A5100435617- Heavy Metal Exposure and Toxicity
- Liver Disease Diagnosis and Treatment
- Birth, Development, and Health
- Vitamin D Research Studies
- Trace Elements in Health
- Diet, Metabolism, and Disease
- Thyroid Disorders and Treatments
- Genetic Associations and Epidemiology
- Diet and metabolism studies
- Hormonal and reproductive studies
- Effects and risks of endocrine disrupting chemicals
- Gout, Hyperuricemia, Uric Acid
- Power System Optimization and Stability
- Nutrition, Genetics, and Disease
- Health and Wellbeing Research
- Alcohol Consumption and Health Effects
- Gestational Diabetes Research and Management
- Obesity, Physical Activity, Diet
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Imaging and Diagnostics
- Nutrition and Health in Aging
- Bone and Joint Diseases
- Mental Health Research Topics
- Health and Well-being Studies
Hubei University of Medicine
2025
Tongji University
2022-2024
Tongji Hospital
2024
Nanjing Agricultural University
2023-2024
Shanghai University of Traditional Chinese Medicine
2012-2024
Shuguang Hospital
2012-2024
Fudan University
2024
Children's Hospital of Zhejiang University
2014-2024
Nanyang Normal University
2024
Asia University
2024
Abstract Background and aims Obesity, especially abdominal obesity, has been considered a risk factor for diabetic complications. Many obesity indices have established, including neck circumference (NC), waist-to-hip ratio (WHR), lipid accumulation product (LAP), visceral adiposity index (VAI) the Chinese (CVAI). However, studies investigating associations between these complications are limited. The objective of this study was to investigate with cardiovascular cerebrovascular disease...
The aim of this study was to test whether current and past night shift work associated with incident atrial fibrillation (AF) association modified by genetic vulnerability. Its associations coronary heart disease (CHD), stroke, failure (HF) were measured as a secondary aim.This cohort included 283 657 participants in paid employment or self-employed without AF 276 009 free CHD, HF at baseline the UK Biobank. Current lifetime information obtained. Cox proportional hazard models used. Weighted...
The Chinese were afflicted by great famine between 1959 and 1962. These people then experienced rapid economic development during which the gross domestic product per capita increased from $28 in 1978 to $6807 2013. We hypothesize that these two events are associated with booming rate of diabetes China.We aimed explore whether exposure early life high status adulthood was later life.Our data 6897 adults a cross-sectional Survey on Prevalence East China for Metabolic Diseases Risk Factors...
Lead (Pb) has been suggested as an endocrine-disrupting chemical. However, few studies have investigated the association between chronic Pb exposure and fatty liver disease.We aimed to investigate of with disease whether variations gut microbiota involve in mechanism induced by exposure.We conducted a cross-sectional study 3066 rural participants East China. Blood lead level (BLL) was detected, abdominal ultrasonography used diagnose hepatic steatosis. Both definition non-alcoholic (NAFLD)...
Atrial fibrillation (AF) is the most common sustained arrhythmia in adults. Investigations of risk factor profiles for AF according to age and genetic groups are essential promote individualized strategies prevention control AF.A total 409 661 participants (mean age, 56 years; 46% men) free at baseline with complete information about factors were included from UK Biobank cohort. The hazard ratios population-attributable (PAR) percentages incident associated 23 examined, including 3 social...
No study explores the association between follicle-stimulating hormone (FSH) and glucose metabolism in general women. We aim to investigate whether variation of FSH is associated with prediabetes diabetes postmenopausal Our data were from survey on prevalence East China for metabolic diseases risk factors 2014. Thousand six hundred ten women at age 55–89 who not using replacement therapy selected. Prediabetes defined according American Diabetes Association 2014 criteria. FSH, luteinizing...
Abstract We aimed to report environmental and blood lead level (BLL) in China investigate the relationship of BLL with body mass index (BMI) obesity. 5558 subjects were enrolled from 16 sites China. was measured by atomic absorption spectrometry. Obesity defined as BMI ≥ 30 kg/m 2 . Median (interquartile range) 44.00 μg/L (29.00–62.16) for men 37.79 (25.13–54.35) women, about twice higher than U.S. population. Subjects rural high-economic-status areas had significantly greater ( P <...
We aimed to evaluate trends in bone mineral density (BMD) and the prevalence of osteoporosis/osteopenia U.S. adults with prediabetes normal glucose regulation (NGR) further investigate association among prediabetes, osteopenia/osteoporosis, fracture.We collected analyzed data from National Health Nutrition Examination Surveys during period 2005 2014. Femoral neck lumbar spine BMD were available for 5,310 5,162 NGR >40 years old.A shift was observed toward a lower higher...
