A5085467745- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Hormonal and reproductive studies
- Vitamin D Research Studies
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Heavy Metal Exposure and Toxicity
- Metabolism, Diabetes, and Cancer
- Gout, Hyperuricemia, Uric Acid
- Birth, Development, and Health
- Thyroid Disorders and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- High Altitude and Hypoxia
- Advanced MRI Techniques and Applications
- Genetic Associations and Epidemiology
- Diabetes Treatment and Management
- Sexual Differentiation and Disorders
- Nutritional Studies and Diet
- Cancer, Hypoxia, and Metabolism
- Trace Elements in Health
- Adipokines, Inflammation, and Metabolic Diseases
- Bone health and osteoporosis research
- Cardiovascular Disease and Adiposity
- Chronic Disease Management Strategies
- Effects and risks of endocrine disrupting chemicals
Shanghai Ninth People's Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
China Institute of Sport Science
2012-2025
Dalian Maritime University
2023-2025
Zhejiang University
2000-2024
Uppsala University
2024
Creative Commons
2023
Max Planck Institute for Metabolism Research
2023
Guangdong Provincial People's Hospital
2022
New York Institute of Technology
2021
The motivation of the segmentation challenge is to quantitatively analyze global and regional cardiac function from cine magnetic resonance (MR) images, clinical parameters such as ejection fraction (EF), left ventricle myocardium mass (MM), stroke volume (SV) are required. Calculations these depend upon accurate delineation endocardial epicardial contours (LV). Manual time-consuming tedious has high inter-observer variability. Thus, fully automatic LV desirable. in MR typically faces four...
Abstract Background and aims Obesity, especially abdominal obesity, has been considered a risk factor for diabetic complications. Many obesity indices have established, including neck circumference (NC), waist-to-hip ratio (WHR), lipid accumulation product (LAP), visceral adiposity index (VAI) the Chinese (CVAI). However, studies investigating associations between these complications are limited. The objective of this study was to investigate with cardiovascular cerebrovascular disease...
The aim of this study was to test whether current and past night shift work associated with incident atrial fibrillation (AF) association modified by genetic vulnerability. Its associations coronary heart disease (CHD), stroke, failure (HF) were measured as a secondary aim.This cohort included 283 657 participants in paid employment or self-employed without AF 276 009 free CHD, HF at baseline the UK Biobank. Current lifetime information obtained. Cox proportional hazard models used. Weighted...
Late Gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) imaging can be used to visualise regions of fibrosis and scarring in the left atrium (LA) myocardium. This important for treatment stratification patients with atrial fibrillation (AF) assessment after radio frequency catheter ablation (RFCA). In this paper we present a standardised evaluation benchmarking framework algorithms segmenting scar from LGE CMR images. The reported are response an open challenge that was put...
Background & aimsEpidemiologic studies have revealed that early-life conditions influence later risk of chronic diseases. We aimed to explore whether exposure Chinese famine between 1959 and 1962 during fetal childhood period was related with metabolic syndrome (MS) in adulthood.Methods6445 subjects from SPECT-China study were divided into fetal-exposed (1959–1962), childhood-exposed (1949–1958), adolescence/young adult-exposed (1921–1948), non-exposed (1963–1974) (after 1975). MS defined by...
In addition to improving glucose metabolism, liraglutide, a glucagon-like peptide-1 receptor agonist, has weight-loss effects. The underlying mechanisms are not completely understood. current study was performed explore whether liraglutide could lower weight by modulating the composition of gut microbiota in simple obese and diabetic rats. our study, Wistar Goto-Kakizaki (GK) rats were randomly treated with or normal saline for 12 weeks. biochemical parameters metabolic hormones measured....
It is now clear that insulin signaling has important roles in regulation of neuronal functions the brain. Dysregulation brain been linked to neurodegenerative disease, particularly Alzheimer's disease (AD). In this regard, there evidence improvement neuroprotective activity against amyloid β (Aβ)-induced neurotoxicity for patients with AD. Linagliptin an inhibitor dipeptidylpeptidase-4 (DPP-4), which improves impaired secretion and downstream peripheral tissues. However, whether protective...
