A5034353270- Advances in Oncology and Radiotherapy
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer Cells and Metastasis
- Radiation Dose and Imaging
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Management of metastatic bone disease
- Economic and Financial Impacts of Cancer
- Innovations in Medical Education
- Breast Cancer Treatment Studies
- Multiple Sclerosis Research Studies
- Medical Imaging Techniques and Applications
- Colorectal Cancer Surgical Treatments
- Prostate Cancer Treatment and Research
- Lung Cancer Research Studies
- Surgical Simulation and Training
- Glioma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Interprofessional Education and Collaboration
- Polyomavirus and related diseases
- Lymphatic System and Diseases
Jena University Hospital
2017-2025
Klinik und Poliklinik für Strahlentherapie und Radioonkologie
2021-2025
Friedrich Schiller University Jena
2021-2025
Comprehensive Cancer Center Mainfranken
2024
Labor Pachmann
2024
Stiftung Juliusspital
2021
Icahn School of Medicine at Mount Sinai
2016
Columbia University
2016
Caritas-Krankenhaus Bad Mergentheim
2009-2015
Temple College
2010
<h3>Context</h3>Disruption of frontal-subcortical and limbic networks is hypothesized to have a key role in late-life depression (LLD) can be examined using magnetic resonance imaging (MRI) techniques. Gray matter T1-weighted MRI, white T2-weighted MRI diffusion tensor imaging, functional connectivity resting-state MRI. Although independent studies supported gray abnormalities frontosubcortical increased the default-mode network depression, no study has concurrently matter,...
Prostate cancer is a leading cause of cancer-related mortality in men, with radiotherapy (RT) playing pivotal role treatment. However, reliable biomarkers for assessing relapse risk following RT remain scarce. This study aimed to evaluate circulating epithelial tumor cells (CETC/CTC) as potential prostate patients undergoing RT. Peripheral blood samples were collected from 52 patients, and CETC/CTC detected using the EpCAM surface marker. Patients received definitive, adjuvant, or salvage...
Abstract Background Progression-free (PFS) and overall survival (OS) in UICC stage III non-small cell lung cancer (NSCLC) after definitive concurrent chemoradiotherapy (CRT) can be increased with consolidating immunotherapy. Recent studies have shown a strong predictive value of gross tumor volume (GTV) changes during CRT on OS. The TORCH trial investigated the prognostic impact GTV as predictor for response to Methods This retrospective non-interventional observational multicenter included...
Improving the sustainability and cost-effectiveness of healthcare systems has become increasingly relevant in times climate change, energy transition, an aging population skyrocketing social costs. The selection adequate fractionation schedule is fundamental importance field Radiation Oncology. We evaluated three internationally established schedules for definitive prostate cancer radiation therapy (RT) with respect to their ecological health-economic impacts.We analyzed data 109 patients...
Abstract Purpose Tumor boards serve as established platforms for interdisciplinary expert discussions and therapeutic recommendations tailored to individual patient characteristics. Despite their significance, medical students often lack exposure such tumor are currently not integrated into curricula. To address this, we aimed enhance future physicians' communication skills subject-specific knowledge by introducing an interactive series of five linked board seminars within the domain...
The new Medical Licensing Regulations 2025 (Ärztliche Approbationsordnung, ÄApprO) require the development of competence-oriented teaching formats. In addition, there is a great need for high-quality in field radiation oncology, which manifests itself already during medical school. For this reason, we developed simulation-based, hands-on education format to teach competency performing accelerated partial breast irradiation (APBI) with interstitial multicatheter brachytherapy early cancer....
Modern, personalized treatment concepts in oncology require an interdisciplinary and multiprofessional collaboration. In addition to its relevance patient care, collaboration is also becoming increasingly important clinical research as well medical education resident training oncology.Between November 2021 March 2022, online survey was conducted among German early career groups, represented by Young Oncologists United (YOU). The aim identify the status need for interdisciplinarity at clinic,...
Abstract Purpose Medical students’ knowledge of radiation oncology (RO) is increasing importance with a rising prevalence malignancies. However, RO teaching in medical schools heterogeneous and has not been analyzed at federal level yet. Therefore, the following survey aims to provide national overview Germany. Methods A questionnaire containing multiple-choice free-text questions covering extent topics was sent departments all university hospitals Germany answered by heads department/main...
Adjuvant radiotherapy (RT) is an integral component of a multidisciplinary treatment strategy for early-stage breast cancer. It significantly reduces the incidence loco-regional recurrence but also distant events. Distant events are due to tumor cells disseminated from primary into lymphatic fluid or blood, circulating epithelial (CETC/CTC), which can reach tissues and regrow metastases. The purpose this study determine changes in number CETC/CTC course adjuvant RT, evaluate whether they...
