A5060064204- Metal complexes synthesis and properties
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Magnetism in coordination complexes
- Organometallic Complex Synthesis and Catalysis
- Lanthanide and Transition Metal Complexes
- Crystallography and molecular interactions
- Ferrocene Chemistry and Applications
- DNA and Nucleic Acid Chemistry
- Asymmetric Hydrogenation and Catalysis
- Metal-Catalyzed Oxygenation Mechanisms
- Crystal structures of chemical compounds
- Metal-Organic Frameworks: Synthesis and Applications
- Inorganic and Organometallic Chemistry
- Synthesis and Characterization of Heterocyclic Compounds
- Polyoxometalates: Synthesis and Applications
- Porphyrin and Phthalocyanine Chemistry
- Asymmetric Synthesis and Catalysis
- Radioactive element chemistry and processing
- Molecular Sensors and Ion Detection
- Coordination Chemistry and Organometallics
- Organometallic Compounds Synthesis and Characterization
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Nanoparticle-Based Drug Delivery
The University of Sydney
2014-2024
In-Q-Tel
2012-2014
Northern Plains Agricultural Research Laboratory
2010
UNSW Sydney
1998-2009
University of Warwick
2007-2009
University of Edinburgh
1997-2009
University of Strathclyde
2009
The University of Western Australia
1978-2008
James Cook University
2008
John Radcliffe Hospital
2007
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Discovery and Development of CisplatinRebecca A. Alderden , Matthew D. Hall Trevor W. Hambley View Author Information Centre for Heavy Metals Research, School Chemistry, The University Sydney, 2006 NSW, AustraliaCite this: J. Chem. Educ. 2006, 83, 5, 728Publication Date (Web):May 1, 2006Publication History Received3 August 2009Published online1 May 2006Published inissue 1 2006https://doi.org/10.1021/ed083p728Request reuse permissionsArticle...
1H NMR spectroscopy was used to study the oligonucleotide binding of Δ enantiomers [Ru(phen)2L]2+ where bidentate ligand L is 1,10-phenanthroline (phen), dipyrido[3,2-d:2',3'-f]quinoxaline (dpq) or dipyrido[3,2-a:2',3'-c](6,7,8,9-tetrahydro)phenazine (dpqC). The data from one- and two-dimensional experiments oligonucleotide−metal complex suggest that all three ruthenium(II) polypyridyl complexes bind in DNA minor groove. While a minimally intercalated mode may be proposed for...
Metals and metal complexes can make multiple contributions to drug development, but are not receiving the attention they merit.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetal ion encapsulation: cobalt cages derived from polyamines, formaldehyde, and nitromethaneR. J. Geue, T. W. Hambley, M. Harrowfield, A. Sargeson, R. SnowCite this: Am. Chem. Soc. 1984, 106, 19, 5478–5488Publication Date (Print):September 1, 1984Publication History Published online1 May 2002Published inissue 1 September 1984https://pubs.acs.org/doi/10.1021/ja00331a016https://doi.org/10.1021/ja00331a016research-articleACS PublicationsRequest reuse...
The potential for cobalt(III) complexes in medicine, as chaperones of bioactive ligands, and to target tumours through bioreductive activation, has been examined over the past 20 years. Despite this, chemical properties such reduction carrier ligands required optimal tumour targeting drug delivery have not optimised. Here we review chemistry design, recent developments understanding cellular fate these drugs.
In contrast to the Pt(IV) derivatives of cisplatin, oxaliplatin do not show expected correlation between electrochemical reduction potentials and rates by ascorbate. This is probably due lower ability amine carboxylato ligands form a bridge with reducing agents facilitate electron transfer.
Two major issues which hamper the use of anticancer drug cisplatin are development cancer cell resistance and its nephrotoxicity. One possible mechanism by is reported to develop a reduction in uptake across membrane. While passive has long been cited as an important contribution, far greater attention given active modes uptake, particularly recent research. Using unilamellar lipid vesicles together with stopped-flow kinetic method we show here that permeability coefficient increases...
