A5100391333- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Lung Cancer Research Studies
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Respiratory viral infections research
- Silicon Carbide Semiconductor Technologies
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Systemic Lupus Erythematosus Research
- TGF-β signaling in diseases
- Semiconductor materials and devices
- Biomarkers in Disease Mechanisms
- Pharmacological Effects of Natural Compounds
- Metastasis and carcinoma case studies
- Acute Myocardial Infarction Research
- Biosimilars and Bioanalytical Methods
- Ferroptosis and cancer prognosis
- S100 Proteins and Annexins
Temple University
2023-2024
Xiangya Hospital Central South University
2024
Zhejiang University
2014-2023
Dalian Medical University
2020-2023
First Affiliated Hospital of Dalian Medical University
2020-2023
Stomatology Hospital
2023
Affiliated Hospital of North Sichuan Medical College
2023
Tongde Hospital of Zhejiang Province
2020-2023
Tangshan Gongren Hospital
2022
Hebei University of Chinese Medicine
2022
Purpose: Despite favorable responses of chimeric antigen receptor (CAR)-engineered T-cell therapy in patients with hematologic malignancies, the outcome has been far from satisfactory treatment solid tumors, partially owing to development an immunosuppressive tumor microenvironment. To overcome this limitation, we engineered CAR T cells secreting checkpoint inhibitors (CPI) targeting PD-1 (CAR.αPD1-T) and evaluated their efficacy a human lung carcinoma xenograft mouse model.Experimental...
Adoptive cellular therapy based on chimeric antigen receptor (CAR)-engineered T (CAR-T) cells is a powerful form of cancer immunotherapy. CAR-T can be redirected to specifically recognize tumor-associated antigens (TAAs) and induce high levels antitumor activity. However, they may also display "on-target off-tumor" toxicities, resulting from low-level expression TAAs in healthy tissues. These adverse effects have raised considerable safety concerns limited the clinical application this...
The transforming growth factor-β (TGF-β) pathway plays a pivotal role in inducing epithelial-mesenchymal transition (EMT), which is key step cancer invasion and metastasis. However, the regulatory mechanism of TGF-β EMT colorectal (CRC) has not been fully elucidated. In previous studies, it was found that S100A8 may regulate EMT. This study aimed to clarify TGF-β-induced explore underlying CRC.S100A8 upstream transcription factor 2 (USF2) expression detected by immunohistochemistry 412 CRC...
The immune contexture, a composition of the tumor microenvironment, plays multiple important roles in cancer stem cell (CSC) and epithelial–mesenchymal transition (EMT), hence critically influences initiation, progression patient outcome. Tumor-associated macrophages (TAMs) are abundant however their CSC, EMT prognosis colorectal (CRC) have not been elucidated. In 419 carcinomas, types (CD68+ macrophages, CD3+, CD4+ or CD8+ T lymphocytes, CD20+ B lymphocytes), markers (E-cadherin Snail) as...
Despite the remarkable success of chimeric antigen receptor-modified T (CAR-T) cell therapy for blood malignancies, clinical efficacy this novel in solid tumor treatment is largely limited by immunosuppressive microenvironment (TME). For instance, immune checkpoints (e.g., programmed death protein 1 [PD-1]/programmed ligand [PD-L1]) TME play an important role inhibiting proliferation and functions. Transforming growth factor β (TGF)-β secreted cancer cells induces regulatory (Tregs) inhibits...
Substantial evidence has shown that epithelial-mesenchymal transition (EMT) plays critical roles in colorectal cancer (CRC) development and prognosis. To uncover the pivotal regulators function cooperative interactions between cells their microenvironment consequently affect EMT process, we carried out a systematic analysis evaluated prognosis CRC specimens. Tumor buds surrounding stroma were captured using laser microdissection. We used gene expression profiling, bioinformatics regulatory...
Chimeric antigen receptor (CAR) engineering is a branch of cancer immunotherapy that equips immune cells to target tumor antigens expressed on the cell surface using antibody-derived single-chain variable fragments (scFvs). However, other antibody mimetics, such as designed ankyrin repeat proteins (DARPins), can also serve antigen-binding domains in CARs. This study shows CAR-engineered T (CAR-T) utilizing Her2-targeting DARPins G3 and 929 human epidermal growth factor 2...
Abstract Pancreatic neuroendocrine tumor (pancreatic NET s), is an important cause of cancer‐related death worldwide. No study has rigorously explored the impact ethnicity on pancreatic s. We aimed to demonstrate relationship between and survival patients with used SEER database identify s from 2004 2013. Kaplan–Meier methods Cox proportional hazard models were evaluate race in patients. A total 3850 included: 3357 Non‐Blacks, 493 Blacks. stratified races as “Black” “White/Other.” Blacks...
