A5018215606- Glioma Diagnosis and Treatment
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- ATP Synthase and ATPases Research
- Nanoplatforms for cancer theranostics
- Cancer Research and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Organometallic Complex Synthesis and Catalysis
- Crystallization and Solubility Studies
- Nanocluster Synthesis and Applications
- X-ray Diffraction in Crystallography
- Cancer Immunotherapy and Biomarkers
- Bioinformatics and Genomic Networks
- Metal complexes synthesis and properties
- Catalytic Cross-Coupling Reactions
- Click Chemistry and Applications
- Immunotherapy and Immune Responses
- Neuroendocrine regulation and behavior
- Mathematical Biology Tumor Growth
- Cancer Cells and Metastasis
- Conservation, Biodiversity, and Resource Management
- Chemokine receptors and signaling
- Catalytic C–H Functionalization Methods
Heidelberg University
2017-2025
University Hospital Heidelberg
2017-2025
Heidelberg University
2020
University of Pavia
2016
Abstract Purpose: Targeting immunosuppressive and pro-tumorigenic glioblastoma (GBM)-associated macrophages microglial cells (GAM) has great potential to improve patient outcomes. Colony-stimulating factor-1 receptor (CSF1R) emerged as a promising target for reprograming anti-inflammatory M2-like GAMs. However, treatment data on patient-derived, tumor-educated GAMs their influence the adaptive immunity are lacking. Experimental Design: CD11b+-GAMs freshly isolated from tumors were treated...
Tumor organoids are important tools for cancer research, but current models have drawbacks that limit their applications predicting response to therapy. Here, we developed a fast, efficient, and complex culture system (IPTO, individualized patient tumor organoid) accurately recapitulates the cellular molecular pathology of human brain tumors. Patient-derived explants were cultured in induced pluripotent stem cell (iPSC)-derived cerebral organoids, thus enabling wide range tumors central...
Abstract The presence of genome-wide DNA hypermethylation is a hallmark lower grade gliomas (LGG) with isocitrate dehydrogenase (IDH) mutations. Further molecular classification IDH mutant defined by the (IDHmut-codel) or absence (IDHmut-noncodel) hemizygous codeletion chromosome arms 1p and 19q. Despite seen in bulk tumors, intra-tumoral heterogeneity at epigenetic level has not been thoroughly analyzed. To address this question, we performed first profiling single cells cohort 5 IDH1...
π-Systems based on six-membered phosphorus heterocycles are promising tools to investigate brain cancer.
Brain cancer, one of the most lethal diseases, urgently requires discovery novel theranostic agents. In this context, molecules based on six-membered phosphorus heterocycles - phosphaphenalenes are especially attractive; they possess unique characteristics that allow precise chemical engineering. Herein, we demonstrate subtle structural modifications phosphaphenalene-based gold(I) complexes lead to modify their electronic distribution, endow them with marked photophysical properties and...
Invited for the cover of this issue are groups Christel Herold-Mende and Carlos Romero-Nieto at Universities Heidelberg Castilla-La Mancha. The image depicts use phosphaphenalene gold(I) complexes treatment brain cancer. Read full text article 10.1002/chem.202104535.
Abstract Eosinophils, bone marrow-derived granulocytes involved in allergic asthma and autoimmunity, have attracted increasing attention due to their assumed role effective responses immune checkpoint blockade some extracranial tumors. However, the of this rare type cells immunologically cold tumors such as glioblastoma (GBM) has not been studied so far. When quantifying infiltrates levels 30 immune-relevant cytokines 60 matched pairs human primary recurrent GBM, strongest correlations (r=...
<div>AbstractPurpose:<p>Targeting immunosuppressive and pro-tumorigenic glioblastoma (GBM)-associated macrophages microglial cells (GAM) has great potential to improve patient outcomes. Colony-stimulating factor-1 receptor (CSF1R) emerged as a promising target for reprograming anti-inflammatory M2-like GAMs. However, treatment data on patient-derived, tumor-educated GAMs their influence the adaptive immunity are lacking.</p>Experimental...
Abstract Targeting immunosuppressive and protumorigenic glioblastoma-associated macrophages microglial cells (GAMs) holds great potential to improve patient outcomes. Although CSF1R has emerged as a promising target reprogram anti-inflammatory M2-like GAMs, relevant treatment data on human, tumor-educated GAMs innovative patient-derived 3D tumor organoid models study the influence adaptive immunity effectiveness of in complex entirely autologous setting are largely lacking. We performed...
<p>Gene set enrichment analyses of RNA sequencing data identifies enhanced antigen presentation in GW2580 and BLZ945-treated GAMs.</p>
<p>Gene set enrichment analyses of RNA sequencing data identifies enhanced antigen presentation in GW2580 and BLZ945-treated GAMs.</p>
<p>Live-cell imaging demonstrates accumulation of autologous T cells around tumor and the induction cell apoptosis.</p>
<p>Expression levels of CSF1R, CD163 and HLA-DR</p>
<p>Differential gene expression of BLZ945- and PLX3397-treated GAMs.</p>
<p>Changes in the cellular composition and proliferative activity pGBM patient-derived tumor organoids upon treatment with PLX3397 or BLZ945.</p>
<p>Supplementary Material and Methods</p>