A5100720929- Sleep and related disorders
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Restless Legs Syndrome Research
- Parkinson's Disease Mechanisms and Treatments
- Obstructive Sleep Apnea Research
- Obesity, Physical Activity, Diet
- Sleep and Work-Related Fatigue
- Youth Substance Use and School Attendance
- Health disparities and outcomes
- Neuroscience of respiration and sleep
- Physical Activity and Health
- Mental Health Research Topics
- COVID-19 and Mental Health
- Child Nutrition and Feeding Issues
- Nutritional Studies and Diet
- Genetic Associations and Epidemiology
- Asthma and respiratory diseases
- Liver Disease Diagnosis and Treatment
- Cardiac Health and Mental Health
- Child and Adolescent Psychosocial and Emotional Development
- Psychological and Temporal Perspectives Research
- Health and Wellbeing Research
- Bipolar Disorder and Treatment
- Neurological disorders and treatments
Chinese University of Hong Kong
2016-2025
Guangzhou Medical University
2010-2025
Jinan University
2021-2025
China National Pharmaceutical Group Corporation (China)
2024
Southern Medical University
2021-2023
Guangdong Academy of Medical Sciences
2020-2023
Guangdong Provincial People's Hospital
2020-2023
Key Laboratory of Guangdong Province
2023
Guangdong General Hospital
2021-2023
Ministry of Education of the People's Republic of China
2023
Objective: The outbreak of the 2019 novel coronavirus disease (COVID-19) caused not only extraordinary public health concerns but also tremendous psychological distress, particularly among medical staff. We aimed to investigate prevalence rate insomnia and confirm related social factors staff in hospitals during COVID-19 outbreak. Method: Medical members China were recruited, including frontline workers. questionnaire, administered through WeChat program, obtained demographic data asked...
It is unclear whether there an association between chronotype and nonremission of depression, the related to confounding effect insomnia.A cohort patients with major depressive disorder were assessed for (by Morningness-Eveningness Questinnaire [MEQ]), symptoms, insomnia severity clinical outcomes in a naturalistic follow-up study.Of 253 recruited subjects (age 50.8 ± 10.2 y; female: 82.6%; response rate 90.0%), 19.4%, 56.1% 24.5% classified as eveningness, intermediate, morningness,...
Observational studies have suggested strong associations between sleep duration and many cardiovascular diseases (CVDs), but causal inferences not been confirmed. We aimed to determine the genetically predicted 12 CVDs using both linear nonlinear Mendelian randomization (MR) designs.Genetic variants associated with continuous, short (≤6 h) long (≥9 durations were used examine among 404 044 UK Biobank participants of White British ancestry. Linear MR analyses showed that was negatively...
Biologic systems involved in the regulation of motor activity are intricately linked with other homeostatic such as sleep, feeding behavior, energy, and mood. Mobile monitoring technology (eg, actigraphy ecological momentary assessment devices) allows these multiple real time. However, most clinical studies mental disorders that use mobile devices have not focused on dynamic associations between systems.To examine directional among activity, mood, sleep using a community-identified sample,...
The aim of this study was to test whether current and past night shift work associated with incident atrial fibrillation (AF) association modified by genetic vulnerability. Its associations coronary heart disease (CHD), stroke, failure (HF) were measured as a secondary aim.This cohort included 283 657 participants in paid employment or self-employed without AF 276 009 free CHD, HF at baseline the UK Biobank. Current lifetime information obtained. Cox proportional hazard models used. Weighted...
There is a growing interest in the role of timing daily behaviors improving health. However, little known about optimal physical activity to maximize health benefits. We perform cohort study 92,139 UK Biobank participants with valid accelerometer data and all-cause cause-specific mortality outcomes, comprising over 7 years median follow-up (638,825 person-years). Moderate-to-vigorous intensity (MVPA) at any time day associated lower risks for all-cause, cardiovascular disease, cancer...
