A5080916428- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Immune cells in cancer
- Meningioma and schwannoma management
- Lung Cancer Treatments and Mutations
- Traumatic Brain Injury and Neurovascular Disturbances
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Nanoplatforms for cancer theranostics
- ATP Synthase and ATPases Research
- Sepsis Diagnosis and Treatment
- MRI in cancer diagnosis
- Cardiac Arrest and Resuscitation
- Cancer Research and Treatments
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging and Pathology Studies
- Advanced MRI Techniques and Applications
- Neuroblastoma Research and Treatments
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
Heidelberg University
2016-2025
University Hospital Heidelberg
2016-2025
National Center for Tumor Diseases
2014-2024
Heidelberg University
2024
German Cancer Research Center
2022
Deutschen Konsortium für Translationale Krebsforschung
2022
Goethe University Frankfurt
2015-2019
Universität Ulm
2015-2019
Kiel University
2015-2019
Zimmer Biomet (Germany)
2019
To correlate histopathologic findings from biopsy specimens with their corresponding location within enhancing areas, non-enhancing areas and necrotic on contrast enhanced T1-weighted MRI scans (cT1).In 37 patients newly diagnosed glioblastoma who underwent stereotactic biopsy, we obtained a correlation of 561 1mm3 position the intraoperative cT1 image at 1.5 Tesla. Biopsy points were categorized as (CE), (NE) or (NEC) tissue samples "viable tumor cells", "blood" "necrotic (with without...
The ideal treatment strategy for low-grade gliomas (LGGs) is a controversial topic. Additionally, only smaller single-center series dealing with the concept of intraoperative magnetic resonance imaging (iMRI) have been published.To investigate determinants patient outcome and progression-free-survival (PFS) after iMRI-guided surgery LGGs in multicenter retrospective study initiated by German Study Group Intraoperative Magnetic Resonance Imaging.A consecutive assessment patients treated...
Abstract Purpose: Targeting immunosuppressive and pro-tumorigenic glioblastoma (GBM)-associated macrophages microglial cells (GAM) has great potential to improve patient outcomes. Colony-stimulating factor-1 receptor (CSF1R) emerged as a promising target for reprograming anti-inflammatory M2-like GAMs. However, treatment data on patient-derived, tumor-educated GAMs their influence the adaptive immunity are lacking. Experimental Design: CD11b+-GAMs freshly isolated from tumors were treated...
Introduction A greater extent of resection the contrast-enhancing (CE) tumour part has been associated with improved outcomes in glioblastoma. Recent results suggest that non-contrast-enhancing (NCE) might yield even better survival (supramaximal resection, SMR). Therefore, this study evaluates efficacy and safety SMR without mapping techniques high-grade glioma (HGG) patients terms survival, functional, neurological, cognitive quality life outcomes. Furthermore, it which benefit most from...
To date, standardized strategies for the treatment of recurrent glioma are lacking. Chemotherapy with alkylating agent BCNU (1,3-bis (2-chloroethyl)-1-nitroso-urea) is a therapeutic option even though its efficacy and safety, particularly risk pulmonary fibrosis, remains controversial. address these issues, we performed retrospective analysis on clinical outcome side effects BCNU-based chemotherapy in glioma.Survival data 34 mostly chemotherapy-naïve glioblastoma patients treated at 1st...
Objective Several studies have analyzed a correlation between the apparent diffusion coefficient (ADC) derived from diffusion-weighted MRI and tumor cellularity of corresponding histopathological specimens in brain tumors with inconclusive findings. Here, we compared large dataset ADC values stereotactic biopsies glioblastoma patients using new postprocessing approach including trajectory analysis automatic nuclei counting. Materials Methods Thirty-seven newly diagnosed glioblastomas were...
Meningiomas are frequent central nervous system tumors. Although most meningiomas benign (WHO grade I) and curable by surgery, WHO II III tumors remain therapeutically challenging due to recurrence. Interestingly, relapse also occurs in some I meningiomas. Hence, we investigated the transcriptional features defining aggressive (recurrent, malignantly progressing or III) 144 cases. were categorized into non-recurrent (NR), recurrent (R), undergoing malignant progression (M) addition their...
