A5042537888- Parkinson's Disease Mechanisms and Treatments
- Restless Legs Syndrome Research
- Sleep and Wakefulness Research
- Physical Activity and Health
- Neurological disorders and treatments
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Attention Deficit Hyperactivity Disorder
- Sleep and related disorders
- Mental Health Research Topics
- Tuberculosis Research and Epidemiology
- Child and Adolescent Psychosocial and Emotional Development
- Mycobacterium research and diagnosis
- Eating Disorders and Behaviors
- Diagnosis and treatment of tuberculosis
- Bipolar Disorder and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genetic Neurodegenerative Diseases
- Pulmonary Hypertension Research and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Suicide and Self-Harm Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neurological and metabolic disorders
Guangzhou Medical University
2022-2025
Chinese University of Hong Kong
2020-2024
Ningxia Medical University
2024
Guangdong Provincial People's Hospital
2022
State Key Laboratory of Brain and Cognitive Science
2022
Guangdong Academy of Medical Sciences
2022
University of Hong Kong
2022
Tang Shiu Kin Hospital
2021
There is a growing interest in the role of timing daily behaviors improving health. However, little known about optimal physical activity to maximize health benefits. We perform cohort study 92,139 UK Biobank participants with valid accelerometer data and all-cause cause-specific mortality outcomes, comprising over 7 years median follow-up (638,825 person-years). Moderate-to-vigorous intensity (MVPA) at any time day associated lower risks for all-cause, cardiovascular disease, cancer...
Abstract The microbiota-gut-brain axis has been suggested to play an important role in Parkinson’s disease (PD). Here we performed a cross-sectional study profile gut microbiota across early PD, REM sleep behavior disorder (RBD), first-degree relatives of RBD (RBD-FDR), and healthy controls, which could reflect the gut-brain staging model PD. We show compositions are significantly altered PD compared with control RBD-FDR. Depletion butyrate-producing bacteria enrichment pro-inflammatory...
Objective To investigate the prevalence and clinical correlates of video polysomnography (vPSG)-confirmed rapid eye movement sleep behaviour disorder (RBD) in patients with major depressive (MDD). Methods This is a clinic-based two-phase epidemiological study. In phase 1, MDD were screened by validated questionnaire, RBD Questionnaire-Hong Kong (RBDQ-HK). 2, subsample both screen-positive (RBDQ-HK >20) screen–negative underwent further assessment (vPSG) to confirm diagnosis (MDD+RBD)....
<h3>Background and Objectives</h3> Individuals with a history of recurrent dream-enactment behaviors, but subthreshold REM sleep without atonia levels for behavior disorder (RBD) diagnosis, are currently classified to have prodromal RBD (pRBD). However, the sleep–elevated EMG diagnostic cutoff, progression trajectory, long-term neurodegenerative outcome pRBD not well understood. This study aimed delineate evolution levels, determine cutoff score diagnosing pRBD, examine risk diseases pRBD....
Objective The purpose of this study was to investigate the differences in actigraphy‐measured rest‐activity patterns (eg, sleep–wake cycle, circadian rhythm, and physical activity) across different stages α‐synucleinopathy. Methods We compared alterations 7‐day among patients with clinically diagnosed α‐synucleinopathies (n = 44), their age‐, sex‐, body mass index (BMI)‐matched idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD, n 88), non‐rapid (RBD) controls 44) a...
Rapid eye movement (REM) sleep behaviour disorder (RBD) is one of the earliest and most specific prodromes α-synucleinopathies including Parkinson's disease (PD). It remains uncertain whether RBD occurring in context psychiatric disorders (psy-RBD), although very common, merely a benign epiphenomenon antidepressant treatment, or it harbours an underlying α-synucleinopathy. We hypothesised that patients with psy-RBD demonstrate familial predisposition to α-synucleinopathy.In this...
Background Understanding the evolution of circadian rhythm dysfunction and psychopathology in high-risk population has important implications for prevention bipolar disorder. Nevertheless, some previous studies on emergence psychopathologies among populations were inconsistent limited. Aims To examine prevalence rates sleep dysfunctions, mental disorders their symptoms offspring parents with (O-BD) without disorder (O-control). Methods The study included 191 O-BD 202 O-control subjects aged...