The success of molecularly targeted agents, such as imatinib, has led to expectations a new era in anticancer drug development, and greatly increased focus on targeting strategy. However, the number successes date is small, recent results suggest that for instance, treating chronic myelogenous leukemia gastrointestinal stromal tumor may be exception rather than rule. Here, we argue search agents needs continue many fronts possible, not focused one strategy alone.
We present a bioreductively activated cobalt(III) carrier system for the delivery of curcumin with enhanced drug stability, tumour penetration and efficacy in hypoxic regions. Curcumin is natural product potent anticancer activity but low bioavailability serum stability. With aim overcoming these limitations, we prepared prodrug compared cytotoxicity cellular uptake those free drug. Using combination fluorescence lifetime imaging X-ray absorption spectroscopy, demonstrated that released from...
Facile strategies were developed for the versatile functionalization of platinum(IV) axial sites, allowing easy accessibility to unsymmetric mono- and mixed-carboxylato, as well symmetric di-substituted complexes. The first method involves direct oxidation carboxylation platinum(II) center using an appropriate peroxide carboxylate choice firstly yield a monocarboxylato monohydroxido complex. This intermediate can undergo further give rise mixed-carboxylato second activation by common...
Abstract Light‐activated prodrugs offer the potential for highly selective tumour targeting. However, application of many photoactivated chemotherapeutics is limited by a requirement oxygen, or short activation wavelengths that can damage surrounding tissue. Herein, we present series cobalt(III)‐curcumin be activated visible light under both oxygenated and hypoxic conditions. Furthermore, photoproduct controlled wavelength: green yields free curcumin, whereas blue induces photolysis curcumin...
Previous work has shown platinum drugs to differ in their effects on the peripheral nervous system. To test whether differential toxicity was due differences partitioning into system, we correlated hydrophobicity, reactivity, tissue accumulation and neurotoxicity of a series eight analogues. Neurotoxicity detected by measuring sensory nerve conduction velocity (SNCV) Wistar rats treated twice per week at maximum tolerated dose. Tissue concentrations were measured inductively coupled plasma...
The syntheses and spectral structural characterizations of Zn(II) indomethacin [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid = IndoH] complexes, as different solvent adducts, have been studied. complexes are unusual in that both monomeric dimeric formed this is the first example same carboxylato ligand binding via carboxylate oxygen atoms complexes. crystal structures Zn-Indo with N,N-dimethylacetamide (DMA), pyridine (Py), 1-methyl-2-pyrrolidinone (NMP), EtOH, MeOH...
The electrochemical reduction and DNA binding have been studied for a series of platinum(IV) complexes with Cl-, OH-, carboxylate anions as the axial ligands ; [Pt(en)Cl4], [Pt(en)Cl2(OH)2], [Pt(en)Cl2(OC(O)R)2], R = CH3, CH2CH3, CH2CH2CH3. Cathodic potentials vary by more than 650 mV tetrachloro complex reduced most readily dihydroxo least readily. correlates to DNA. influence reducing agent glutathione on platinum was found depend whether it added before or after Pt/DNA incubation. results...
1H-15N HSQC NMR spectroscopy is used to study the aquation reactions of cisplatin in 9 mM NaClO4 and phosphate (pH 6) solutions at 298 K. For first time a single reaction and, therefore, under set conditions, amounts all species formed are followed rates aquation, diaquation, related anation processes determined both media. Binding aquated Pt observed, but initial rate not affected by presence phosphate. The between 14-base-pair self-complementary oligonucleotide 5'-d(AATTGGTACCAATT)-3',...
In recent years there have been numerous major advances in the understanding of factors controlling all aspects platinum binding to DNA and consequences binding. The interaction with involves stages, including: aquation complex, preassociation DNA, monofunctional adduct formation, closure a bifunctional adduct, distortion recognition this distortion. review we outline how increased our each these steps implications for rational drug development.