A5101950528- Metal complexes synthesis and properties
- Ferrocene Chemistry and Applications
- DNA and Nucleic Acid Chemistry
- Organometallic Complex Synthesis and Catalysis
- Magnetism in coordination complexes
- Advanced biosensing and bioanalysis techniques
- Analytical chemistry methods development
- CAR-T cell therapy research
- Click Chemistry and Applications
- Adsorption and biosorption for pollutant removal
- Virus-based gene therapy research
- HIV/AIDS drug development and treatment
- Synthesis and Biological Evaluation
- Lanthanide and Transition Metal Complexes
- Synthesis and Characterization of Heterocyclic Compounds
- Molecular Communication and Nanonetworks
- Immunotherapy and Immune Responses
- RNA and protein synthesis mechanisms
- Micro and Nano Robotics
- Inorganic and Organometallic Chemistry
- Synthesis and biological activity
- Chemical Synthesis and Analysis
- Nanocluster Synthesis and Applications
- Nanomaterials for catalytic reactions
- Asymmetric Hydrogenation and Catalysis
City University of Hong Kong
2023-2024
Virginia Commonwealth University
2007-2023
University of Southern California
2011-2023
Research Institute of Dallas
2022-2023
Suzhou Municipal Hospital
2023
Nanjing Medical University
2021-2023
Taiyuan University of Technology
2020-2022
Nanyang Technological University
2022
Southern California University for Professional Studies
2021
Viterbo University
2021
The DNA-binding profile of a novel, trinuclear platinum Phase I clinical agent (BBR3464) is summarized. structure BBR3464 best described as two trans-[PtCl(NH3)2] units linked by tetra-amine [trans-Pt(NH3)2{H2N(CH2)6NH2}2]2+ unit. +4 charge BBR3464, the presence at least Pt coordination capable binding to DNA, and consequences such DNA are remarkable departures from cisplatin structural paradigm. chemical biological features argue that drug should be considered first representative an...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA comparison of chemical reactivity, cytotoxicity, interstrand crosslinking and DNA sequence specificity bis(platinum) complexes containing monodentate or bidentate coordination spheres with their monomeric analogsNicholas Farrell, Y. Qu, L. Feng, B. Van HoutenCite this: Biochemistry 1990, 29, 41, 9522–9531Publication Date (Print):October 1, 1990Publication History Published online1 May 2002Published inissue 1 October...
Abstract The delivery of nucleic acid vaccine to stimulate host immune responses against Coronavirus disease 2019 shows promise. However, vaccines have drawbacks, including rapid clearance and poor cellular uptake, that limit their therapeutic potential. Microrobots can be engineered sustain release further control the interactions with cells are vital for robust vaccination. Here, 3D fabrication biocompatible biodegradable microrobots via two‐photon polymerization gelatin methacryloyl...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCytotoxicity and antitumor activity of bis(platinum) complexes. A novel class platinum complexes active in cell lines resistant to both cisplatin 1,2-diaminocyclohexane complexesNicholas Farrell, Yun Qu, Miles P. HackerCite this: J. Med. Chem. 1990, 33, 8, 2179–2184Publication Date (Print):August 1, 1990Publication History Published online1 May 2002Published inissue 1 August...
Despite the remarkable success of chimeric antigen receptor-modified T (CAR-T) cell therapy for blood malignancies, clinical efficacy this novel in solid tumor treatment is largely limited by immunosuppressive microenvironment (TME). For instance, immune checkpoints (e.g., programmed death protein 1 [PD-1]/programmed ligand [PD-L1]) TME play an important role inhibiting proliferation and functions. Transforming growth factor β (TGF)-β secreted cancer cells induces regulatory (Tregs) inhibits...
Abstract Multidrug combination therapy provides an effective strategy for malignant tumor treatment. This paper presents the development of a biodegradable microrobot on‐demand multidrug delivery. By combining magnetic targeting transportation with therapy, it is hypothesized that loading multiple drugs on different regions single can enhance synergistic effect cancer The using two together greater than each drug separately. Here, 3D‐printed inspired by fish structure three hydrogel...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffects of Geometric Isomerism and Ligand Substitution in Bifunctional Dinuclear Platinum Complexes on Binding Properties Conformational Changes DNAN. Farrell, T. G. Appleton, Y. Qu, J. D. Roberts, A. P. Soares Fontes, K. Skov, Wu, ZouCite this: Biochemistry 1995, 34, 47, 15480–15486Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November...
Hydrophilic Fe3O4-Au Janus nanoparticles have been synthesized through a facile aqueous solution-based Fe3O4 seed-mediated chemical reduction route, where Au can be in situ formed on surfaces of PVP-modified by adopting the well-known citrate route. The diameter controllably tuned range 3-12 nm simply changing initial molar ratio between sodium and auric acid. as-fabricated hydrophilic shown excellent catalytic performance with high activity recyclability due to synergetic effect nanoparticles.
