A5103081123- Gastric Cancer Management and Outcomes
- Parasitic infections in humans and animals
- Traditional Chinese Medicine Analysis
- Parasitic Infections and Diagnostics
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Retinal and Macular Surgery
- Esophageal Cancer Research and Treatment
- Natural product bioactivities and synthesis
- Esophageal and GI Pathology
- Retinal Diseases and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Pharmacogenetics and Drug Metabolism
- Spondyloarthritis Studies and Treatments
- Helicobacter pylori-related gastroenterology studies
- Cytomegalovirus and herpesvirus research
- Cardiac, Anesthesia and Surgical Outcomes
- HIV/AIDS drug development and treatment
- Spine and Intervertebral Disc Pathology
- Cancer Cells and Metastasis
- DNA Repair Mechanisms
- Congenital Anomalies and Fetal Surgery
- Metastasis and carcinoma case studies
- MicroRNA in disease regulation
- Retinal Development and Disorders
German Cancer Research Center
2025
DKFZ-ZMBH Alliance
2025
Heidelberg University
2025
Zhejiang Chinese Medical University
2021-2024
Shanghai Ninth People's Hospital
2016-2024
Shanghai Jiao Tong University
2017-2024
University of Chinese Academy of Sciences
2024
Institute of Geographic Sciences and Natural Resources Research
2024
Chinese Academy of Sciences
2024
First Affiliated Hospital of Xinjiang Medical University
2023
Abstract Recent advances in the genomics of glioblastoma (GBM) led to introduction molecular neuropathology but failed translate into treatment improvement. This is largely attributed genetic and phenotypic heterogeneity GBM, which are considered major obstacle GBM therapy. Here, we use advanced human GBM-like organoid (LEGO: L aboratory E ngineered G lioblastoma-like O rganoid) models provide an unprecedented comprehensive characterization LEGO using single-cell transcriptome, DNA...
ABSTRACT The NACHT, LRR, and PYD domains‐containing protein 3 (NLRP3) inflammasome plays an important role in a variety of diseases. However, the NLRP3 human intervertebral disc (IVD) degeneration remains unknown. In present study, we assessed expression levels its downstream targets caspase‐1 IL‐1β 45 degenerate seven nondegenerate IVD samples. correlation between scores NLRP3, caspase‐1, were also analyzed. mRNA three molecules (NLRP3, IL‐1β) higher IVDs group than controls (nondegenerate...
The acquisition of high-resolution above-ground-biomass (AGB) data cost-effectively and expeditiously represents a formidable challenge within the domain current ecosystem surveillance. Plot-based inventory, conventional approach for estimating validating remote sensing data, is nonetheless costly constrained in terms spatial coverage. expeditious advancements unmanned-aerial-vehicle (UAV) technology furnish potential to devise AGB equations that transcend traditional diameter-height-based...
Tumor organoids are important tools for cancer research, but current models have drawbacks that limit their applications predicting response to therapy. Here, we developed a fast, efficient, and complex culture system (IPTO, individualized patient tumor organoid) accurately recapitulates the cellular molecular pathology of human brain tumors. Patient-derived explants were cultured in induced pluripotent stem cell (iPSC)-derived cerebral organoids, thus enabling wide range tumors central...
Abstract Background Psoriasis is an inflammatory disease that affects many people. However, the causal effect of lipid metabolism on psoriasis has not yet been verified. This study aimed to identify genetic relationship between serum levels and psoriasis. Methods Bidirectional two‐sample Mendelian randomization (MR) was used analyse cholesterol The outcome forward causality test In analysis reverse causality, exposed, 79 single‐nucleotide polymorphisms were detected in genome‐wide...
Epithelial-mesenchymal transition (EMT) of the retinal pigment epithelial (RPE) cells is a critical step in pathogenesis proliferative vitreoretinopathy (PVR). Some microRNAs (miRNAs) participate regulating RPE cell EMT as post-transcriptional regulators. However, function miR-194 remains elusive. Here, role PVR was investigated.Retinal layers were obtained using laser capture microdissection (LCM). Gene expression at mRNA and protein level tissues examined quantitative reverse transcription...
Micro RNA s (mi s) are a subtype of small regulatory that involved in numerous biological processes through ‐induced silencing networks. In an attempt to explore the phylogeny mi across five platyhelminths, we integrated annotated and their full genomes. We identified conserved clusters and, particular, miR‐71/2 was from planarian parasitic flatworms expanded free‐living S chmidtea mediterranea . Analysis 22 loci provided compelling evidence most known platyhelminths. Meanwhile, also...