Abstract Progressive multifocal leukoencephalopathy (PML) is a severe infection of the CNS caused by polyomavirus JC that can occur in multiple sclerosis patients treated with natalizumab. Clinical management natalizumab-associated PML challenging not least because current imaging tools for early detection, longitudinal monitoring and differential diagnosis lesions are limited. Here we evaluate whether translocator protein (TSPO) PET be applied to monitor inflammatory activity over time...
Abstract Purpose This survey aimed to determine the perception of brachytherapy training among residents in DACH region, consisting Austria, Germany and Switzerland. Material & Methods An online questionnaire containing 22 questions related trainee demographics ( n = 5) 17) was sent two iterations 11/2019 02/2020. The following topics were evaluated: institutional support, barriers training, extent site-specific (prostate, gynaecology, breast, gastrointestinal skin), preferences for...
: There is an unmet need to identify biomarkers that directly reflect response adjuvant radiotherapy (RT). Circulating epithelial tumor cells (CETCs) represent the liquid component of solid tumors and are responsible for metastatic relapse. CETC subsets with cancer stem cell characteristics, circulating (cCSCs), play a pivotal role in cascade. Monitoring most aggressive subpopulation CETCs could aggressiveness remaining burden. limited data on detection monitoring changes cCSC numbers during...
Abstract Background In radical radiochemotherapy (RCT) of inoperable non-small-cell lung cancer (NSCLC) typical prognostic factors include T- and N-stage, while there are still conflicting data on the relevance gross tumor volume (GTV) particularly its changes during RCT. The NCT03055715 study Young DEGRO working group German Society Radiation Oncology (DEGRO) evaluated impact GTV Methods A total 21 university centers for radiation oncology from five different European countries (Germany,...
Abstract Background Stage III non-small cell lung cancer (NSCLC) represents a highly heterogeneous disease and treatment burden. Advances in imaging modality show promising results for radiotherapy planning. In this multicentric study, we evaluated the impact of PET/CT-based planning on prognosis patients with stage NSCLC. Method A retrospective observational cohort study (ARO 2017-01/NCT03055715) was conducted by young DEGRO trial group German Society Radiation Oncology (DEGRO) primary...
Abstract This paper explores the underutilized educational potential of tumor boards as a platform for medical student education. Acknowledging complexity and multidisciplinary nature boards, we propose 12 strategic interventions aimed at integrating undergraduate students into these meetings to enhance their learning experience. These strategies emphasize active engagement, critical analysis, patient interaction, reflective practice, integration digital tools, with focus on fostering an...
Abstract Objective The aim of this work is to define competencies and entrustable professional activities (EPAs) be imparted within the framework surgical neuro-oncological residency fellowship training as well education medical students. Improved specific in neuro-oncology promotes expertise, quality treatment may also contribute further development techniques protocols. Specific curricula for a neuro-oncologic have not yet been established. Methods We used consensus-building approach...
The aim of this study was to analyze the heart dose for left-sided breast cancer that can be achieved during daily practice in patients treated with multicatheter brachytherapy (MCBT) accelerated partial-breast irradiation (APBI) and deep-inspiration breath-hold (DIBH) whole-breast (WBI) using a simultaneous integrated tumor bed boost (SIB)-two different concepts which nonetheless share some patient overlap.We analyzed nominal average (Dmean) as well biologically effective (BED) equivalent...
Abstract Background and purpose Radiation oncology is an essential component of therapeutic necessitates well-trained personnel. Multicatheter brachytherapy (MCBT) one radiotherapeutic option for early-stage breast cancer treatment. However, specialized hands-on training MCBT not currently included in the curriculum residents. A recently developed workshop has demonstrated promising results enhancing knowledge practical skills. Nevertheless, these simulation-based teaching formats...
Abstract Purpose To evaluate the reviewing behaviour in German-speaking countries order to provide recommendations increase attractiveness of activity field radiation oncology. Methods In November 2019, a survey was conducted by Young DEGRO working group (jDEGRO) using online platform “eSurveyCreator”. The questionnaire consisted 29 items examining broad range factors that influence motivation and performance. Results A total 281 responses were received. Of these, 154 (55%) completed...
We recently addressed the challenges of German Health Care System (GHCS) in an era aging population and economic problems discussing funding process, hospital management ambulatory care, with a focus on cost control mechanisms quality improvement measures. Pharmaceutical issues have not been mentioned detail. It is interest that increases Social Insurance (SHI) expenditures pharmaceuticals Germany were above European average last decades. There are three main aspects to consider when it...