A5017576409- Sleep and Wakefulness Research
- Neurotransmitter Receptor Influence on Behavior
- Circadian rhythm and melatonin
- Stress Responses and Cortisol
- Regulation of Appetite and Obesity
- Historical Art and Culture Studies
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Renaissance and Early Modern Studies
- Architecture and Art History Studies
- Sleep and related disorders
- Receptor Mechanisms and Signaling
- Historical Art and Architecture Studies
- Neural dynamics and brain function
- Art History and Market Analysis
- Atmospheric and Environmental Gas Dynamics
- Air Quality and Health Impacts
- Environmental Justice and Health Disparities
- Rangeland and Wildlife Management
- Neuroscience of respiration and sleep
- Noise Effects and Management
- Renaissance Literature and Culture
- Eating Disorders and Behaviors
- Pain Mechanisms and Treatments
Florey Institute of Neuroscience and Mental Health
2017-2024
The University of Melbourne
2017-2024
Hunter Medical Research Institute
2014-2024
Boston University
2023-2024
University of Washington
2024
University of Newcastle Australia
2014-2024
Milken Institute
2024
George Washington University
2024
Monash University
2024
University of Calgary
2024
In many human alcoholics, abstinence is self-imposed because of the negative consequences excessive alcohol use, and relapse often triggered by exposure to environmental contexts associated with prior drinking. We recently developed a rat model this condition in which we train alcohol-preferring P rats self-administer one context (A), punish alcohol-reinforced responding different (B), then test for seeking Contexts A B without or shock. Here, studied role projections nucleus accumbens (NAc)...
Humans with alcohol use disorder typically abstain because of the negative consequences associated excessive drinking, and exposure to contexts previously can trigger relapse. We used a rat model that captures characteristic this human condition: namely voluntary abstinence from contingent punishment. There is substantial variability in propensity relapse following extended periods abstinence, critical feature preventing successful treatment disorder. Here we examined acute or prolonged...
Impaired motivational drive is a key feature of depression. Chronic stress known antecedent to the development depression in humans and depressive-like states animals. Whilst there clear relationship between drive, mechanisms underpinning this association remain unclear. One hypothesis that endocrine system, via corticotropin-releasing hormone (CRH) paraventricular nucleus hypothalamus (PVN; PVN
Early life stress (ELS) is a known antecedent for the development of mood disorders such as depression. Orexin neurons drive arousal and motivated behaviors in response to stress. We tested hypothesis that ELS alters orexin system function leads an altered stress-induced behavioral phenotype adulthood. also investigated if voluntary exercise during adolescent could reverse ELS-induced changes. Male female Wistar rats were subjected maternal separation on postnatal days (PND) 2-14. A subset...
Key Clinical Message This case suggests using dual orexin receptor antagonists to treat alcohol use disorder and comorbid sleep disorders may be effective, commencing treatment in withdrawal continuing it prevent relapse. Abstract Effective medications for the of are limited. is partially due heterogenous nature symptomatology associated with abundance presenting comorbidities. One common, often overlooked, symptom that occurs during disruption. Here, we report a study participant insomnia....
Objectives. To evaluate associations between oil and gas development (OGD) mental health using cross-sectional data from a preconception cohort study, Pregnancy Study Online. Methods. We analyzed baseline prospective of US Canadian women aged 21 to 45 years who were attempting conception without fertility treatment (2013–2023). developed residential proximity measures for active OGD during preconception, including distance nearest site. At baseline, participants completed validated scales...
It is well-established that stress and negative affect trigger eating disorder symptoms the brains of men women respond to in different ways. Indeed, suffer disproportionately from emotional or stress-related eating, as well associated disorders such binge disorder. Nevertheless, our understanding precise neural circuits driving this maladaptive behavior, particularly women, remains limited. We recently established a clinically relevant model 'emotional' stress-induced whereby only female...
Abstract Overeating is a major contributing factor to obesity and related health complications. For women, in particular, negative emotions such as stress strongly influence eating behavior bingeing episodes. Modeling this type of binge rodents presents challenges: firstly, stress‐induced anorexia commonly observed therefore mild stressor required order observe an orexigenic effect. Second, many studies report using calorie restriction the behavior; yet does not necessarily reflect human...
Animal and human studies have demonstrated that early pain experiences can produce alterations in the nociceptive systems later life including increased sensitivity to mechanical, thermal, chemical stimuli. However, less is known about impact of neonatal immune challenge on future responses noxious stimuli reactivity neural substrates involved analgesia. Here we demonstrate rats exposed Lipopolysaccharide (LPS; 0.05 mg/kg IP, Salmonella enteritidis) during postnatal day (PND) 3 5 displayed...
Abstract Alcohol use disorder (AUD) and methamphetamine (MUD) are prevalent have high adverse impacts on both the individual society. Current treatment strategies for these disorders ineffective at a population level. Lorcaserin, 5‐HT 2C receptor agonist, has shown potential reducing symptoms of substance disorder. This pilot study (initiated prior to market withdrawal) examined feasibility safety lorcaserin in people undergoing residential detoxification AUD MUD. was an open label where...