A5101482306- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Innovative Teaching Methods
- Retinal and Macular Surgery
- Electronic Packaging and Soldering Technologies
- Extracellular vesicles in disease
- Aluminum Alloys Composites Properties
- Microstructure and mechanical properties
- Systemic Sclerosis and Related Diseases
- interferon and immune responses
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Bone Metabolism and Diseases
- NF-κB Signaling Pathways
- Biomedical and Engineering Education
- Skin Protection and Aging
- Advanced Measurement and Detection Methods
- Epoxy Resin Curing Processes
- Retinoids in leukemia and cellular processes
- Mesenchymal stem cell research
- Neuroinflammation and Neurodegeneration Mechanisms
- 3D IC and TSV technologies
Tongji University
2016-2025
Tongji Hospital
2022-2025
Zhejiang University
2025
First Affiliated Hospital Zhejiang University
2025
Shanghai Tenth People's Hospital
2013-2022
Southwest Medical University
2017
Beijing Jiaotong University
2015
Tianjin University of Technology and Education
2012
Shanxi Datong University
2010
Intel (United States)
2001-2010
Biochemistry and cellular biology courses for medical students at Tongji University include the assessment that provides with feedback to enhance their learning, which is a type of formative assessment. However, frequent instant guidance often absent or inconsistently included in teaching process. WeChat, most popular Chinese social media, was introduced biochemistry course. A WeChat official account (OA) set up as an interactive platform. Over period two semesters, OA sent 73 push...
Systemic sclerosis (SSc) is a disease that features severe fibrosis of the skin and lacks effective therapy. Bone marrow mesenchymal stem cell (BMSC)-derived extracellular vesicles (EVs) are potential cell-based tools for treatment SSc.BMSCs were isolated from bone mice identified with surface markers according to multilineage differentiation. EVs BMSC culture medium by ultracentrifugation Nanosight NS300 particle size analyzer, transmission electron microscopy (TEM), western blot. The...
To study the biological functions and applications of human amniotic epithelial cell-derived extracellular vesicles (hAEC-EVs), cargos hAEC-EVs were analyzed using miRNA sequencing proteomics analysis. The hAECs in this had specific characteristics. Multi-omics analyses showed that matrix (ECM) reorganization, inhibition excessive myofibroblasts, promotion target cell adhesion to ECM their primary functions. We evaluated application for corneal alkali burn healing rabbits elucidated...
Background: Melanoma is one of the most common malignancies, posing a significant health threat to patients, particularly in advanced stages due its high aggressiveness. Chemotherapy agents with biocompatibility and low susceptibility induce resistance are required for systematic management. Methods: Dendrimer-derived mimics (DMs) host defense peptides (HDPs), which were constructed by dendrimer core optimized ratios hydrophobic arm, used treat A375 cells HaCaT as control. Live/dead...
Perioperative management and lung function recovery are vital for cancer patients. We conducted an open-label, single-center, noninferiority, randomized controlled trial in China to evaluate the efficacy of digital therapeutic (DTx)-assisted vs. multidisciplinary (MM) perioperative patients with cancer. From July 2022 June 2023, 186 minimally invasive surgery were randomized, 147 completed study. The participants randomly assigned a 1:1 ratio receive DTx-assisted (n = 72) or traditional MM...
Human adipose tissue-derived stem cells (ADSCs) are an attractive multipotent cell source with therapeutic applicability across diverse fields for the repair and regeneration of acute chronically damaged tissues. In recent years, there has been increasing interest in ADSC tissue engineering applications. However, mechanisms underlying regulation proliferation not fully understood. Here we show that 47 transcripts up-regulated while 23 down-regulated compared to terminally differentiated...
ABSTRACT Macrophages play critical roles in wound healing process. They switch from “classically activated” (M1) phenotype the early inflammatory phase to “alternatively (M2) later phase. However, dynamic process of macrophage switching diabetic wounds burdened with bacteria is unclear. In this report, Pseudomonas aeruginosa , frequently detected foot ulcers, was inoculated into cutaneous db/db mice mimic bacterium‐infected healing. We observed that P. infection impaired and quickly promoted...