Abstract Background: Non-communicable chronic diseases have become the leading causes of disease burden worldwide. The trends and “metabolic associated fatty liver disease” (MAFLD) are unknown. We aimed to investigate cardiovascular renal burdens in adults with MAFLD non-alcoholic (NAFLD). Methods: Nationally representative data were analyzed including from 19,617 non-pregnant aged ≥20 years cross-sectional US National Health Nutrition Examination Survey periods, 1999 2002, 2003 2006, 2007...
The fat-to-muscle mass ratio (FMR) might be an indicator to assess type 2 diabetes risk independent of general obesity. However, no longitudinal studies have explored the extent which total and regional FMRs may confer risks. We aimed measure sex-specific associations between arm, leg, trunk whole body incident diabetes.A 464 817 participants (207 286 men 257 531 women, mean age 56.5 ± 8.2 56.2 8.0 years old, respectively) free at baseline were included in this prospective cohort study with...
Abstract Background Limited studies have explored the association between visceral adipose tissue (VAT) mass and fat‐to‐muscle ratio (FMR) mortality. We aimed to evaluate sex‐specific of VAT FMR with all‐cause cause‐specific mortality by age. Methods A total 438 896 participants (49.8% men, mean age ± standard deviation: 57 8 years for men; 56 women) were included from UK Biobank cohort. The nature was predictive, as obtained sex‐stratified, non‐linear prediction models. Fat muscle estimated...
Unhealthy sleep behaviors may be potential risk factors for chronic kidney disease (CKD). We aimed to examine the associations of combined patterns and genetic susceptibility with incident CKD.This large-scale prospective cohort study included 370,671 participants without CKD at baseline (2006-2010) in UK Biobank data. Five were made up duration, insomnia, snoring, chronotype, daytime sleepiness according questionnaire. Overall by summing five scores created. Weighted score function was...
Abstract Background: Life's Simple 7, the former construct of cardiovascular health (CVH) has been used to evaluate adverse non-communicable chronic diseases (NCDs). However, some flaws have recognized in recent years and Essential 8 established. In this study, we aimed analyze association between CVH defined by risk 44 common NCDs further estimate population attributable fractions (PAFs) low-moderate scores NCDs. Methods: UK Biobank, 170,726 participants free at baseline were included. The...
Cardiovascular disease is the leading cause of mortality in postmenopausal women. Follicle-stimulating hormone (FSH) shows negative associations with obesity and diabetes mellitus We aimed to study between FSH 10-year risk atherosclerotic cardiovascular (ASCVD) women.SPECT-China (the Survey on Prevalence East China for Metabolic Diseases Risk Factors) a 22-site, population-based conducted during 2014-2015. This included 2658 A newly developed effective tool ASCVD prediction among Chinese was...
China has undergone rapid urbanization in the past three decades. We aimed to report blood lead level (B-Pb) most rapidly urbanized Yangtze River Delta Region of China, and explore association B-Pb non-alcoholic fatty liver disease (NAFLD). Our data source was SPECT-China study. enrolled 2011 subjects from 6 villages Region. Lead measured by atomic absorption spectrometry. According abdominal ultrasound, residents were divided into normal NAFLD groups. In total, 824 (41.0%) diagnosed with...
Highlights•The causality between vitamin D and NAFLD was controversial in human beings.•Using mendelian randomization analysis, 25(OH)D are not causally associated.•Long-term deficiency may affect the development of NAFLD.AbstractBackgroundVitamin is associated with nonalcoholic fatty liver disease (NAFLD) many cross-sectional studies. However, them has been established. We used bi-directional (MR) analysis to explore causal relationship 25-hydroxyvitamin [25(OH)D] NAFLD.Methods9182...
Previous studies have revealed the association of lead (Pb) exposure with obesity. DNA methylation alteration has been suggested to be one regulatory mechanisms We aimed explore whether Pb is related weight gain and alteration.Male adult 8 week Wistar rats were divided into 5 groups: normal chow diet (NCD); NCD+0.05%Pb; NCD+0.15%Pb; NCD+0.45%Pb high fat diet. Rats exposed different dosages through drinking water for 21 weeks. Body weight, fasted blood glucose level, insulin homeostasis...
Few studies have investigated the association between serum uric acid (UA) and cadmium exposure. Our previous study revealed a significantly higher blood (CdB) level in Chinese population compared to populations other countries. To determine whether CdB adults is associated with UA hyperuricemia, 2996 participants from cross-sectional SPECT-China were recruited. was measured by atomic absorption spectrometry. Hyperuricemia defined as concentration ≥416.4 μmol/L for men ≥356.9 women....
The alanine aminotransferase (ALT)/aspartate (AST) ratio is reportedly associated with insulin resistance (IR). However, few studies have explored the relationship between ALT/AST and IR in Chinese population. Here, we aimed to explore whether and, if so, what extent, population as categorized by waist circumference (WC). Our data were obtained from SPECT-China study, a cross-sectional survey on prevalence of metabolic diseases risk factors East China 2014 2015. A total 8398 participants...