A5069471024- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Lung Cancer Treatments and Mutations
- Medical Imaging Techniques and Applications
- Management of metastatic bone disease
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Spinal Fractures and Fixation Techniques
- Radiation Therapy and Dosimetry
- Spine and Intervertebral Disc Pathology
- Medical Imaging and Pathology Studies
- Occupational and environmental lung diseases
- Pleural and Pulmonary Diseases
- Gastric Cancer Management and Outcomes
- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Mathematical Biology Tumor Growth
- Prostate Cancer Treatment and Research
- Head and Neck Cancer Studies
- COVID-19 and healthcare impacts
- Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Effects of Radiation Exposure
University of Antwerp
2020-2025
Iridium Kankernetwerk
2018-2025
GZA Ziekenhuizen Campus Sint-Augustinus
2020-2022
KU Leuven
2014-2018
Hasselt University
2016-2017
Centre Léon Bérard
2016
University Medical Center Freiburg
2016
Radiation Oncology Associates
2013
Hôtel-Dieu de Lyon
2006
Stereotactic body radiation therapy of thoracic tumors close to the central airways implies risk severe toxicity. We report a prospective multicenter phase 2 trial for located less than or equal 1 cm from proximal bronchial tree with primary end point local control and secondary toxicity.Stereotactic 7 Gy × 8 was prescribed 67% isodose encompassing planning target volume. The patients were stratified group A (tumors ≤ main bronchi trachea) B (all other tumors). Risk factors treatment-related...
<h2>ABSTRACT</h2><h3>Introduction</h3> Stereotactic body radiation therapy (SBRT) for tumors near the central airways implies high-grade toxic effects, as concluded from HILUS-trial. However, small sample size and relatively few events limited statistical power of study. We therefore pooled data prospective HILUS-trial with retrospective patients in Nordic countries treated outside study to evaluate toxicity risk factors effects. <h3>Material Methods</h3> All were 56 Gy 8 fractions. Tumors...
Abstract Background The purpose of this randomised study was to determine whether dose‐intensified stereotactic body radiotherapy (SBRT) for painful vertebral metastases results in increased rates pain improvement compared with conventional external beam (cEBRT) (control) 6 months after treatment. Methods This randomized, controlled phase 3 trial conducted between November 2016 and January 2023, when it stopped early. Patients were eligible if they aged 18 years or older; had one two...
Background: Making informed decisions about clinical trial participation can be overwhelming for patients due to the complexity of information, potential risks and benefits, emotional burden a recent diagnosis. Patient decision aids (PDAs) simplify this process by providing clear information on treatment options, empowering actively participate in shared decision-making (SDM) with their doctors. While PDAs have shown promise various healthcare contexts, use trials, particularly form...
Centrally located early-stage non-small cell lung cancer (ES NSCLC) with tumors close to the bronchi is potentially curable stereotactic body radiation therapy (SBRT). To evaluate clinical benefit of treatment, both risk high-grade toxicity as well treatment efficacy need be assessed. From expanded HILUS cohorts, 72 patients T1-T3N0M0 NSCLC were included in current analysis. All had been treated SBRT 8 fractions 56 Gy for a tumor within 2 cm from tracheobronchial tree. Primary endpoint was...
Abstract Background About 50% of non-small cell lung cancer (NSCLC) patients have metastatic disease at initial diagnosis, which limits their treatment options and, consequently, the 5-year survival rate (15%). Immune checkpoint inhibitors (ICI), either alone or in combination with chemotherapy, become standard care (SOC) for most good performance status patients. However, will not obtain long-term benefit and new strategies are therefore needed. We previously demonstrated clinical safety...
Early in March 2020, the SARS-CoV-2 (COVID-19) pandemic struck Belgium [1].Our large radiation oncology department took immediate precautionary measures to prevent COVID-19-induced saturation of health resources that may lead delays and possibly inability provide therapy our patients.As part emergency adjustments, we implemented an ultrahypofractionation scheme 26 Gy five consecutive fractions, based on FAST-Forward trial, for postoperative breast cancer patients [2,3].Prior COVID-19...
Postoperative ultrahypofractionated radiation therapy (UHFRT) in 5 fractions (fx) for breast cancer patients is as effective and safe conventionally hypofractionated RT (HFRT) 15 fx, liberating time higher-level daily online Image-Guided Radiation Therapy (IGRT) corrections. In this retrospective study, treatment uncertainties occurring treated with 5fx (5fx-group) were evaluated using electronic portal imaging device (EPID)-based in-vivo dosimetry (EIVD) compared the results from HFRT...
This study aims to analyze the contribution and application of forced oscillation technique (FOT) devices in lung cancer assessment. Two corresponding methods can be feasible distinguish among various degrees tissue heterogeneity.The outcome respiratory impedance Zrs (in terms resistance Rrs reactance Xrs) is calculated for FOT interpreted physiological by being fitted with a fractional-order mathematical model (FOIM). The non-parametric data obtained from measured signals pressure flow...
Bone metastases represent an important source of morbidity in cancer patients, mostly due to severe pain. Radiotherapy is established symptomatic treatment for painful bone metastases, however, when conventional techniques are used, the effectiveness moderate. Stereotactic body radiotherapy (SBRT), delivering very high doses a limited number fractions highly conformal manner, could potentially be more effective and less toxic. This phase III, randomized-controlled, single-blind, multicenter...
Abstract Background In radical radiochemotherapy (RCT) of inoperable non-small-cell lung cancer (NSCLC) typical prognostic factors include T- and N-stage, while there are still conflicting data on the relevance gross tumor volume (GTV) particularly its changes during RCT. The NCT03055715 study Young DEGRO working group German Society Radiation Oncology (DEGRO) evaluated impact GTV Methods A total 21 university centers for radiation oncology from five different European countries (Germany,...
Individual curves for tumor growth can be expressed as mathematical models. Herein we exploited a pharmacokinetic-pharmacodynamic (PKPD) model to accurately predict the lung when using data from clinical study. Our analysis included 19 patients with non-small cell cancer treated specific hypofractionated regimens, defined stereotactic body radiation therapy (SBRT). The results exhibited utility of PKPD testing hypotheses against data. fitted observed progression behavior tumors by measuring...
Increasing evidence suggests that patients with a limited number of metastases benefit from SABR to all lesions. However, the optimal dose and fractionation remain unknown. This is particularly true for bone lymph node metastases. Therefore, prospective, single-center, dose-escalation trial was initiated.Dose-Escalation STereotactic ablative body RadiOtherapY non-spine (DESTROY) an open-label phase 1 evaluating nonspine lesions in up 3 Patients European Cooperative Oncology Group performance...