Abstract Background and aims Obesity, especially abdominal obesity, has been considered a risk factor for diabetic complications. Many obesity indices have established, including neck circumference (NC), waist-to-hip ratio (WHR), lipid accumulation product (LAP), visceral adiposity index (VAI) the Chinese (CVAI). However, studies investigating associations between these complications are limited. The objective of this study was to investigate with cardiovascular cerebrovascular disease...

The aim of this study was to test whether current and past night shift work associated with incident atrial fibrillation (AF) association modified by genetic vulnerability. Its associations coronary heart disease (CHD), stroke, failure (HF) were measured as a secondary aim.This cohort included 283 657 participants in paid employment or self-employed without AF 276 009 free CHD, HF at baseline the UK Biobank. Current lifetime information obtained. Cox proportional hazard models used. Weighted...

Lead (Pb) has been suggested as an endocrine-disrupting chemical. However, few studies have investigated the association between chronic Pb exposure and fatty liver disease.We aimed to investigate of with disease whether variations gut microbiota involve in mechanism induced by exposure.We conducted a cross-sectional study 3066 rural participants East China. Blood lead level (BLL) was detected, abdominal ultrasonography used diagnose hepatic steatosis. Both definition non-alcoholic (NAFLD)...

Atrial fibrillation (AF) is the most common sustained arrhythmia in adults. Investigations of risk factor profiles for AF according to age and genetic groups are essential promote individualized strategies prevention control AF.A total 409 661 participants (mean age, 56 years; 46% men) free at baseline with complete information about factors were included from UK Biobank cohort. The hazard ratios population-attributable (PAR) percentages incident associated 23 examined, including 3 social...

We aimed to evaluate trends in bone mineral density (BMD) and the prevalence of osteoporosis/osteopenia U.S. adults with prediabetes normal glucose regulation (NGR) further investigate association among prediabetes, osteopenia/osteoporosis, fracture.We collected analyzed data from National Health Nutrition Examination Surveys during period 2005 2014. Femoral neck lumbar spine BMD were available for 5,310 5,162 NGR >40 years old.A shift was observed toward a lower higher...

Abstract Background: Non-communicable chronic diseases have become the leading causes of disease burden worldwide. The trends and “metabolic associated fatty liver disease” (MAFLD) are unknown. We aimed to investigate cardiovascular renal burdens in adults with MAFLD non-alcoholic (NAFLD). Methods: Nationally representative data were analyzed including from 19,617 non-pregnant aged ≥20 years cross-sectional US National Health Nutrition Examination Survey periods, 1999 2002, 2003 2006, 2007...

The fat-to-muscle mass ratio (FMR) might be an indicator to assess type 2 diabetes risk independent of general obesity. However, no longitudinal studies have explored the extent which total and regional FMRs may confer risks. We aimed measure sex-specific associations between arm, leg, trunk whole body incident diabetes.A 464 817 participants (207 286 men 257 531 women, mean age 56.5 ± 8.2 56.2 8.0 years old, respectively) free at baseline were included in this prospective cohort study with...

Abstract Background Limited studies have explored the association between visceral adipose tissue (VAT) mass and fat‐to‐muscle ratio (FMR) mortality. We aimed to evaluate sex‐specific of VAT FMR with all‐cause cause‐specific mortality by age. Methods A total 438 896 participants (49.8% men, mean age ± standard deviation: 57 8 years for men; 56 women) were included from UK Biobank cohort. The nature was predictive, as obtained sex‐stratified, non‐linear prediction models. Fat muscle estimated...

Unhealthy sleep behaviors may be potential risk factors for chronic kidney disease (CKD). We aimed to examine the associations of combined patterns and genetic susceptibility with incident CKD.This large-scale prospective cohort study included 370,671 participants without CKD at baseline (2006-2010) in UK Biobank data. Five were made up duration, insomnia, snoring, chronotype, daytime sleepiness according questionnaire. Overall by summing five scores created. Weighted score function was...

Obstructive sleep apnea (OSA) is a common chronic disease with various comorbidities. The cardiometabolic index (CMI) reflects visceral fat tissue distribution and function, assessing the risk of obesity-related conditions such as metabolic syndrome (MetS) stroke, which are strongly connected to OSA. relationship between CMI OSA combined MetS (OMS) remains unclear. This study aims evaluate screening value for OMS, compared lipid accumulation product (LAP). A total 280 participants who...

Bladder cancer is characterized by aberrant activation of the phosphatidylinositol-3-OH kinase (PI3K) signaling, underscoring significance directing therapeutic efforts toward PI3K pathway as a promising strategy. In this study, we discovered that serves potent target for bladder through high-throughput screening inhibitory molecules. The inhibitor demonstrated robust anti-tumor efficacy, validated both in vitro and vivo settings. Nevertheless, feedback JAK1-STAT3 signaling reinstated cell...

