemelli University Polyclinic
2023
Ministry of Health
2023
Randomized trials of venetoclax plus anti-CD20 antibodies as first-line treatment in fit patients (i.e., those with a low burden coexisting conditions) advanced chronic lymphocytic leukemia (CLL) have been lacking. Download PDF the Research Summary. In phase 3, open-label trial, we randomly assigned, 1:1:1:1 ratio, CLL who did not TP53 aberrations to receive six cycles chemoimmunotherapy (fludarabine–cyclophosphamide–rituximab or bendamustine–rituximab) 12 venetoclax–rituximab,...
In the primary analysis report of GAIA/CLL13 trial, we found that venetoclax-obinutuzumab and venetoclax-obinutuzumab-ibrutinib improved undetectable measurable residual disease (MRD) rates progression-free survival compared with chemoimmunotherapy in patients previously untreated chronic lymphocytic leukaemia. However, to our knowledge, no data on direct comparisons different venetoclax-based combinations are available.
Questionnaire-based zygosity assessment in twins has generally been found to be valid. In this report we evaluate sex- and age-differences the validity of such questionnairebased classification when using four questions that have basis The Danish Twin Registry for half a century. Three hundred forty-two male 531 female twin pairs were diagnosed genetic markers results compared with original questionnaire based classification. We significant differences accuracy diagnosis stratifying data sex...
Abstract Physical functioning late in life has been shown to be affected by genetic factors. Only a few variants have suggested associated with physical functioning, and this only selected populations (e.g., young healthy males elite athletes). Declining is major problem terms of prevalence, morbidity, functional limitations, quality life. It therefore interest find phenotype reflecting which relatively high heritability can measured large samples. Hand grip strength known muscular other...
Summary The impact of first‐line treatment with the anti‐ CD 20 chimeric monoclonal antibody rituximab in patients warm‐antibody reactive autoimmune haemolytic anaemia ( WAIHA ) is unknown. We report first randomized study 64 newly diagnosed who received prednisolone and combined N = 32) or monotherapy 32). After 12 months, a satisfactory response was observed 75% treated but significantly smaller proportion (36%) those given alone P 0·003). Furthermore, relapse‐free survival better after...
Summary Studies have reported a 1·3‐ to 2·2‐fold higher mortality rate among patients with primary immune thrombocytopenia ( ITP ) compared the general population. However, long‐term estimates as well cause‐specific data are sparse. In our population‐based cohort of adult newly diagnosed and up 37 years follow‐up, 5‐year, 10‐year 20‐year was 22%, 34% 49%, respectively. The in consistently than population yielding an adjusted hazard ratio HR 1·5 [95% confidence interval CI ): 1·2–1·8]. s due...
Abstract Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due age, disease, and treatment-related immunosuppression. We aimed assess risk factors of outcome elucidate the impact CLL-directed treatments on course COVID-19. conducted a retrospective, international study, collectively including 941 patients CLL confirmed Data from beginning pandemic until March 16, 2021, were collected 91 centers. The case fatality rate (CFR),...
It is well established that the male sex associated with increased risk for, as poorer survival of, most cancers. A similar pattern has been described in lymphomas but not yet comprehensively assessed. In this nationwide population-based cohort study, we used Swedish Lymphoma Register to investigate differences lymphoma subtype incidence and excess mortality adults (age 18-99) diagnosed 2000-2019. Male-to-female rate ratios (IRRs) (EMRs) adjusted for age calendar year were predicted using...
The aim of the present twin study was to estimate relative importance genetic and environmental factors in variation self-reported reduced hearing among old oldest old.Self-reported abilities older twins assessed at intake interview a population-based longitudinal survey.Denmark.Twins age 75 identified Danish Twin Registry 1995. An conducted with 77% 3,099 individuals population. In 1997 1999, follow-up contact survivors made an additional 2,778 twins, 70-76, were included study.Reduced by...
<b><i>Objective:</i></b> To assess the relative contribution of genetic and environmental factors for etiology essential tremor (ET) to explore effect different diagnostic criteria. <b><i>Methods:</i></b> A total 2,448 twins Danish twin registry aged 70 years or more were screened ET by an interview Archimedes spiral test. All pairs (n = 162) with a positive screening test at least one recontacted 218 individuals (109 pairs) interviewed examined movement disorder specialist. The consensus...
We aimed to assess the relative contribution of genes and environment in aetiology Dupuytren's disease by studying Danish twins born between 1870 2000. Twins with a diagnosis (n = 365) subgroup who also had an operation 259) after 1977 were identified through linkage nationwide hospital registry among 30,330 monozygotic same-sexed dizygotic twin pairs. Since share all their on average half genetic material, greater phenotypic similarity is expected than if component involved. The number...
In patients with systemic mastocytosis (SM), several aspects of morbidity remain poorly understood. We assessed the risk solid cancers, cardiovascular disease, anaphylaxis, osteoporosis, and fractures in SM patients. Using Danish medical registries, we conducted a nationwide population-based cohort study including 687 adult (≥15 years) diagnosed during 1997-2012. A comparison 68,700 subjects from general population who were alive without at given subject's diagnosis age- gender-matched....
Abstract Patients with Evans syndrome have both immune thrombocytopenia and autoimmune hemolytic anemia, but little is known about the epidemiology of this rare syndrome. can be primary or secondary. This nationwide retrospective study linked health registries to identify 242 patients in Denmark 1977‐2017. For comparison, we identified three age‐matched sex‐matched cohorts only a general population cohort. The cohort had mean age 58.5 years at diagnosis, 51.2% were women, 27.3% classified as...