A5101973729- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Cancer Cells and Metastasis
- Functional Brain Connectivity Studies
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Advanced Radiotherapy Techniques
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Lung Cancer Research Studies
- Nanoplatforms for cancer theranostics
- Gut microbiota and health
- Photoacoustic and Ultrasonic Imaging
- Radiomics and Machine Learning in Medical Imaging
- Advanced Neuroimaging Techniques and Applications
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Surgical Treatments
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Dielectric materials and actuators
- Cancer Diagnosis and Treatment
- Urticaria and Related Conditions
Beijing Academy of Science and Technology
2025
Sun Yat-sen University
2020-2025
The Seventh Affiliated Hospital of Sun Yat-sen University
2020-2025
Sichuan University
2014-2025
West China Hospital of Sichuan University
2023-2025
State Key Laboratory of Biotherapy
2022-2024
Yan'an Hospital Affiliated To Kunming Medical University
2019-2024
Hangzhou Medical College
2024
Zhejiang University
2020-2024
The First Hospital of Kunming
2024
Abstract The cell identity of malignant cells and how they acquire it are fundamental for our understanding cancer. Here, we report that esophageal squamous carcinoma (ESCC) display molecular features equally similar but distinct to all three types normal epithelial cells, which term as confused (CCI). CCI is an independent prognostic marker associated with poor prognosis in ESCC. Further, identify tropomyosin 4 (TPM4) a critical gene promotes the aggressiveness ESCC vitro vivo. And TPM4...
It is well-known that thermally activated delayed fluorescence (TADF) always generated from charge-transfer (CT) excited states in donor-acceptor (D-A) systems, which limits its application owing to a slow radiative process and small stimulated emission cross section. Herein, design strategy proposed for realizing TADF locally (LE) state without typical type structure through controlling the intersystem crossing (ISC) reverse (RISC) processes between lowest singlet with LE character higher...
Characterized by nucleus pulposus (NP) cell senescence and extracellular matrix (ECM) degradation, disc degeneration is a common pathology for various degenerative spinal disorders. To date, effective treatments are absent. Here, we found that Glutaredoxin3 (GLRX3) an important redox-regulating molecule associated with NP degeneration. Using hypoxic preconditioning method, developed GLRX3+ mesenchymal stem cell-derived vehicles (EVs-GLRX3), which enhanced the cellular antioxidant defense,...
Disc degeneration is the common pathology underlying various degenerative spinal disorders and currently there no effective cure. Here, we found nucleus pulposus (NP) cell senescence was closely associated with severity of disc degeneration, exosomes (Exos) derived from mesenchymal stem cells (MSCs) ameliorated NP promoted extracellular matrix (ECM) deposition. As chitosan-based hydrogels have been widely used as vehicles to deliver Exos due their prominent antibacterial capacity,...
We have previously demonstrated the anticancer effect of anthocyanins. In this study, we explored biological activities delphinidin, most common anthocyanidin monomers, that were related to autophagy in HER-2 positive breast cancer MDA-MB-453 and BT474 cells. The effects various doses delphinidin on proliferation apoptosis cells analysed. Autophagy was identified as a critical factor influenced chemotherapy, autophagic mechanism delphinidin-treated investigated. inhibitors, 3-MA BA1, used...
Modulating the surface properties of nanoparticles (NPs) is an important approach to accomplish immune escape, prolonged blood retention time, and enhance ability targeted drug delivery. The camouflage cancer cell membrane onto has been proved be ideal active targeting NPs. Herein, we isolated melanoma cells coat doxorubicin (DOX) indocyanine green (ICG)-loaded hollow copper sulfide NPs (ID-HCuSNP@B16F10) for photothermal therapy, photoacoustic imaging, chemotherapy. A remarkable in vitro...
Network neuroscience has broadly conceptualized the functions of brain as complex communication within and between large-scale neural networks. Nevertheless, whether how gut microbiota influence functional network connectivity that in turn impact human behaviors yet to be determined. We collected fecal samples from 157 healthy young adults used 16S sequencing assess microbial diversity enterotypes. Large-scale inter- intranetwork was measured using a combination resting-state MRI data...
The spatial separation between the highest occupied and lowest unoccupied molecular orbitals (HOMO LUMO) in thermally activated delayed fluorescent (TADF) molecules leads to charge transfer (CT) states, which degrade oscillator strength of emission transition sacrifices high solid-state photoluminescence quantum yield (PLQY), together limiting its application organic lasers (OSSLs). Here, we demonstrated microwire from TADF emitters that combine aggregation induced (AIE) local excited (LE)...
Abstract Ovarian cancer (OC) is a major cause of gynecological mortality, necessitating enhanced research. Organoids, cellular clusters grown in 3D model, have emerged as disruptive paradigm, transcending the limitations inherent to conventional models by faithfully recapitulating key morphological, histological, and genetic attributes. This review undertakes comprehensive exploration potential organoids derived from murine, healthy population, patient origins, encompassing spectrum that...
Sigmoid colon cancer with spinal metastases is rare in distant metastasis. In addition, the prognosis of patients extremely poor. order to find effective therapeutic agents, we need know biological characteristics such from related models. We collected sigmoid tissue a young female subject who was diagnosed multiple metastases. successfully established organoid using this and investigated drug screening patient. HE staining, immunohistochemistry, DNA sequencing were utilized compare between...
A novel photoelectrochemical (PEC) biosensor was proposed by preparing Au NP/MXene–BiOCl Moiré superlattice nanosheets as the probes. Upon irradiation with visible light, probe exhibited excellent electrical conductivity well high photoelectric conversion efficiency. Benefitting from PEC property of hybrid probe, sensitive and accurate detection protein kinase activity demonstrated a limit 0.0029 U mL−1. This study verifies great potential MXene nanomaterials.
Post-operative recurrence rates of stage I non-small cell lung cancer (NSCLC) range from 20% to 40%. Nonetheless, the molecular mechanisms underlying hitherto remain largely elusive. Here, we generate genomic, epigenomic and transcriptomic profiles paired tumors adjacent tissues 122 NSCLC patients, among which 57 patients develop after surgery during follow-up. Integrated analyses illustrate that presence predominantly solid or micropapillary histological subtypes, increased genomic...
Abstract Descemet’s membrane (DM) helps maintain phenotype and function of corneal endothelial cells under physiological conditions, while little is known about the DM in wound healing process. In current study, we performed vivo rabbit cell (CEC) injury via CEC scraping, which remained intact after CECs removal, or stripping, was removed together with CECs. We found corneas scraping group healed transparency restoration, there posterior fibrosis tissue formation stripping on day 14....
Background: Previous neuroimaging studies have demonstrated brain abnormalities in patients with hepatic diseases. However, the identified liver–brain associations are largely limited to disease-affected populations, and nature extent of such relations healthy subjects remain unclear. We hypothesized that serum liver function markers within a normal level would affect properties. Method: One hundred fifty-seven young adults underwent structural, resting-state functional, arterial spin...
Increasing evidence indicates that gut microbiota can influence cognition via the gut-brain axis, and brain networks play a critical role during process. However, little is known about how network topology structural-functional connectivity (SC-FC) coupling contribute to microbiota-related cognition. Fecal samples were collected from 157 healthy young adults, 16S amplicon sequencing was used assess diversity enterotypes. Topological properties of structural functional acquired by diffusion...