Epithelial-mesenchymal transition (EMT) of the retinal pigment epithelial (RPE) cells is a critical step in pathogenesis proliferative vitreoretinopathy (PVR). Some microRNAs (miRNAs) participate regulating RPE cell EMT as post-transcriptional regulators. However, function miR-194 remains elusive. Here, role PVR was investigated.Retinal layers were obtained using laser capture microdissection (LCM). Gene expression at mRNA and protein level tissues examined quantitative reverse transcription...
Purpose: This study aimed to explore the role of protein kinase A (PKA) pathway in proliferative vitreoretinopathy (PVR) and effect PKA inhibitor H89 on experimental PVR. Methods: Epiretinal membranes (ERMs) were acquired from PVR patients analyzed by frozen-section immunofluorescence. An vivo model was developed intravitreal injecting rat eyes with ARPE-19 cells platelet-rich plasma, changes eye structures vision function observed. vitro epithelial-mesenchymal transition (EMT) cell...
A new Tuber species, T. sinoaestivum , is described from southwestern China based on morphological and molecular analyses. The which was found fruiting in association with Pinus armandii has been previously misidentified as aestivum (= uncinatum ). Although morphologically quite similar, differs the European species by more globose ascospores ornamented a shallower reticulum. ITS sequence analyses show only 92% similarity between two further supporting taxonomic separation of .
Adipose-derived stem cells (ASCs) have shown a strong protective effect on retinal degenerative diseases (RDD) after being transplanted into the subretinal space in an animal model. Recently, several clinical trials been conducted to treat RDD with intravitreal transplantation of cells, including ASCs. However, outcomes were not satisfactory. To investigate if site alters outcome cell-based therapy for RDD, we isolated rat ASCs (rASCs) and labeled them green fluorescent protein. Autologous...
Epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells is a key pathological event in proliferative diseases such as vitreoretinopathy (PVR). This study aimed to explore new method reverse EMT RPE develop an improved therapy for diseases.In vitro, human embryonic stem cell-derived were passaged and cultured at low density extended period time establish model. At different stages after treatment with known molecules or combinations molecules, the morphology was...
Age-related macular degeneration (AMD) is a major vision-threatening disease. Although mesenchymal stem cells (MSCs) exhibit beneficial neural protective effects, their limited differentiation capacity in vivo attenuates therapeutic function. Therefore, the of MSCs into retinal pigment epithelial (RPE) vitro and subsequent transplantation subretinal space expected to improve outcome cell therapy. Here, we transdifferentiated human umbilical cord (hUCMSCs) induced RPE (iRPE) using cocktail...
Background: Animal models play critical roles in studies of the etiology and therapy retinal degeneration (RD). Objective: To establish an RD model without severe systemic side effects monkeys. Methods: Cynomolgus monkeys Sprague-Dawley rats were treated with intravenous intravitreal sodium iodate (SI). Electroretinographic (ERG) recording, fluorescein fundus angiography (FFA), optical coherence tomography (OCT) a morphology examination conducted to evaluate function structure. ARPE-19 cells...
Abstract Background T helper 2 (Th2) cells are thought to play critical roles in allergic conjunctivitis (AC). They release inflammatory cytokines promote an response AC. Due individual heterogeneity and long-term chronic management, current therapies do not always effectively control Mesenchymal stem (MSCs) have been shown be effective treating allergy-related disorders, but it is unclear how exactly the Th2-mediated attenuated. This study aims elucidate therapeutic effect mechanism of...
Abstract Purpose To explore the function and regulatory mechanism of IFITM3 in mouse neural retinal progenitor cells (mNRPCs), which was found to be very important not only development retina embryos but also NRPCs after birth. Methods Published single-cell sequencing data were used analyze expression mNRPCs. RNA interference knock down IFITM3. CCK-8 assays cell viability. RNA-seq assess mRNA expression, as confirmed by real-time quantitative PCR, immunofluorescence western blots validate...