Summary Recurrent dream‐enactment behaviours (DEB) and rapid eye movement (REM) sleep without atonia (RSWA) are two diagnostic hallmarks of REM behaviour disorder (RBD), a specific prodrome α‐synucleinopathy. Whilst isolated RSWA (without DEB) was suggested as RBD, the implication ‘isolated’ recurrent DEB remains under‐investigated. In this cross‐sectional study, we sought to investigate neurodegenerative markers amongst first‐degree relatives (FDRs, aged >40 years) patients with RBD who...
Abstract Background The risk of neurodegenerative disorders in idiopathic rapid eye movement sleep behavior disorder (iRBD) patients with residual injurious symptoms (RIS) after symptomatic treatment clonazepam and/or melatonin is unclear. Objective objective this study was to determine the rate and correlates RIS its association diseases iRBD. Methods This a retrospective cohort study. defined by RBD Questionnaire–Hong Kong (RBDQ‐HK) as presence sleep‐related injuries or potential behaviors...
Abstract Patients with Parkinson’s disease (PD) were described less extraverted and more neurotic. It remained unclear whether similar personality traits could be found in idiopathic rapid eye movement sleep behavior disorder (iRBD), a prodromal stage of PD, predict phenoconversion to neurodegenerative disorders. We aimed investigate the profile its association future iRBD patients. One hundred eighty-five video-polysomnography confirmed patients 91 age- sex-matched controls underwent...
The relationship between lung function and cardiovascular disease (CVD) has emerged as a significant research focus in recent years, but studies on the effects of both forced expiratory volume 1 second (FEV1) vital capacity (FVC) remain limited. Among 29,662 participants UK Biobank study free CVD, rapid decline was defined either FEV1 (greatest quartile), FVC or (when exceeded greatest quartile). CVDs include coronary heart (CHD), arrhythmias, failure (HF), peripheral arterial (PAD), other...
Abstract Study objectives We aimed to investigate the prospective associations of sleep phenotypes with severe intentional self-harm (ISH) in middle-aged and older adults. Methods A total 499,159 participants (mean age: 56.55 ± 8.09 years; female: 54.4%) were recruited from UK Biobank between 2006 2010 follow-up until February 2016 this population-based study. Severe ISH was based on hospital inpatient records or a death cause ICD-10 codes X60-X84. Patients hospitalized diagnosis before...
Abstract Introduction Previous evidence suggested that the alteration of rest-activity pattern occurred in patients with isolated rapid eye movement behavior disorder (iRBD), a prodromal stage α-synucleinopathy implication to future phenoconversion. Nonetheless, it remains unclear whether this has already emerged RBD, and would be related conversion iRBD into parkinsonism-first or dementia-first subtype α-synucleinopathy. Methods We performed 1) case-control study compare measured by 7-day...
Objective While isolated rapid eye movement sleep behaviour disorder (iRBD) is known as a prodrome of α-synucleinopathies, the prediction for its future phenoconversion to parkinsonism-first or dementia-first subtype remains challenge. This study aimed investigate whether visuospatial dysfunction predicts in iRBD. Methods Patients with iRBD and control subjects were enrolled this prospective cohort study. Baseline neuropsychological assessment included Unified Parkinson’s Disease Rating...
Objective To determine multidimensional impulsivity levels across different early stages of α‐synucleinopathy. Methods This cross‐sectional study investigated motor and decisional using a panel computerized tasks among drug‐naïve parkinsonism patients, isolated/idiopathic rapid eye movement sleep behavior disorder (iRBD) patients their first‐degree relatives (iRBD‐FDRs), control participants. Trait impulse behaviors were assessed by self‐reported questionnaires. Results A total 27 157 iRBD...
Abstract Introduction Idiopathic/isolated REM sleep behavior disorder (iRBD) is regarded as the most specific prodromal stage of ⍺-synucleinopathies including Parkinson’s disease (PD). Striatal dopamine dysfunction a pathological hallmark in PD, which has been similarly reported iRBD sensitive marker for detecting early ⍺-synucleinopathies. In contrary, although there broad consensus that patients with PD have striatal volumes reduction, studies are relatively scarce and inconsistent. this...
Abstract Introduction Increased impulsivity is a common neuropsychiatric feature in patients with Parkinson’s disease (PD), especially attributed to the use of dopaminergic medications. Interestingly, emerging evidence suggested that had changed drug-naïve PD patients. However, it remains unclear whether has been altered prodromal stage PD, namely isolated rapid eye movement sleep behavior disorder (iRBD) and their high-risk relatives. Methods This was cross-sectional study four groups...