A5077428234- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- RNA Research and Splicing
- Prion Diseases and Protein Misfolding
- Intracranial Aneurysms: Treatment and Complications
- Genetic Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Histone Deacetylase Inhibitors Research
- Parkinson's Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Spinal Fractures and Fixation Techniques
- Trigeminal Neuralgia and Treatments
- Neuroscience of respiration and sleep
- Neurotransmitter Receptor Influence on Behavior
- Drug Transport and Resistance Mechanisms
- Neurological disorders and treatments
- Sleep and Wakefulness Research
- 3D Printing in Biomedical Research
- Neural dynamics and brain function
- Autism Spectrum Disorder Research
- Neuroscience and Neural Engineering
- RNA Interference and Gene Delivery
- Animal Genetics and Reproduction
University of North Carolina at Chapel Hill
2021-2025
Neurology, Inc
2023
Pomona College
2019
National Institute on Drug Abuse
2016-2019
National Institutes of Health
2016-2019
OBJECTIVE Cerebral arterial vasospasm is a dreaded sequela of aneurysm rupture and can result in significant narrowing the surrounding vasculature subsequent cerebral ischemia. Treatment interventions are associated with distinct side effect profiles, including risk thrombosis worsened ischemia, which may be increased mortality—especially older adults. An improved understanding likelihood elderly patients would enable clinicians to better consider risks benefits prophylaxis this vulnerable...
TDP-43 proteinopathies including frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by aggregation mislocalization of the nucleic acid-binding protein subsequent neuronal dysfunction. Here, we developed endogenous models sporadic proteinopathy based on principle that disease-associated acetylation at lysine 145 (K145) alters conformation, impairs RNA-binding capacity, induces downstream mis-regulation target genes....
TDP-43 proteinopathies including frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by aggregation mislocalization of the nucleic acid-binding protein subsequent neuronal dysfunction. Here, we developed endogenous models sporadic proteinopathy based on principle that disease-associated acetylation at lysine 145 (K145) alters conformation, impairs RNA-binding capacity, induces downstream mis-regulation target genes....
Abstract The orbitofrontal cortex (OFC) is a brain region involved in higher-order decision-making. Rodent studies show that cocaine self-administration (CSA) reduces OFC contribution to goal-directed behavior and behavioral strategies avoid drug intake. This change function persists for many weeks after withdrawal, suggesting involvement the process of addiction. mechanisms underlying impaired by are not well-understood. However, implicate altered serotonin (5-HT) disrupted cognitive...
Transactive response DNA-binding protein of 43 kDa (TDP-43) is a highly conserved, ubiquitously expressed nucleic acid-binding that regulates DNA/RNA metabolism. Genetics and neuropathology studies have linked TDP-43 to several neuromuscular neurological disorders including amyotrophic lateral sclerosis (ALS) frontotemporal lobar degeneration (FTLD). Under pathological conditions, mislocalizes the cytoplasm where it forms insoluble, hyper-phosphorylated aggregates during disease progression....
Parkinson's disease is a progressive neurological disorder, marked by the loss of dopaminergic neurons in nigrostriatal pathway that leads to abnormal gait, rigidity, slowness movement, and tremor. The ability recapitulate measure sequelae rodent models important for studying evaluating potential therapeutics. Individual variability lesion severity injury progression are key factors 6-hydroxydopamine model require normalization when therapeutic effects. gait parameters were found be affected...
TDP-43 proteinopathies including frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by aggregation mislocalization of the nucleic-acid binding protein subsequent neuronal dysfunction. Here, we developed endogenous models sporadic proteinopathy based on principle that disease-associated acetylation at lysine 145 (K145) alters conformation, impairs RNA-binding capacity, induces downstream mis-regulation target genes....
Abstract Introduction In our article, we evaluate the effect of lumbar drainage on delayed cerebral ischemia and requirements for permanent cerebrospinal fluid diversion in patients with aneurysmal subarachnoid hemorrhage. Methods We performed a retrospective cohort study from 2014 to 2023 at University Arkansas Medical Sciences (UAMS) examining factors associated (n = 150) who had hemorrhage drain placed. The main outcomes examined were incidence ischemia, need diversion, neurologic...
Secreted amyloid precursor protein-alpha (sAPPα), generated by enzymatic processing of the APP, possesses a range neurotrophic and neuroprotective properties plays critical role in molecular mechanisms memory learning. One key active regions sAPPα is central APP domain (E2) that contains within it tripeptide sequence, RER. This sequence exposed on surface coiled coil substructure E2. RER has itself displayed memory-enhancing properties, can protect newly formed engrams from interference...
TDP-43 proteinopathies including frontotemporal lobar dementia (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by aggregation mislocalization of the nucleic-acid binding protein subsequent neuronal dysfunction. Here, we developed an endogenous model sporadic proteinopathy based on principle that disease-associated acetylation at lysine 145 (K145) alters conformation, impairs RNA-binding capacity, induces downstream mis-regulation target genes....
Abstract TDP-43 proteinopathies including frontotemporal lobar dementia (FTLD) and amyotrophic lateral sclerosis are neurodegenerative disorders characterized by aggregation mislocalization of subsequent neuronal dysfunction. Here, we developed an endogenous model sporadic proteinopathy based on the principle that disease-associated acetylation at lysine 145 (K145) alters conformation, impairs RNA-binding capacity, induces downstream mis-regulation target genes. Expression acetylation-mimic...
Abstract TDP-43 proteinopathies including frontotemporal lobar dementia (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by aggregation mislocalization of the nucleic-acid binding protein subsequent neuronal dysfunction. Here, we developed an endogenous model sporadic proteinopathy based on principle that disease-associated acetylation at lysine 145 (K145) alters conformation, impairs RNA-binding capacity, induces downstream mis-regulation target...
<title>Abstract</title> TDP-43 proteinopathies including frontotemporal lobar dementia (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by aggregation mislocalization of the nucleic-acid binding protein subsequent neuronal dysfunction. Here, we developed an endogenous model sporadic proteinopathy based on principle that disease-associated acetylation at lysine 145 (K145) alters conformation, impairs RNA-binding capacity, induces downstream...
Abstract TDP-43 proteinopathies including frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by aggregation mislocalization of the nucleic-acid binding protein subsequent neuronal dysfunction. Here, we developed endogenous models sporadic proteinopathy based on principle that disease-associated acetylation at lysine 145 (K145) alters conformation, impairs RNA-binding capacity, induces downstream mis-regulation target...