A5101981447- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Radiation Therapy and Dosimetry
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced X-ray and CT Imaging
- Chronic Lymphocytic Leukemia Research
- Head and Neck Cancer Studies
- Gastrointestinal Tumor Research and Treatment
- Radiopharmaceutical Chemistry and Applications
- Management of metastatic bone disease
- Lymphoma Diagnosis and Treatment
- Ultrasound and Hyperthermia Applications
- Medical Image Segmentation Techniques
- 3D Printing in Biomedical Research
- Brain Metastases and Treatment
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Vector-Borne Animal Diseases
- Nanoparticle-Based Drug Delivery
- Trauma Management and Diagnosis
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
Odense University Hospital
2016-2025
University of Copenhagen
2014-2023
University of Southern Denmark
2011-2013
Stereotactic body radiation therapy of thoracic tumors close to the central airways implies risk severe toxicity. We report a prospective multicenter phase 2 trial for located less than or equal 1 cm from proximal bronchial tree with primary end point local control and secondary toxicity.Stereotactic 7 Gy × 8 was prescribed 67% isodose encompassing planning target volume. The patients were stratified group A (tumors ≤ main bronchi trachea) B (all other tumors). Risk factors treatment-related...
<h2>ABSTRACT</h2><h3>Introduction</h3> Stereotactic body radiation therapy (SBRT) for tumors near the central airways implies high-grade toxic effects, as concluded from HILUS-trial. However, small sample size and relatively few events limited statistical power of study. We therefore pooled data prospective HILUS-trial with retrospective patients in Nordic countries treated outside study to evaluate toxicity risk factors effects. <h3>Material Methods</h3> All were 56 Gy 8 fractions. Tumors...
In a prospective study 99 consecutive patients with operative indication due to severe aortic stenosis (AS) were put on surgical waiting list. The waiting-time valve replacement (AVR) averaged 6.3 months (0.5-19 months). There 58 men and 41 women mean age of 61 years (21-82 years). divided into three groups: group I (n = 81) an uneventful stay the list (including one patient who declined AVR offer); II 11) significant worsening prognostic index; III 7) died during waiting-time. waiting-list...
Abstract Ibrutinib has now been approved for treatment of chronic lymphocytic leukemia (CLL) in both front‐line setting and as later‐line treatment. However, knowledge about the outcomes adverse events (AE) among patients at a population‐based level is still limited. Objectives To report AEs cohort treated with ibrutinib outside clinical trials. Methods We conducted multicenter, retrospective study including all CLL ibrutinib. Results In total, 205 were included whom 39 (19%)...
Centrally located early-stage non-small cell lung cancer (ES NSCLC) with tumors close to the bronchi is potentially curable stereotactic body radiation therapy (SBRT). To evaluate clinical benefit of treatment, both risk high-grade toxicity as well treatment efficacy need be assessed. From expanded HILUS cohorts, 72 patients T1-T3N0M0 NSCLC were included in current analysis. All had been treated SBRT 8 fractions 56 Gy for a tumor within 2 cm from tracheobronchial tree. Primary endpoint was...
LBA8069 Background: The survival and loco-regional control for patients (pts) with locally advanced non-small cell lung cancer (LA_NSCLC) treated radiotherapy (RT) are dismal despite adjuvant Durvalumab. However, there have been concerns about dose escalation these pts since the unexpected result of dose-escalation trial RTOG0617. A novel approach is therefore warranted to escalate tumor. possible use principle from stereotactic body (SBRT) inhomogeneous distribution. SBRT has demonstrated...
Purpose: To investigate differences in calculated doses and normal tissue complication probability (NTCP) values between different dose algorithms. Methods: Six algorithms from four treatment planning systems were investigated: Eclipse AAA, Oncentra MasterPlan Collapsed Cone Pencil Beam, Pinnacle XiO Multigrid Superposition, Fast Fourier Transform Convolution. Twenty NSCLC patients treated the period 2001–2006 at same accelerator included used for treatments modeled systems. The plans...
Non-small cell lung cancer (NSCLC) is associated with poor survival even though patients are treated curatively intended radiotherapy. Survival affected negatively by lack of loco-regional tumour control, but also influenced comorbidity caused age and smoking, occurrence distant metastasis. It challenging to evaluate control after definitive radiotherapy for NSCLC since it difficult distinguish between radiation-induced damage the tissue progression/recurrence. In addition may be useful...
Background. Higher doses to NSCLC tumours are required increase the low control rates obtained with conventional dose prescriptions. This study presents concept of inhomogeneous distributions as a general way local probability, not only for isolated lung but also patients involved lymph nodes. Material and methods. Highly modulated IMRT plans homogeneous prescribed 66Gy/33F were created 20 patients, staged T1b-T4 N0-N3, using standard PTV coverage 95–107%. For each patient, an distribution...
SBRT of central lung tumours implies significant risk toxicity. We are initiating two phase II trials prescribing 56 Gy/eight fractions to PTV, allowing for dose escalation GTV. prioritize organs at (OAR) constraints over target coverage, making the treatment plans very sensitive OAR delineation variations. The aim this study is quantify dosimetric impact contouring variations and provide a thorough description pre-trial quality assurance be used in upcoming consistent clinical...
For chronic lymphocytic leukaemia (CLL), targeted drugs have become the standard of care, in particular for second-line treatment. In this study, overall survival (OS), treatment-free (TFS) and adverse events (AE) were registered retrospectively a Danish population-based cohort upon treatment CLL. Data collected from medical records National CLL register. 286 patients receiving treatment, three-year TFS was higher (ibrutinib/venetoclax/idelalisib) [63%, 95% confidence interval (CI) 50%-76%]...
For decades many patients with small cell lung cancer (SCLC) have been offered prophylactic cranial irradiation (PCI) to prevent brain metastases (BM). However, the role of PCI is debated in modern era increased magnetic resonance imaging (MRI) availability. BM SCLC may respond chemotherapy, and if a negative MRI used decision use treatment strategy, timing be crucial when evaluating effect PCI. This retrospective study investigates impact outcomes staged prior chemotherapy.This included 245...
The McStas neutron ray-tracing software package is a versatile tool for building accurate simulators of scattering instruments at reactors, short- and long-pulsed spallation sources such as the European Spallation Source. extensively used design optimization instruments, virtual experiments, data analysis user training. was founded scientific, open-source collaborative code in 1997.
The aim is to quantify and analyse tumour motion during a course of treatment for lung SBRT patients.Peak-to-peak 483 tumours in 441 patients treated with peripheral at single institution over two year period was measured on planning CT all fractions. Planning 4D-CT scans were analysed using our clinical workflow involving deformable propagation the delineated target phases. Similarly, acquisition 4D-CBCT data followed based XVI 5.0 available Elekta linacs. Differences correlations...
Haemophagocytic lymphohistiocytosis (HLH) is a syndrome with an abnormal activation of the immune system and associated high mortality even treatment. We present case woman in her mid-50s who developed HLH triggered by miliary tuberculosis (TB) while receiving tumour necrosis factor alpha inhibitor. The patient was admitted fever respiratory pain. Her condition deteriorated despite empirical Diagnosis established based on clinical presentation, H-score HLH-04 criteria. Concurrently, TB...