The emergence of Generative Artificial Intelligence (GAI) has caused significant disruption to the traditional educational teaching ecosystem. GAI possesses remarkable capabilities in generating human-like text and boasts an extensive knowledge repository, thereby paving way for potential collaboration with humans. However, current research on collaborating within context remains insufficient methods are relatively limited. This study aims utilize such as Lag Sequential Analysis (LSA)...

Despite the remarkable success of chimeric antigen receptor-modified T (CAR-T) cell therapy for blood malignancies, clinical efficacy this novel in solid tumor treatment is largely limited by immunosuppressive microenvironment (TME). For instance, immune checkpoints (e.g., programmed death protein 1 [PD-1]/programmed ligand [PD-L1]) TME play an important role inhibiting proliferation and functions. Transforming growth factor β (TGF)-β secreted cancer cells induces regulatory (Tregs) inhibits...

Association rules mining is an important technology in data mining. FP-Growth (frequent-pattern growth) algorithm a classical association But the needs two times to scan database, which reduces efficiency of algorithm. Through study and algorithm, we worked out improved algorithms algorithm—Painting-Growth N (not) Painting-Growth (removes painting steps, uses another way achieve). We compared kinds with Experimental results show that more than 1050 less 10000 volume; performance better

Chimeric antigen receptor (CAR) T cell therapy mediates unprecedented benefit in certain leukemias and lymphomas, but has yet to achieve similar success combating solid tumors. A substantial body of work indicates that the accumulation adenosine tumor microenvironment (TME) plays a crucial role abrogating immunotherapies. Adenosine deaminase 1 (ADA) catabolizes into inosine is indispensable for functional immune system. We have, first time, engineered CAR cells overexpress ADA. To...

The aim of the present study was to evaluate effects catalpol administration on atherosclerosis. Atherogenesis induced by a high-cholesterol chow in male New Zealand White rabbits that were randomly assigned receive atorvastatin (5 mg/kg/day), or vehicle oral gavage for 12 weeks. sacrificed after weeks, and thoracic aorta serum collected further pathological molecular biological analysis. Catalpol resulted significantly attenuated atherosclerotic lesions. Total cholesterol, triglycerides,...

B-acute lymphoblastic leukemia (B-ALL) consists of dozens subtypes defined by distinct gene expression profiles (GEP) and various genetic lesions. With the application transcriptome sequencing (RNA [RNA-seq]), multiple novel have been identified, which lead to an advanced B-ALL classification risk-stratification system. However, complexity analyzing RNA-seq data for hinders implementation new taxonomy. Here, we introduce Molecular Diagnosis Acute Lymphoblastic Leukemia (MD-ALL), integrative...

To observe the effect of polydatin on proliferation and apoptosis cervical cancer HeLa cells explore its possible mechanism. The growth inhibitory was detected with MTT assay. After were treated different concentrations (50, 100, 150 μmol•L⁻¹) polydatin, assay used to detect cells; Acridine orange/ethidium bromide staining for morphological changes in apoptotic cells； Annexin/propidium iodide applied cell rate. In addition, flow cytometry employed analyze cycle distribution； RT-PCR Western...

The aim of the present study was to evaluate protective effect catalpol on vascular endothelial function in STZ-induced type 2 diabetes mellitus (T2DM) rats. 40 high-fat diet with rats were randomly divided into model group, low-dose, middle-dose and high-dose group (10, 50, 100 mg x kg(-1) d(-1)), 10 normal Wistar used as group. groups given an equivalent amount saline. All reagents administered by oral gavage for 6 weeks. After weeks, blood glucose lipids detected automatic biochemical...

3,4-Dihydroxyacetophenone (3,4-DHAP) is one herbal extract from bald Mao-dong-qing leaves. We reported that 3,4-DHAP had anti-inflammatory function by decreasing tumor necrosis factor-α (TNF-α) secretion in macrophages. The aim of the study was to examine effects on plasma and liver lipids, alanine aminotranferase (ALT) TNF-α level, vascular cell adhesion molecule-1 (VCAM-1) expression, plaque vulnerability inflammation hypercholesterolemia-induced atherosclerotic rabbits. Male New Zealand...

The NO-CO reaction on Rh(100) and Rh(111) is a prototypical catalytic system with various practical applications, including the treatment of automotive gas exhausts. With parameters derived from first-principles calculations, Brønsted-Evans-Polanyi (BEP) relation for steps surfaces fitted, which more accurate calculation effect interaction between adsorbates activation energy compared to basic BEP relation. Further, kinetic Monte Carlo (kMC) model systems constructed exploration system's...

Abstract Inspired by natural enzymes, hierarchical catalytic supramolecular nanostructures were developed the co‐assembly of hemin and glucose oxidase (or Au NPs) with photosensitive ferrocene–tyrosine (Fc‐Y) molecule. Illuminated white light, Fc‐Y molecules are polymerized co‐assemble into truncated polyhedrons. The NPs grew in situ at surface co‐assembled polyhedrons, achieving ordered nanostructures. Because can serve as an artificial could act a peroxidase mimic, hybrid used to mimic...

B-cell acute lymphoblastic leukemia (B-ALL) consists of dozens subtypes defined by distinct gene expression profiles (GEPs) and various genetic lesions. With the application transcriptome sequencing (RNA-seq), multiple novel have been identified, which lead to an advanced B-ALL classification risk-stratification system. However, complexity analyzing RNA-seq data for hinders implementation new taxonomy. Here, we introduce MD-ALL (Molecular Diagnosis ALL), a user-friendly platform featuring...

<h3>Background</h3> Mesothelin (MSLN) is a glycosylphosphatidylinositol (GPI)-anchored membrane protein with high expression levels in an array of malignancies including mesothelioma, ovaria, non-small cell lung cancer, and pancreatic cancers attractive target antigen for immune-based therapies. Early clinical evaluation autologous MSLN-targeted chimeric receptor (CAR)-T therapies malignant pleural mesothelioma has shown promising acceptable safety¹ have recently evolved...

It has been reported that oxidative stress plays a prominent role in diabetic macrovascular diseases. 3,4‑Dihydroxyacetophenone (3,4‑DHAP) found to have variety of biological activities. However, few studies assessed the antioxidant capacity 3,4‑DHAP and underlying mechanisms. Thus, aim present study was explore effects on human umbilical vein endothelial cells (HUVECs). HUVECs were pre‑treated with then exposed high glucose conditions. Cell viability cytotoxicity measured using an MTT...

In recent years, ensemble learning has garnered increasing attention within the field of machine learning. This is primarily because techniques have demonstrated their capability to enhance model performance. Ensemble enables amalgamation multiple weak learners into a single robust learner, leading improvements in overall One key benefits its ability reduce variance, robustness, and mitigate risk overfitting. Additionally, it contributes reducing data bias elevating stability....

Objective This study aims to evaluate the Guanfacine-associated adverse events (AEs) in real-world using data mining FAERS database, seeking provide safety profile and guidance for potential therapeutic practices.

To explore the genetic basis of cerebral palsy (CP).A pair twins with and different phenotypes were subjected to whole genome sequencing, other 8 children CP exome sequencing. Genetic variations screened by a self-designed filtration process in order CP-related biological pathways genes.Three related identified, which included axon guiding, transmission across chemical synapses protein-protein interactions at synapses, 25 susceptibility genes for identified.The molecular mechanism has been...