Abstract The microbiota-gut-brain axis has been suggested to play an important role in Parkinson’s disease (PD). Here we performed a cross-sectional study profile gut microbiota across early PD, REM sleep behavior disorder (RBD), first-degree relatives of RBD (RBD-FDR), and healthy controls, which could reflect the gut-brain staging model PD. We show compositions are significantly altered PD compared with control RBD-FDR. Depletion butyrate-producing bacteria enrichment pro-inflammatory...
Abstract Aims To investigate the joint association of accelerometer-measured physical activity (PA) and sleep duration with mortality risk. Methods results A 7-day accelerometer recording was performed on 92 221 participants (age 62.4 ± 7.8 years; 56.4% women) from UK Biobank between February 2013 December 2015. We divided into three groups (short, normal, long), total volume PA levels according to tertiles (high, intermediate, low), moderate-to-vigorous (MVPA) two based World Health...
This study aimed to explore the moderation of pubertal status on onset sex differences in prevalence insomnia symptoms and their health correlates. A total 7,507 children adolescents (weighted percentage female: 48.5%) aged between 6–17 y were recruited from thirty-one primary secondary schools. Participants with difficulty initiating sleep (DIS), maintaining (DMS), and/or early morning awakening (EMA) ≥ 3 times/week past month considered as having symptoms. The severity was measured by...
A growing trend in childhood sleep habits is to compensate for the weekday deficit by longer weekend and holiday duration. We aimed investigate effect of weekend/holiday compensation relation overweight obesity.This a community-based cross-sectional study with 5159 children (49.6% boys), mean age 9.25 years (SD: 1.78), from 13 primary schools Hong Kong. Data on patterns, lifestyle, body weight, height were obtained questionnaires. Sleep durations during weekdays, weekends, holidays predictor...
a. Explore the stability in sleep/wake patterns of middle-aged adults over a 3-year follow-up period. b. relationship between objectively measured sleep indices, urinary catecholamines, and salivary cortisol.Naturalistic for (n = 114) by 2-week log cross-sectional design objective assessments hormonal measures 96) at period nearly 3 years after baseline measurements.CommunityHealthy adultsN/A.There were high correlations (2.6 ± 0.5 years) on (r 0.6-0.79) as log. For wave 2 study, poor...
To estimate the prevalence and health correlates of insomnia symptoms their association with comorbid mental disorders in a nationally representative sample adolescents United States.National cross-sectional study.Population-based from US adolescents.A total 6,483 individuals aged between 13–18 y National Comorbidity Survey-Adolescent Supplement (NCS-A) both individual parental reports were included this study. Participants classified if they reported difficulty initiating sleep, maintaining...
To determine the longitudinal associations of long-time mobile phone use (LTMPU) with sleep disturbances and mental distress in a prospective cohort technical college students. A total 4333 (response rate: 91.5%) 3396 78.4%) participants were recruited at baseline 8-month follow-up, respectively. Data collected by set questionnaires including socio-demographics, lifestyle practice, duration per day, patterns on weekdays weekends, as well Insomnia Severity Index, Epworth Sleepiness Scale,...
To evaluate the effectiveness of a multilevel and multimodal school-based education program.A cluster randomized controlled trial with 14 secondary schools in Hong Kong total 3713 students (intervention: 1545 vs control: 2168; 40.2% boys; mean age ± SD: 14.72 1.53 years) were included final analysis. The intervention town hall seminar, small class workshops, slogan competition, brochure, an educational Web site. Their parents teachers offered sleep seminars. control did not receive any...
Disrupted sleep is one of the prominent but often overlooked presenting symptoms in clinical course psychotic disorders. The aims this study were to examine prevalence disturbances, particularly insomnia and nightmares, their prospective associations with risk suicide attempts patients schizophrenia-spectrum disorders.A naturalistic longitudinal was conducted outpatients diagnosed disorders recruited from psychiatric outpatient clinic a regional university-affiliated public hospital Hong...