A5101992944- Ferroptosis and cancer prognosis
- Turtle Biology and Conservation
- Bioinformatics and Genomic Networks
- Sperm and Testicular Function
- Genetics, Bioinformatics, and Biomedical Research
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Head and Neck Cancer Studies
- Liver Disease Diagnosis and Treatment
- Mathematical and Theoretical Epidemiology and Ecology Models
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Stroke Rehabilitation and Recovery
- Animal Behavior and Reproduction
- Reproductive biology and impacts on aquatic species
- Traditional Chinese Medicine Studies
- Transcranial Magnetic Stimulation Studies
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Diet, Metabolism, and Disease
- Neuropeptides and Animal Physiology
- Extracellular vesicles in disease
- Esophageal Cancer Research and Treatment
Sichuan University
2023-2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2021-2024
Taian City Central Hospital
2022-2024
Qingdao University
2022-2024
Changhai Hospital
2019-2024
Second Military Medical University
2019-2024
Tianjin University of Sport
2024
State Key Laboratory of Food Science and Technology
2019-2024
Nanchang University
2019-2024
State Key Laboratory of Oral Diseases
2024
Abstract Copper plays pivotal roles in metabolic homoeostasis, but its potential role human tumorigenesis is not well defined. Here, it revealed that copper activates the phosphoinositide 3‐kinase (PI3K)‐protein kinase B (PKB, also termed AKT) oncogenic signaling pathway to facilitate tumorigenesis. Mechanistically, binds 3‐phosphoinositide dependent protein 1 (PDK1), turn promotes PDK1 binding and subsequently downstream substrate AKT Blocking transporter (CTR1)‐copper axis by either...
Pretreatment hematological markers of inflammatory response have emerged as prognostic factors for patients with cancer. In this study, we evaluated the significance various hematologic parameters in nasopharyngeal carcinoma (NPC).Clinical data from 251 NPC were retrospectively collected. Neutrophil counts, lymphocyte platelet neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte (PLR) adopted potential biomarkers. The Kaplan-Meier method log-rank test to calculate compare...
2509 Background: As a promising approach for some cancers, chimeric antigen receptor T cell therapy has limited success in solid tumors. Claudin18.2 (CLDN 18.2) is stomach-specific isoform of Claudin-18, and highly expressed gastric pancreatic adenocarcinoma, the advanced form both which have urgent unmet medical needs. We previously developed demonstrated ability CLDN 18.2-specific CAR (CAR-CLDN18.2) cells to eradicate 18.2-positive cancer xenografts without obvious on-target off-tumor...
Nasopharyngeal carcinoma (NPC) shows the highest invasive and metastatic features among head neck cancers. Distant metastasis remains predominant mode of treatment failure in NPC patients. The role interleukin-6 (IL-6) progression is not fully understood. In this study, we explored whether IL-6 could promote migration invasion activity cell lines, as well effect on mediated through regulating expression matrix metalloproteinase-2 (MMP-2) MMP-9. Our results revealed that its receptors are...
Background: Multiple studies have assessed the prognostic significance of serum lactate dehydrogenase (LDH) in patients with breast cancer, but their results remain controversial. This study aimed to evaluate value LDH cancer by meta-analysis. Methods: Electronic searches for relevant articles were conducted PubMed, Embase and Web Science databases. The HR 95% CI used assess LDH. Stata Statistical Software 12.0 was applied statistical analysis. Results: A total 11 involving 6,102 subjected...
Radiotherapy with or without concurrent chemotherapy is the standard treatment for nasopharyngeal carcinoma (NPC) patients, whose efficacy limited partly by intrinsic and acquired radioresistance. DNA methyltransferase 3B (DNMT3B) has been reported to participate in tumorigenesis via methylation, but its role mediating progression radioresistance of NPC remains unclear. Therefore, we conducted following studies explore relationship between DNMT3B NPC. Here, found that was elevated tissues...
Abstract Infected mandibular defects pose a formidable challenge without an entirely satisfactory repair strategy. Here, coaxial 3D printing scaffold comprising shell loaded is dveloped with the antibiotic minocycline hydrochloride and core wrapped traditional Chinese medicine antler powers. This study conducted to evaluate efficacy of in facilitating infected defects. In vitro investigations exhibit that this construct possesses porous microstructure, exceptional mechanical properties,...