Signet ring cell carcinoma (SRCC) was previously thought to have a worse prognosis than differentiated gastric (DC). However, recent studies shown that its is related staging. Here, we analyzed the clinicopathological features and rate of lymph node metastasis (LNM) in 2166 patients with cancer (605 early 1561 advanced cases) who underwent gastrectomy dissection (D2) from 2016 2019. The LNM for cases 18.0% 74.2%, respectively. Regarding cases, SRCC similar DC (10% vs. 16.1%, p =0.224),...
Tenofovir (TFV) ester prodrugs, a class of nucleotide analogs (NAs), are the first-line clinical anti-hepatitis B virus (HBV) drugs with potent antiviral efficacy, low resistance rate and high safety. In this work, three marketed TFV drugs, tenofovir disoproxil fumarate (TDF), alafenamide (TAF) amibufenamide (TMF), were used as probes to investigate relationships among prodrug structures, pharmacokinetic characteristics, metabolic activations, pharmacological responses reveal key factors...
Abstract The cytidine deaminase, Apolipoprotein B mRNA editing enzyme catalytic subunit 3B (APOBEC3B, herein termed A3B), is a critical mutation driver that induces genomic instability in cancer by catalyzing cytosine-to-thymine (C-to-T) conversion and promoting replication stress (RS). However, the detailed function of A3B RS not fully determined it known whether mechanism action can be exploited for therapy. Here, we conducted an immunoprecipitation-mass spectrometry (IP-MS) study...
// Yi Zhang 1, * , Bingqiao Shen Dandan Yuyao Wang 1 Zhimin Tang Ni Xiaoliang Jin Min Luo Hao Sun Ping Gu Department of Ophthalmology, Shanghai Ninth People's Hospital, Jiaotong University School Medicine, 200011, China These authors contributed equally to this work Correspondence to: Luo, email: qiangson@sh163.net Sun, sunhao6666@126.com Gu, guping2009@126.com Keywords: retinal progenitor cells, microRNA (miR)-29a, RBM8A, proliferation, differentiation Received: December 02, 2016 Accepted:...
Abstract Guizhi Fuling capsule (GZFL), a traditional Chinese medicine formulation, is widely used in China to relieve pain from dysmenorrhea and now Phase II clinical trial the USA. Due low exposure of five main medicative ingredients (amygdalin, cinnamic acid, gallic paeoniflorin paeonol) GZFL human, strategy was built qualitatively quantitatively identify possible metabolites describe pharmacokinetic profiles human. In this strategy, LC-Q-TOF/MS structurally elucidate vivo ; time-based...
Abstract Pericytes and endothelial cells (ECs) constitute the fundamental components of blood vessels. While role ECs in tumor angiogenesis microenvironment is well appreciated, pericyte function tumors remains underexplored. In this study, we used pericyte-specific deletion nitric oxide (NO) receptor, soluble guanylate cyclase (sGC), to investigate via single-cell RNA sequencing how pericytes influence vascular niche microenvironment. Our findings demonstrate that sGC disrupts EC–pericyte...
Although metabolic reprogramming and redox imbalance are widely reported to be involved in chemo-resistance cancer treatment, much more attention was paid anti-cancer drug induced effect. Our previous studies showed that cells can develop P-gp overexpression-mediated intrinsic resistance the formation of 3D MCF-7 multi-cellular layers (MCLs) without any induction. However, whether functioned during this progress remained unrevealed. In our present study, LC-Q/TOF-MS GC-MS were used...
Chronic atrophic gastritis (CAG) can progress to gastric cancer (GC) thus requiring endoscopic surveillance. Here, we analyze various aspects of CAG progression, time, and mucosal background, guide reasonable patients with three or more endoscopies from 2010-2021 were included. All cases analyzed for rate time operative link on assessment (OLGA) staging, intestinal metaplasia (OLGIM) Kimura-Takemoto classification further analyzed. Additional investigation guideline-defined low-risk by...
Pedunculoside, a triterpene saponin derived from various Ilex species, holds potential as treatment for cardiovascular diseases. However, its clinical application is hindered by poor bioavailability, rapid elimination, and extensive intestinal metabolism to rotundic acid. To address these issues, water-soluble inclusion complex of pedunculoside, namely, the beta-CD polymer pedunculoside (pedunculoside–βCDP), was prepared in this study, comparative vitro stability pharmacokinetic behavior...
Most endoscopists believe that higher resolution improves lesion detection rates. However, existing studies primarily compared the rates of white light endoscopy (WLE) and other imaging modalities. Our previous study demonstrated advantages magnifying from general for detection, prompting further investigation into variations in across endoscopes with different resolutions. Endoscopic corresponding pathological data our medical unit over past 5 years were analyzed. We excluded...