In order to establish fundamental structural requirements for the antitumor activation of trans-platinum geometry, complexes general formulas [PtCl(2)(NH(3))L] (L = planar N donor) have been synthesized. The trans isomers, trans-[PtCl(2)(NH(3))(quinoline)] (3), trans-[PtCl(2)(NH(3))(thiazole)] (5), trans-[PtCl(2)(NH(3))(benzothiazole)] (7), and trans-[PtCl(2)(NH(3))(isoquinoline)] (8) cis isomers cis-[PtCl(2)(NH(3))(quinoline)] (4) cis-[PtCl(2)(NH(3))(thiazole)] (6) were characterized by...
Reported here is a detailed study of the kinetics and mechanism formation 1,4 GG interstrand cross-link by [{trans-PtCl(NH3)2}2(μ-NH2(CH2)nNH2)]2+ (1,1/t,t (n = 6), 1), prototype novel class platinum antitumor complexes. The reaction self-complementary 12-mer duplex 5'-{d(ATATGTACATAT)2} with 15N-1 has been studied at 298 K, pH 5.4, [1H,15N] HSQC 2D NMR spectroscopy. Initial electrostatic interactions are observed for 1 monoaqua monochloro species (2). Aquation to yield 2 occurs...
A new approach to the synthesis of novel bifunctional dinuclear platinum complexes with linear coordinating spermidine and spermine is reported. The synthetic pathway involves first three-step selective protection polyamines, giving bis(trifluoroacetyl)polyamines (1, 4), (tert-butoxycarbonyl)bis(trifluoroacetyl)polyamines (2, 5), (tert-butoxycarbonyl)polyamines (3, 6), respectively. platination at desired sites activated species cis- or trans-[PtCl2(NH3)2] (CDDP TDDP, respectively) produces...
A possible explanation for the low bioavailability of platinum antitumor compounds is their high reactivity with sulfur-containing tripeptide glutathione (GSH; deprotonated GSH = SG). located in intracellular matrix cell a normal concentration 5−10 mM. In vivo, only small fraction administered drug will migrate into cell, resulting relatively concentrations compared to that drug. The products reactions [{trans-PtCl(NH3)2}2-μ-{trans-Pt(NH3)2(NH2(CH2)6NH2)2}](NO3)4 (BBR3464; 1,0,1/t,t,t, n 6),...
Bis(platinum) complexes [{cis-PtCl2(NH3)}2H2N(CH2)nNH2] are a novel series of potential anticancer agents in which two cis-diamine(platinum) groups linked by an alkyldiamine variable length. These potentially tetrafunctional, unique feature comparison with known agents. Studies DNA interactions bis(platinum) cisplatin demonstrate significant differences. Investigations interstrand crosslink formation crosslinking short fragment is detected gel electrophoresis under denaturing conditions that...
The substitution-inert polynuclear platinum(II) complex (PPC) series, [{trans-Pt(NH3)2(NH2(CH2)nNH3)}2-μ-(trans-Pt(NH3)2(NH2(CH2)nNH2)2}](NO3)8, where n = 5 (AH78P), 6 (AH78 TriplatinNC) and 7 (AH78H), are potent non-covalent DNA binding agents nucleic acid recognition is achieved through use of the 'phosphate clamp' square-planar tetra-am(m)ine Pt(II) coordination units all form bidentate N–O–N complexes hydrogen bonding with phosphate oxygens. modular nature PPC–DNA interactions results in...
Chimeric antigen receptor (CAR) T cell therapy mediates unprecedented benefit in certain leukemias and lymphomas, but has yet to achieve similar success combating solid tumors. A substantial body of work indicates that the accumulation adenosine tumor microenvironment (TME) plays a crucial role abrogating immunotherapies. Adenosine deaminase 1 (ADA) catabolizes into inosine is indispensable for functional immune system. We have, first time, engineered CAR cells overexpress ADA. To...
The novel platinum drugs [{trans-PtCl(NH3)2}2H2N(CH2)nNH2]2+ (1,1/t,t) are currently undergoing preclinical development. bifunctional DNA binding of these agents allows comparison with that cisplatin [Farrell et al. (1995) Biochemistry, 34, 15480]. major lesion cisplatin, the 1,2-d(GpG) intrastrand adduct, produces a rigid, directed bend 30−35° into groove DNA. We have now completed structural analysis corresponding adduct formed dinuclear complexes. Gel retardation assays on 15−22 bp...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInteraction of bis(platinum) complexes with the mononucleotide 5'-guanosine monophosphate. Effect diamine linker and nature complex on product formationYun Qu Nicholas FarrellCite this: J. Am. Chem. Soc. 1991, 113, 13, 4851–4857Publication Date (Print):June 1, 1991Publication History Published online1 May 2002Published inissue 1 June 1991https://pubs.acs.org/doi/10.1021/ja00013a021https://doi.org/10.1021/ja00013a021research-articleACS...
The reactions of bis(platinum) complexes general formula [(PtClm(NH3)3-m)2(NH2(CH2)nNH2)]2(2-m)+ were studied with poly(dG-dC).poly(dG-dC), poly(dG-m5dC).poly(dG-m5dC) and poly(dG).poly(dC). When m = 0 (Complexes II, n 2,4) the are saturated 4+ cations capable only electrostatic interactions polynucleotide. Where 1 contain two monodentate platinum coordination spheres chloride trans to diamine bridge I, 2,4, 1,1/t,t). Complexes I give CD spectra characteristic a 'Z-like' conformation upon...