The Chinese were afflicted by great famine between 1959 and 1962. These people then experienced rapid economic development during which the gross domestic product per capita increased from $28 in 1978 to $6807 2013. We hypothesize that these two events are associated with booming rate of diabetes China.We aimed explore whether exposure early life high status adulthood was later life.Our data 6897 adults a cross-sectional Survey on Prevalence East China for Metabolic Diseases Risk Factors...
Epidemiologic studies have indicated that early life nutrition influences later risk of obesity, type 2 diabetes, and metabolic syndrome. Nonalcoholic fatty liver disease (NAFLD) is also considered a disease.
The neutrophil-to-lymphocyte ratio (NLR) is an inexpensive and easily measurable laboratory index indicating systemic inflammation, while the application of many other inflammatory markers has been limited in daily clinical practice. However, large population studies about investigating associations NLR level with diabetic complications including cardiovascular cerebrovascular diseases (CVD), kidney disease (DKD), retinopathy (DR) same were limited. aim our study to evaluate between...
Lead (Pb) has been suggested as an endocrine-disrupting chemical. However, few studies have investigated the association between chronic Pb exposure and fatty liver disease.We aimed to investigate of with disease whether variations gut microbiota involve in mechanism induced by exposure.We conducted a cross-sectional study 3066 rural participants East China. Blood lead level (BLL) was detected, abdominal ultrasonography used diagnose hepatic steatosis. Both definition non-alcoholic (NAFLD)...
Atrial fibrillation (AF) is the most common sustained arrhythmia in adults. Investigations of risk factor profiles for AF according to age and genetic groups are essential promote individualized strategies prevention control AF.A total 409 661 participants (mean age, 56 years; 46% men) free at baseline with complete information about factors were included from UK Biobank cohort. The hazard ratios population-attributable (PAR) percentages incident associated 23 examined, including 3 social...
To evaluate the association of cardiovascular health (CVH), measured by Life's Essential 8 score, with risk premature mortality and to determine patterns CVH-related differences in life expectancy among people without type 2 diabetes (T2D).This prospective study included 309,789 participants (age 56.6 ± 8.1 years; 46% men) enroled UK Biobank. The composite measure consists four behaviours (diet, physical activity, nicotine exposure, sleep) factors (BMI, non-HDL cholesterol, blood glucose,...
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have shown promise in reducing the risk of atrial fibrillation (AF). However, results are controversial and underlying metabolic mechanism remains unclear. Emerging evidence implied that SGLT2 extra beneficial effects on circulating metabolites beyond glucose control, which might play a role AF. Hence, our study aimed to investigate effect mediating inhibition AF by Mendelian randomization (MR).A two-sample two-step MR was conducted evaluate...
BACKGROUND: An association between sweetened beverages and several cardiometabolic diseases has been reported, but their with atrial fibrillation (AF) is unclear. We aimed to investigate the associations consumption of sugar-sweetened (SSB), artificially (ASB), pure fruit juice (PJ) risk AF further evaluate whether genetic susceptibility modifies these associations. METHODS: A total 201 856 participants who were free baseline AF, had data available, completed a 24-hour diet questionnaire...
Cholesterol homeostasis is strictly regulated through the modulation of HMG-CoA reductase (HMGCR), rate-limiting enzyme cholesterol synthesis. Phosphorylation HMGCR inactivates it and dephosphorylation activates it. AMP-activated protein kinase (AMPK) major phosphorylating enzyme. Our previous study found that thyroid-stimulating hormone (TSH) increased hepatocytic expression, but was still unclear whether TSH affected hepatic phosphorylation associated with AMPK. We used bovine (bTSH) to...
MicroRNAs (miRNAs) are endogenous, noncoding, short, single-stranded RNAs that evolutionarily conserved and believed to play a role in controlling variety of biological processes. The roles miRNAs insulin resistance liver steatosis, however, largely unknown. objective this study was evaluate the miR-130a regulation sensitivity steatosis. In our current study, we observed overexpression miR-130a-3p increases signaling both HepG2 cells primary mouse hepatocytes, silencing has opposite effects....