A5056481563- Cannabis and Cannabinoid Research
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Psychedelics and Drug Studies
- Neutropenia and Cancer Infections
- Forensic Toxicology and Drug Analysis
- Lung Cancer Treatments and Mutations
- Metal complexes synthesis and properties
- Prenatal Substance Exposure Effects
- Pancreatic and Hepatic Oncology Research
- Drug Transport and Resistance Mechanisms
- Cancer therapeutics and mechanisms
- Biosimilars and Bioanalytical Methods
- Chronic Lymphocytic Leukemia Research
- Antibiotics Pharmacokinetics and Efficacy
- Lung Cancer Research Studies
- Lanthanide and Transition Metal Complexes
- Neurotransmitter Receptor Influence on Behavior
- Antimicrobial Resistance in Staphylococcus
- Sleep and Wakefulness Research
- Protein Degradation and Inhibitors
- Acute Lymphoblastic Leukemia research
- Bladder and Urothelial Cancer Treatments
- Multiple Myeloma Research and Treatments
- Glioma Diagnosis and Treatment
University of Newcastle Australia
2016-2025
Hunter Medical Research Institute
2018-2024
National Health and Medical Research Council
2022
Hunter Cancer Research Alliance
2015
St George's Hospital
2009-2013
St George Hospital
2007-2012
UNSW Sydney
1990-2012
South Australia Pathology
2011
St. George Hospital
2007
Sutherland Hospital
2007
Introduction: Chronic cannabis use has been associated with impaired cognition and elevated psychological symptoms, particularly psychotic-like experiences. While Δ9-tetrahydrocannabinol (THC) is thought to be primarily responsible for these deleterious effects, cannabidiol (CBD) purported have antipsychotic properties ameliorate cognitive, symptomatic, brain harms in users. However, this never tested a prolonged administration trial otherwise healthy Here, we report the first study of CBD...
Previous work has shown platinum drugs to differ in their effects on the peripheral nervous system. To test whether differential toxicity was due differences partitioning into system, we correlated hydrophobicity, reactivity, tissue accumulation and neurotoxicity of a series eight analogues. Neurotoxicity detected by measuring sensory nerve conduction velocity (SNCV) Wistar rats treated twice per week at maximum tolerated dose. Tissue concentrations were measured inductively coupled plasma...
Introduction: Chronic cannabis use is associated with neuroanatomical alterations in the hippocampus. While adverse impacts of are generally attributed to Δ9-tetrahydrocannabinol, emerging naturalistic evidence suggests cannabidiol (CBD) neuroprotective and may ameliorate brain harms use, including protection from hippocampal volume loss. This study examined whether prolonged administration CBD regular users within community could reverse or reduce characteristic chronic use. Materials...
486 Background: As a multitarget tyrosine kinase inhibitor, lenvatinib (LEN) efficacy and toxicity are dose-dependent, dose adjustment is common for toxicity. A therapeutic level of LEN has not been defined in renal cell carcinoma (RCC), leading to uncertainty whether the patient on an effective dose. also widely used combination with immune checkpoint inhibitor (ICI), adding complexity due overlapping In this investigator-initiated study, we aimed assess: A) inter- intra-patient variability...
Evaluating medicinal cannabis in clinical trials is important for informing its efficacy and safety care. Alongside the inherent practical challenges of conducting people receiving palliative care, operationalising with a product requires additional consideration legal, regulatory, ethical, feasibility, pharmacological requirements. This manuscript aims to explore these considerations when Our Phase I/IIb trial examined pharmacokinetic, toxicity secondary (efficacy) outcomes vaporised...
PREDICT-5FU aimed to document 5-fluorouracil (5FU) exposure in a cancer population and evaluate the feasibility of 5FU capecitabine therapeutic drug monitoring (TDM) patients receiving standard doses schedules. Multicentre, prospective, observational single-arm study. Eligible adult received (infusional ≥24 h) or capecitabine. Patients were treated for gastrointestinal, breast head-and-neck cancers at four Australian hospitals. TDM was performed consecutive cycles until target area under...
Rett syndrome (RTT), commonly caused by methyl-CpG-binding protein 2 (MECP2) pathogenic variants, has many comorbidities. Fifty to ninety percent of children with RTT have epilepsy, which is often drug-resistant. Cannabidivarin (CBDV), a non-hallucinogenic phytocannabinoid, shown benefit in MECP2 animal models. This phase 1 trial assessed the safety and tolerability CBDV female drug-resistant as well effect on mean monthly seizure frequency (MMSF), electroencephalogram (EEG), non-epilepsy...
Albendazole (ABZ) is a microtubule-targeting anthelmintic with remarkable activity against variety of human cancer cells. In this study, we examined if the antitumor ABZ could be enhanced by its combination other microtubule-binding agents.The interactions between and agents, paclitaxel, vinblastine, colchicine, 2-methoxyestradiol were characterized using median effect analysis method in HCT-116 colorectal cells DU145 prostate cell line. The mechanism underlying synergistic interaction...
Workplace drug testing in Australia is usually adherent to one of two standards, AS/NZS 4308:2008 for urine or AS 4760:2006 oral fluid. These standards prescribe the drugs tested, devices used and methodology followed by agency. However, they are not comprehensive many years workers have been able consume novel psychoactive substances avoid detection without consequences. Here, we present a validated method 32 Synthetic Stimulant Hallucogenic drugs, commonly sold as bath salts, cathinone,...
Optimizing antimicrobial therapy to attain drug exposure that limits the emergence of resistance, effectively treats infection, and reduces risk side effects is a particular importance in critically ill patients, whom normal functions are augmented or/and infected with pathogens less sensitive treatment. Achievement these goals can be enhanced by therapeutic monitoring (TDM) for many antibiotics. A liquid chromatography tandem mass spectrometry (LC-MS/MS) method presented here simultaneous...
Although cannabis has been used for several thousand years, the exact composition of cannabinoids patients are administered different symptoms remained largely unknown. While this absence catalogued information may be accepted in some cultures, use as a human product registered medicines setting requires knowing its so that doses can standardised between patients. This is particularly clinical trials currently under way to determine efficacy product. major interest prescribers well known –...
Abstract Alcohol use disorder (AUD) and methamphetamine (MUD) are prevalent have high adverse impacts on both the individual society. Current treatment strategies for these disorders ineffective at a population level. Lorcaserin, 5‐HT 2C receptor agonist, has shown potential reducing symptoms of substance disorder. This pilot study (initiated prior to market withdrawal) examined feasibility safety lorcaserin in people undergoing residential detoxification AUD MUD. was an open label where...
When quantifying therapeutic drugs using LC-MS/MS instrumentation in clinical laboratories, batch-mode analysis with a calibration curve consisting of 6-10 concentrations for each analyte is the most widely used approach. However, this an inefficient use technology since it increases cost, delays result availability and precludes random instrument access. Various alternative methods to reduce calibrator improve efficiency without compromising analytical quality have been investigated,...