A5017269103- Immune Response and Inflammation
- Natural Compounds in Disease Treatment
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Intensive Care Unit Cognitive Disorders
- Angiogenesis and VEGF in Cancer
- Immune cells in cancer
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Telomeres, Telomerase, and Senescence
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Gut microbiota and health
- MicroRNA in disease regulation
- Sepsis Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Sphingolipid Metabolism and Signaling
- Cell death mechanisms and regulation
- Estrogen and related hormone effects
- Medical Research and Treatments
- Bioactive Compounds and Antitumor Agents
- Pregnancy and preeclampsia studies
- Cardiac Ischemia and Reperfusion
Soochow University
2015-2024
Shanghai Jiao Tong University
2021-2024
State Key Laboratory of Oncogene and Related Genes
2021-2023
Zunyi Medical University
2023
Emory University
2018-2022
Ruijin Hospital
2022
Shaanxi University of Chinese Medicine
2019-2021
University School
2021
Soochow University
2021
Shandong Provincial Hospital
2005-2019
The protective role of etanercept in myocardial ischemia/reperfusion is not well understood. aim this study was to investigate whether modulates neutrophil accumulation, TNF-α induction and oxidative stress an injured rat heart model. Rats were randomly exposed sham operation, (MI/R) alone, MI/R+ etanercept. results demonstrated that compared MI/R, reduced infarction area, myeloperoxidase (MPO) levels, serum creatinine kinase (CK) lactate dehydrogenase (LDH) both production. Etanercept also...
Sepsis-induced intestinal hyperpermeability is mediated by disruption of the epithelial tight junction, which closely associated with perijunctional actin-myosin ring. Myosin light chain kinase (MLCK) phosphorylates myosin regulatory chain, resulting in increased permeability. The purpose this study was to determine whether genetic deletion MLCK would alter gut barrier function and survival from sepsis. MLCK−/− wild-type (WT) mice were subjected cecal ligation puncture assayed for both...
Abstract Expression of the long non-coding RNA (lncRNA) keratin-7 antisense (KRT7-AS) is downregulated in various types cancer; however, impact KRT7-AS deficiency on tumorigenesis and apoptosis enigmatic. We aim to explore influence carcinogenesis apoptosis. found that was deficient breast lung cancers, low levels were a poor prognostic factor cancer. Cellular studies showed silencing cancer cells increased oncogenic Keratin-7 enhanced tumorigenesis, but diminished cells; by contrast,...
Abstract Immune checkpoint inhibitors have revolutionized the treatment of early and advanced cancer. Especially combination anti-cytotoxic T lymphocyte associated antigen 4 (CTLA-4) antibody anti-programmed death-1 (PD-1) antibody, has shown remarkable efficacy against various cancers approved for 7 indications by US FDA. However, there are still limitations with regard to response rates dose-dependent immune related adverse events (irAEs) caused CTLA-4 fully achieve optimal therapeutic...
Triple-negative breast cancer (TNBC) is highly metastatic and lethal. Due to a lack of druggable targets for this disease, there are no effective therapies in the clinic.We used TNBC cells xenografted mice as models explore triptonide-mediated inhibition metastasis tumor growth. Colony formation assay was quantify tumorigenesis cells. Wound-healing cell trans-well assays were utilized measure migration invasion. Tube applied access cell-mediated vasculogenic mimicry. Western blot,...
The transketolase 1 gene (TKTL1) is an essential factor that contributes to brain development. Some studies have shown the influence of TKTL1 in cancers, but it has been rarely reported kidney cancer. Furthermore, role prognosis and tumor infiltration immune cells various particularly cancer, remains unknown. In this study, expression its clinical characteristics were investigated using a variety databases. TIMER was used investigate relationship between infiltrates types We also studied...
Aims: Clinical studies showed that the use of probiotics during critical illness reduced nosocomial infection and improved clinical outcome. However, functional mechanisms is remains unclear. Therefore aim current study to explore protective effects understand underlying for beneficial live combined Bacillus subtilis Enterococcus faecium (LCBE) in cecal ligation puncture (CLP)-induced sepsis. Methods Results: Seven-week-old C57BL/6J mice were divided into three groups: sham group (6 mice),...
Salvador homolog-1 (SAV1) is a tumor suppressor required for activation of the tumor-suppressive Hippo pathway and inhibition tumorigenesis. SAV1 defective in several cancer types. deficiency cells promotes tumorigenesis metastasis, closely associated with poor prognosis patients. However, investigation therapeutic strategies to target lacking. Here we found that small molecule lycorine notably increased levels lung by inhibiting degradation via ubiquitin-lysosome system, inducing...
In the pathogenesis of rheumatoid arthritis (RA), fibroblast-like synoviocytes (RA-FLS) have tumor-like characteristics, mainly manifested by hyperproliferation and resistance to apoptosis then it will erode bone cartilage, eventually leading joint destruction. Paris saponin VII (PS VII) is an active compound derived from a traditional herbal medicine named Trillium tschonoskii Maxim, which has anti-tumor, analgesic, immunomodulatory effects. However, its anti-RA effect not yet been...
Compound Longmaining (CLMN) decoction, a herbal formula from Traditional Chinese Medicine (TCM), has been widely used for the treatment of cardiovascular diseases, especially myocardial infarction (MI) in recent years. With limited knowledge mechanisms underlying therapeutic effect CLMN on MI, this study was to use Network Pharmacology-based approach together with mice MI model gain more insight such mechanisms. The outcomes showed that 37 active compounds were identified constituting and...
Expression of the tight junction-associated protein junctional adhesion molecule-A (JAM-A) is increased in sepsis, although significance this unknown. Here, we show that septic JAM-A -/- mice have gut permeability, yet paradoxically decreased bacteremia and systemic TNF IL-1β expression. Survival improved JAM-A-/- mice. However, intestine-specific deletion does not alter mortality, suggesting mortality benefit conferred lacking independent intestine. Septic numbers splenic CD44hiCD4+ T...
Abstract Acute fatty liver of pregnancy (AFLP) is a rare disease progressive hepatic insufficiency and secondary systemic complications that induce significant maternal risk. The application combining plasma exchange (PE) continuous hemodiafiltration (CHDF) novel concept for patients with AFLP. Since 2002, we have utilized the combination PE CHDF as adjunctive medical therapy 11 AFLP multiple organ dysfunction. Before initiation, four had signs symptoms encephalopathy, required ventilatory...
Overexpression of DNA methyltransferase 1 (DNMT1) has been detected in many cancers. Tobacco exposure is known to induce genetic and epigenetic changes the pathogenesis malignancy. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) an important carcinogen present tobacco smoke; however detailed molecular mechanism how NNK induces esophageal carcinogenesis still unclear. We found that DNMT1 was overexpressed ESCC tissues compared with paired non-cancerous tissues, overexpression being...