A5037106945- Nerve injury and regeneration
- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Endoplasmic Reticulum Stress and Disease
- Neurogenesis and neuroplasticity mechanisms
- Neurological disorders and treatments
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Cellular transport and secretion
- Neuroscience and Neural Engineering
- Nuclear Receptors and Signaling
- Adenosine and Purinergic Signaling
- Virus-based gene therapy research
- Alzheimer's disease research and treatments
- Pain Mechanisms and Treatments
- Immune cells in cancer
- Autism Spectrum Disorder Research
- Adipose Tissue and Metabolism
- Immune Response and Inflammation
- Intracerebral and Subarachnoid Hemorrhage Research
- Genetic Neurodegenerative Diseases
University of Helsinki
2016-2025
Queensland Museum
2022
Czech Academy of Sciences, Institute of Biotechnology
2003-2019
Biocenter Finland
2013-2018
Helsinki Institute of Physics
2015-2018
National Institute on Drug Abuse
2009-2012
National Institutes of Health
2009-2011
Institute of Pharmacology
2006
The recent discovery of meningeal lymphatic vessels (LVs) has raised interest in their possible involvement neuropathological processes, yet little is known about development or maintenance. We show here that LVs develop postnatally, appearing first around the foramina basal parts skull and spinal canal, sprouting along blood cranial nerves to various meninges surrounding central nervous system (CNS). VEGF-C, expressed mainly vascular smooth muscle cells, VEGFR3 endothelial cells were...
Molecular diversity of microglia, the resident immune cells in CNS, is reported. Whether microglial subsets characterized by expression specific proteins constitute subtypes with distinct functions has not been fully elucidated. Here we describe a subtype expressing enzyme arginase-1 (ARG1; that is, ARG1+ microglia) found predominantly basal forebrain and ventral striatum during early postnatal mouse development. microglia are enriched phagocytic inclusions exhibit molecular signature,...
Mesencephalic astrocyte-derived neurotrophic factor (MANF), also known as arginine-rich, mutated in early stage of tumors (ARMET), is a secreted protein that reduces endoplasmic reticulum (ER) stress. Previous studies have shown MANF mRNA expression and levels are increased the cerebral cortex after brain ischemia, condition induces ER The function during ischemia still not known. purpose this study was to examine protective effect ischemic injury. Recombinant human administrated locally...
Cerebral dopamine neurotrophic factor (CDNF) is a recently discovered protein, which belongs to the evolutionarily conserved CDNF/MANF family of factors. The degeneration neurons following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment well characterized, and efficacy in this model considered standard criterion for development parkinsonian therapies. MPTP neurotoxin, produces symptoms humans C57/Bl6 mice. To date, there are no reports about effects CDNF on neuron survival or...
Abstract During intracerebral hemorrhage (ICH), hematoma formation at the site of blood vessel damage results in local mechanical injury. Subsequently, erythrocytes lyse to release hemoglobin and heme, which act as neurotoxins induce inflammation secondary brain injury, resulting severe neurological deficits. Accelerating resorption mitigating hematoma-induced edema by modulating immune cells has potential a novel therapeutic strategy for functional recovery after ICH. Here, we show that...
Following the onset of an ischemic brain injury, excitatory neurotransmitter glutamate is released. The excitotoxic effects are a major contributor to pathogenesis stroke. aim this study was examine if overexpression transporter (GLT-1) reduces injury in rat model We generated adeno-associated viral (AAV) vector expressing GLT-1 cDNA (AAV-GLT1). Functional expression AAV-GLT1 confirmed by increased clearance rate non-stroke as measured vivo amperometry. injected into future cortical region...
Primate-specific genes and isoforms could provide insight into human brain diseases. Our bioinformatic analysis revealed that there are possibly five of GDNF gene with different pre- pro-regions by inter- intra-exon splicing. By using TaqMan primer probe sets, designed between exons, we verified the expression all isoforms. Furthermore, a novel GDNFOS was found to be transcribed from opposite strand gene. has four exons spliced GDNFOS1 GDNFOS2 long noncoding RNAs, GDNFOS3 encodes protein 105...
Cerebral ischemia activates endogenous reparative processes, such as increased proliferation of neural stem cells (NSCs) in the subventricular zone (SVZ) and migration progenitor (NPCs) toward ischemic area. However, this process is limited because most NPCs die shortly after injury or are unable to arrive at infarct boundary. In study, we demonstrate for first time that mesencephalic astrocyte-derived neurotrophic factor (MANF) protects NSCs against oxygen-glucose-deprivation-induced has a...
Delayed delivery of MANF to rat brain after ischemic stroke promotes functional recovery and recruits phagocytic immune cells.
Electrochemical sensors provide means for real-time monitoring of neurotransmitter release events, which is a relatively easy process in simple electrolytes. However, this does not apply to vitro environments. In cell culture media, competitively adsorbing molecules are present at concentrations up 350 000-fold excess compared the neurotransmitter-of-interest. Because detection dopamine and serotonin requires direct adsorption analyte electrode surface, significant loss sensitivity occurs...
Local inhibitory GABAergic and excitatory glutamatergic neurons are important for midbrain dopaminergic hindbrain serotonergic pathways controlling motivation, mood, voluntary movements. Such reside both within the nuclei, in adjacent brain structures, including rostromedial laterodorsal tegmental nuclei. Compared to monoaminergic neurons, development, heterogeneity, molecular characteristics of these regulatory poorly understood. We show here that different subgroups associated with nuclei...