A5016150318- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Reproductive Biology and Fertility
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Photodynamic Therapy Research Studies
- Acne and Rosacea Treatments and Effects
- Peptidase Inhibition and Analysis
- Animal Genetics and Reproduction
- Antifungal resistance and susceptibility
- RNA modifications and cancer
- Endometriosis Research and Treatment
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Kruppel-like factors research
- Redox biology and oxidative stress
- Cancer-related gene regulation
- Fungal Infections and Studies
- Ovarian function and disorders
- Cancer, Hypoxia, and Metabolism
- Herpesvirus Infections and Treatments
- Genetic and rare skin diseases.
- Autoimmune and Inflammatory Disorders
- Cutaneous lymphoproliferative disorders research
Hainan University
2025
Soochow University
2016-2024
Jiangxi Agricultural University
2024
Chinese Academy of Medical Sciences Dermatology Hospital
2022-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2023
South China University of Technology
2022-2023
China Agricultural University
2017-2023
Guangzhou First People's Hospital
2023
Guangzhou Medical University
2023
First Affiliated Hospital of Soochow University
2016-2023
Abstract Copper plays pivotal roles in metabolic homoeostasis, but its potential role human tumorigenesis is not well defined. Here, it revealed that copper activates the phosphoinositide 3‐kinase (PI3K)‐protein kinase B (PKB, also termed AKT) oncogenic signaling pathway to facilitate tumorigenesis. Mechanistically, binds 3‐phosphoinositide dependent protein 1 (PDK1), turn promotes PDK1 binding and subsequently downstream substrate AKT Blocking transporter (CTR1)‐copper axis by either...
There is a growing interest in the role of timing daily behaviors improving health. However, little known about optimal physical activity to maximize health benefits. We perform cohort study 92,139 UK Biobank participants with valid accelerometer data and all-cause cause-specific mortality outcomes, comprising over 7 years median follow-up (638,825 person-years). Moderate-to-vigorous intensity (MVPA) at any time day associated lower risks for all-cause, cardiovascular disease, cancer...
Abstract In mammals, nonrenewable primordial follicles are activated in an orderly manner to maintain the longevity of reproductive life. Mammalian target rapamycin (mTOR)-KIT ligand (KITL) signaling pre-granulosa cells and phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt)-forkhead Box O3a (FOXO3a) oocytes important for follicle activation. The activation process is accompanied by enhancement energy metabolism, but causal relationship unclear. present study, levels...
Abstract Background 3-phosphoinositide-dependent protein kinase-1 (PDK1) acts as a master kinase of A, G, and C family (AGC) to predominantly govern cell survival, proliferation, metabolic homeostasis. Although the regulations PDK1 downstream substrates such B (AKT) ribosomal S6 beta (S6K) have been well established, upstream regulators PDK1, especially its degrader, has not defined yet. Method A clustered regularly interspaced short palindromic repeats (CRISPR)-based E3 ligase screening...
The majority of ovarian primordial follicles are preserved in a dormant state to maintain the female reproductive lifespan, and only few activated enter growing follicle pool each wave. Recent studies have shown that follicular activation depends on mammalian target rapamycin complex 1 (mTORC1)‐KIT ligand (KITL) signaling pre‐granulosa cells its receptor (KIT)‐phosphoinositol 3 kinase (PI3K) oocytes. However, upstream regulator mTORC1 is unclear. results present study showed phosphorylated...
Emerging evidence has demonstrated that microRNAs (miRNA) play a critical role in chemotherapy-induced epithelial-mesenchymal transition (EMT) glioma. However, the underlying mechanism of chemotherapy-triggered EMT not been fully understood. In current study, we determined miR-26b regulation stable temozolomide (TMZ)-resistant (TR) glioma cells, which have displayed mesenchymal features. Our results illustrated was significantly downregulated TR cells. Moreover, ectopic expression by its...
Rottlerin, a polyphenolic compound derived from Mallotus philipinensis, has been reported to exhibit anti-tumor activities in variety of human malignancies including NSCLC (non-small cell lung cancer). TAZ (transcriptional co-activator with PDZ-binding motif), one the key activators Hippo pathway, characterized as an oncoprotein. Therefore, inhibition could be useful for treatment cancers. In current study, we aimed explore whether rottlerin inhibits expression NSCLC, leading its anti-cancer...
// Yingying Hou 1, * , Shaoyan Feng 2, Lixia Wang 1 Zhe Zhao Jingna Su Xuyuan Yin Nana Zheng Xiuxia Zhou Jun Xia 3 and Zhiwei 3, 4 The Cyrus Tang Hematology Center Collaborative Innovation of Hematology, Soochow University, Suzhou, China 2 Department Otolaryngology, Head Neck Surgery, Fifth Affiliated Hospital Sun Yat-sen Zhuhai, Biochemistry Molecular Biology, Bengbu Medical College, Anhui, Pathology, Beth Israel Deaconess Center, Harvard School, Boston, MA, USA These authors have...
: The treatment of acne vulgaris is often challenging due to the antibiotic resistance frequently observed in Cutibacterium acnes (C.acnes), a prevalent bacterium linked this condition. objective research was examine impact curcumin photodynamic therapy (PDT) on survival C.acnes and activity biofilms produced by microorganism. Following Clinical Laboratory Standards Institute (CLSI) guidelines, we assessed drug sensitivity 25 clinical strains five antibiotics (erythromycin, clindamycin,...
Set8 is critically involved in transcription regulation, cell cycle progression and genomic stability. Emerging evidence has revealed that E3 ubiquitin ligases such as CRL4cdt2 SCFSkp2 regulate protein abundance. However, it unclear whether other ligase(s) could govern level for proper response to genotoxic stress UV irradiation. Recently, we report the SCFβ-TRCP complex regulates stability by targeting ubiquitination subsequent degradation. Notably, interacts with ligase complex. We further...
Abstract In mammals, dormant primordial follicles represent the ovarian reserve throughout reproductive life. vitro activation of has been used to treat patients with premature insufficiency (POI). However, there remains a lack effective strategies stimulate follicle in vivo. this study, we an culture system and intraperitoneal injection study effect lithium treatment on activation. Lithium increased number growing cultured mouse ovaries promoted pre-granulosa cell proliferation....