Background: Previous neuroimaging studies have demonstrated brain abnormalities in patients with hepatic diseases. However, the identified liver–brain associations are largely limited to disease-affected populations, and nature extent of such relations healthy subjects remain unclear. We hypothesized that serum liver function markers within a normal level would affect properties. Method: One hundred fifty-seven young adults underwent structural, resting-state functional, arterial spin...
Gene microarray and bioinformatic analysis showed that S100A8 was more abundant in the stroma surrounding tumor buddings (TBs) than primary cells colorectal carcinomas. Here, S100A8+ 419 carcinoma samples were stained by immunohistochemistry counted using Image-pro plus 6.0. TBs also biomarkers associated with epithelial–mesenchymal transition apoptosis assessed immunohistochemistry. We evaluated association between clinico-pathological variables as well survival. Migration invasion of...
Abstract Higher incidence and worse outcomes of laryngospasm during general anesthesia in children than adults have been reported for many years, but few prevention measures are put forward. Efficacy lidocaine has argued years we decided to design this network meta-analysis assess the efficacy lidocaine. We conducted an electronic search six sources finally included 12 Randomized Controlled Trials including 1416 patients. A direct comparison between placebo revealed had effect on preventing...
The purpose of this study was to verify the effect berberine (BBR) on endoplasmic reticulum stress (ERS) and apoptosis intestinal epithelial cells (IECs) in mice with ulcerative colitis (UC). BALB/c were randomly divided into five groups as follows: blank control, model, low‐, medium‐, high‐dose BBR. A dextran sodium sulfate‐ (DSS‐) induced model UC prepared, BBR simultaneously gavaged a suspension for 7 d. Disease activity index (DAI) assessed, tissue damage (TDI) assessed from colon...
Pappalysin 2 (PAPPA2) mutation, occurring most frequently in skin cutaneous melanoma (SKCM) and non-small cell lung cancer (NSCLC), is found to be related anti-tumour immune response. However, the association between PAPPA2 efficacy of checkpoint inhibitors (ICIs) therapy remains unknown.To analyse performance mutation as an indicator stratifying beneficiaries ICIs, seven public cohorts with whole-exome sequencing (WES) data were divided into NSCLC set (n = 165) SKCM 210). For further...
Objective: This study was to investigate a novel antibacterial biomimetic mineralization strategy for exploring its potential application root canal disinfection when stabilized cerium oxide used. Material and Methods: A solution (BMS) consisting of nitrate dextran prepared. Single-layer collagen fibrils, membranes, demineralized dentin, system were treated with the BMS mineralization. The mineralized samples underwent comprehensive characterization using various techniques, including...
The epithelial–mesenchymal transition (EMT) of tubular epithelial cells to myofibroblast-like plays a substantial role in renal tubulointerstitial fibrosis, which is common pathological character end-stage disease (ESRD). Fibroblast growth factor-2 (FGF-2) triggers EMT and increases Bcl-2-associated athanogene 3 (BAG3) expression neural progenitor neuroblastoma cells. In addition, novel regulation has been ascribed BAG3 recently. These previous reports urged us study the potential...
We report on near-infrared (NIR) electroluminescence (EL) from the light-emitting devices based Nd-doped TiO2/p+-Si heterostructures. NIR emissions peaking at ∼910, 1090, and 1370 nm, originated intra-4f transitions in Nd3+ ions, can be activated by a forward bias voltage as low ∼5 V. Such EL is triggered energy transferred TiO2 host to ions. It found that coexistence of anatase rutile phases enables device exhibit pronounced Nd-related without concurrent emission itself, quite other than...
Childhood-onset systemic lupus erythematosus (cSLE) is a kind of chronic inflammatory disease characterized by highly abnormal immune system. This study aimed to detect the serum levels Th (T helper) cytokines (IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-13, IL-17A, IL-17F, IL-21, IL-22, IFN-γ and TNF-α) in cSLE healthy controls, then elucidate their association with clinical manifestations, activity laboratory parameters. In order provide clues for early diagnosis timely intervention treatment...
A key molecule in the pathogenesis of Alzheimer's disease (AD) is a 42-amino acid isoform amyloid-β peptide (Aβ42), which most toxic element senile plaques. In this study, to develop an edible, safe, low-cost vaccine for AD, cholera toxin B subunit (CTB)-Aβ42 fusion protein was successfully expressed silkworm pupae. We tested pupae-derived oral vaccination containing CTB-Aβ42 transgenic mouse model AD. Anti-Aβ42 antibodies were induced these mice, leading decreased Aβ deposition brain. also...