Abstract Telocytes (Tcs) are cells with telopodes (Tps), which very long cellular extensions alternating thin segments (podomers) and dilated bead‐like thick regions known as podoms. Tcs a distinct category of interstitial have been identified in many mammalian organs including heart, lung kidney. The present study investigates the existence, ultrastructure, distribution contacts surrounding uterus (shell gland) oviduct C hinese soft‐shelled turtle, P elodiscus sinensis . Samples from...
Abstract Radiotherapy is the mainstay and primary curative treatment modality in nasopharyngeal carcinoma ( NPC ), whose efficacy limited by development of intrinsic acquired radioresistance. Thus, deciphering new molecular targets pathways essential for enhancing radiosensitivity . SALL 4 a vital factor prognosis various cancers, but its role radioresistance remains elusive. This study aimed to explore association expression with It was revealed that closely correlated advanced T...
The porous PMME/PEI/PDA/MXene scaffold was fabricated through the VIPS and dopamine-assisted co-deposition processes. as-prepared possesses anti-bacterial, ROS scavenging, osteogenic abilities.
Thirty phenolic ether derivatives of scopoletin modified at the 7-hydroxy position were synthesized, and their structures confirmed by IR, ¹H-NMR, 13C-NMR, MS elemental analysis. Preliminary acaricidal activities these compounds against female adults Tetranychus cinnabarinus (Boisduval) evaluated using slide-dip method. The results indicated that some exhibit more pronounced activity than scopoletin, especially 32, 20, 28, 27 8 which exhibited about 8.41-, 7.32-, 7.23-, 6.76-, 6.65-fold...
Combination drug therapy has become an effective strategy to control inflammation. Lipophilic grape seed proanthocyanidin (LGSP) and camellia oil (CO) have been independently investigated show anti-inflammatory effects, but their synergistic effects are unknown. The aim of this study was investigate the LGSP CO. activity CO individual or in combination on RAW264.7 cells detected by MTT assay, Griess reagent, RT-PCR, 2',7'-dichlorfluoroescein diacetate Western blot analysis. combined...
Hydrogen (H
Sperm storage in vivo extends the time window for fertilisation several animal species, from a few days to years. The underlying mechanisms, however, are largely unknown. In this study, spermatozoa epididymis and oviduct of Chinese soft-shelled turtles were investigated identify potentially relevant morphological features transformations at different stages sperm storage. Large cytoplasmic droplets (CDs) containing lipid (LDs) attached midpiece most epididymis, without migrating down tail....
Background: Pre-treatment serum lactate dehydrogenase (LDH) has emerged as prognostic factor for many cancers.In this study, we evaluated the value of LDH in predicting distant metastasis and poor survival patients with nasopharyngeal carcinoma (NPC).Methods: Clinical data from 172 non-metastatic NPC were retrospectively collected levels routinely measured before treatment.The independent-samples t test was used to calculate differences between various patient groups.Receiver-operating...
Epigallocatechin gallate (EGCG) is the predominant tea polyphenol and it exhibits a hydrophilic character. The lipophilized EGCG derivative (LEGCG) was synthesized by enzymatic esterification of with lauric acid to enhance its bioactivity. tetralauroyl confirmed high-performance liquid chromatography-tandem mass spectrometry further identified as 3′, 5′, 3″, 5″-4-O-lauroyl 1H 13C nuclear magnetic resonance. anti-proliferation effect LEGCG on DU145 human prostate carcinoma cells evaluated MTT...
Psoralea corylifolia L. (PC) is a traditional Chinese herb used to treat yang deficiency of the spleen and kidney in pediatric disease. Our previous studies have found that PC can alleviate liver oxidative stress juvenile mice with nonalcoholic steatohepatitis (NASH), its mechanism related inhibition protein kinase C-α (PKC-α)/nicotinamide-adenine dinucleotide phosphate oxidase (NOX) signaling pathway. The aim this study was confirm aforementioned drug target vitro conduct preliminary...