Abstract BACKGROUND In diffuse WHO grade II gliomas (LGG), the extent of resection (EOR) required to achieve significant survival benefits remains elusive. OBJECTIVE To evaluate association residual volume (RV) and EOR with progression-free (PFS) or overall (OS) in LGG a retrospective, multicenter series by German study group intraoperative MRI (GeSGIM). METHODS Consecutive cases were retrospectively assessed from 5 centers. Tumors volumetrically quantified before after surgery, clinical...
Surgery for recurrent glioma provides cytoreduction and tissue molecularly informed treatment. With mostly heavily pretreated patients involved, it is unclear whether the benefits of repeat surgery outweigh its potential risks.
Malignant gliomas impose a significant symptomatic burden on patients and their families. Current guidelines recommend palliative care for with advanced tumors within eight weeks of diagnosis, emphasizing early integration malignant glioma cases. However, the utilization rate these in Germany remains unquantified. This study investigates proportion who either died hospital or were transferred to hospice from 2019 2022, prevalence in-patient specialized interventions.
Physical activity is a potent way to impede vascular ageing. However, patients who suffer from peripheral artery disease (PAD) are often unable exercise adequately. For those patients, we have developed individual shear rate therapy (ISRT), which an adaptation of external counterpulsation and enhances endovascular fluid stress increase collateral growth (arteriogenesis). To evaluate the effects physical ISRT on telomere biology blood mononuclear cells (PBMCs), conducted two clinical...
OBJECTIVE In this analysis, the authors sought to identify variables triggering an additional resection (AR) and determining residual intraoperative tumor volume in 1.5-T MRI (iMRI)-guided glioma resections. METHODS A consecutive case series of 224 supratentorial resections (WHO Grades I–IV) from a prospective iMRI registry (inclusion dates January 2011–April 2013) was examined with univariate multiple regression models including volumetric data, tumor-related, surgeon-related factors. The...
The spatial relationship of glioblastoma (GBM) to the subventricular zone (SVZ) is associated with inferior patient survival. However, underlying molecular phenotype largely unknown. We interrogated an SVZ-dependent transcriptome and potential location-specific prognostic markers.mRNA microarray data a discovery set (n = 36 GBMs) were analyzed for gene expression process networks using MetaCore™ workflow. Differential was confirmed by qPCR in validation 142 IDH1 wild-type GBMs that also used...
Recent studies suggest that glioblastomas (GBMs) contacting the subventricular zone (SVZ) as main adult neurogenic niche confer a dismal prognosis but disregard unique molecular and prognostic phenotype associated with isocitrate dehydrogenase 1 (IDH1) mutations. We therefore examined location-dependent factors, growth, recurrence patterns in consecutive cohort of 285 IDH1-wildtype GBMs. Based on pre-operative contrast-enhanced MRI, patients were allotted to four groups (SVZ+; I, II) without...
Intraventricular meningiomas (IVMs) account for less than 5% of all intracranial meningiomas; hence their molecular phenotype remains unknown. In this study, we were interested whether genetic alterations in IVMs differ from other locations and analyzed our institutional series with respect to clinical characteristics. A total 25 patients surgical removal an IVM at department between 1986 2018 identified database. Median progression-free survival (PFS) was 79 months (range 2–319 months) PFS...
Background and Purpose After surgical resection of brain metastases (BM), radiotherapy (RT) is indicated. Postoperative stereotactic radiosurgery (SRS) reduces the risk local progression neurocognitive decline compared to whole (WBRT). Aside from optimal dose fractionation, little known about combination systemic therapy postoperative fractionated (fSRT), especially regarding tumour control toxicity. Methods In this study, 105 patients receiving fSRT with 35 Gy in 7 fractions performed...
Technical advances and the increasing role of interdisciplinary decision-making may warrant formal definitions expertise in surgical neuro-oncology.
Abstract Purpose: Successful immunotherapies for IDHmut gliomas require better knowledge of T-cell target antigens. Here, we elucidated their antigen repertoire recognized by spontaneous responses using an unbiased proteomic approach. Experimental Design: Protein fractionations tissue lysates from (n = 4) were performed. Fractions tested IFNγ ELISpot assay recognition through patients' T cells. Proteins immunogenic fractions identified mass spectrometry and validated in silico-predicted...