Whether or not there is targeted pharmacotherapy for dementia, an active and healthy lifestyle that includes physical activity (PA) may be a better option than medication preventing dementia. We examined the association between leisure-time sedentary behavior (SB) risk of dementia incidence mortality. further quantified effect on replacing time with equal amount spent different activities. In UK Biobank, 484,169 participants (mean age = 56.5 years; 45.2% men) free were followed from baseline...

Background/Purpose Metabolic associated fatty liver disease (MAFLD) was proposed as a new definition to put emphasis on the metabolic aspects of nonalcoholic (NAFLD). We aim compare cardiovascular and renal burden between MAFLD NAFLD patients. Methods 12183 participants were enrolled in East China. The (Framingham risk score previous diseases (CVD)) (eGFR chronic kidney (CKD)) measured. Results hypertension, dyslipidemia, diabetes, overweight/obesity, central obesity patients higher than...

Background Corticospinal tract (CST) is the principal motor pathway; we aim to explore structural plasticity mechanism in CST during stroke rehabilitation. Methods A total of 25 patients underwent diffusion tensor imaging before rehabilitation (T1), 1-month post-rehabilitation (T2), 2 months (T3), and 1-year post-discharge (T4). The was segmented, fractional anisotropy (FA), axial (AD), mean diffusivity (MD), radial (RD) were determined using automated fiber quantification tractography....

ABSTRACT Background The thalamus plays a pivotal role in functional brain networks, yet its contribution to motor function recovery following stroke remains elusive. We aim explore changes thalamocortical connectivity poststroke and correlation with function. Methods Thirty‐nine subacute ischemic patients 32 healthy individuals underwent resting‐state magnetic resonance imaging (MRI). Fugl–Meyer Assessment (FMA) was employed evaluate upper lower extremity before 1 year after rehabilitation....

The development of antibacterial sponges with both high water-absorbing and mechanical properties is highly desirable for attaining efficient hemostasis closure noncompressible wounds, but remains challenging. General methods, such as increasing porosity, to improve the water absorption inevitably compromise their properties. Herein, a chitin (CT)/quaternized chitosan (QCS) sponge was fabricated by freeze-drying chemically physically dual cross-linked CT/QCS hydrogel enhanced hydrophilicity....

Abstract Renal tubular epithelial cell injury is a significant factor in the formation of kidney stones. However, regulatory mechanisms behind this injury, especially association with autophagy‐mediated ferroptosis, remain unclear. This study first identified upregulated ferroptosis related gene ChaC Glutathione Specific Gamma‐Glutamylcyclotransferase 1 (CHAC1) stone samples through bioinformatics analysis. Subsequently, damage model established by treating renal cells (HK‐2) calcium oxalate...

BACKGROUND: Rehabilitation is an efficacious method to improve poststroke motor dysfunction. Various rehabilitative techniques have become popular in this field of research. However, it has not been reported whether better outcomes can be achieved if rehabilitation training conducted at the optimal time day. METHODS: A model photothrombotic ischemic stroke was used C57/BL6 mice, and 24-hour activity cycles were evaluated. We found peak around Zeitgeber (ZT)13 (21:00) a trough ZT20 (04:00)...

Background and purpose The ideal stroke classification system needs to have validity, high reliability applicability among different research settings. Chinese Ischemic Stroke Subclassification (CISS) the Subtypes of Classification System (SPARKLE) emerged recently but not been tested using agreement analysis. As a result, objective this study is investigate level subtype classifications CISS, SPARKLE Trial Org 10172 in Acute Treatment (TOAST). We also analyse inter-rater CISS. Methods data...

Background Antibody-mediated rejection (AMR) occupies a major position for chronic after kidney transplantation. Regulatory B cell (Breg) has been reported to have an inhibitory immune function, which contributes the resistance AMR. Methods A nested case–control study nine healthy donors, 25 stable (ST) patients, and 18 AMR patients was performed determine type of Breg in maintaining tolerance preventing Results Compared ST group, circulating interleukin (IL)-10 + Bregs, but not...

Abstract Background and Aim Non‐alcoholic fatty liver disease (NAFLD) is associated with incident type 2 diabetes; however, the extent to which NAFLD may confer its risk remains uncertain, especially in Europeans. Emerging evidence suggests that sleep behaviors are linked diabetes. We aimed measure whether modified association between Methods This prospective cohort study included 365 339 participants without diabetes at baseline UK Biobank data. Five behaviors, including duration, insomnia,...