A5011656472- Pancreatic function and diabetes
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Adsorption and Cooling Systems
- Chemical Looping and Thermochemical Processes
- Metabolism, Diabetes, and Cancer
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Diet and metabolism studies
- Gut microbiota and health
- MicroRNA in disease regulation
- Anesthesia and Pain Management
- Analytical chemistry methods development
- RNA modifications and cancer
- Phase Change Materials Research
- Cardiac Health and Mental Health
- Ferroptosis and cancer prognosis
- Fibroblast Growth Factor Research
- Diet, Metabolism, and Disease
- Nausea and vomiting management
- Regulation of Appetite and Obesity
- Thermal Expansion and Ionic Conductivity
- Helicobacter pylori-related gastroenterology studies
- Muscle Physiology and Disorders
Chengdu University of Traditional Chinese Medicine
2023-2025
First Affiliated Hospital of Chengdu Medical College
2021-2025
Changsha Central Hospital
2024
Zhejiang University
2021-2024
Central South University
2022-2024
University of South China
2024
Third Xiangya Hospital
2024
University of Chinese Academy of Sciences
2014-2023
Shanghai Institute of Nutrition and Health
2018-2023
Shanghai University
2020-2023
Gut microbiota plays important roles in health maintenance and diseases. Physical exercise has been demonstrated to be able modulate gut microbiota. However, the potential role of microbiome protection myocardial infarction (MI) remains unclear.Here, we discovered training ameliorated cardiac dysfunction changed microbial richness community structure post-MI. Moreover, pre-depletion abolished protective effects MI mice. Furthermore, mice receiving transplants from exercised had better...
MicroRNAs (miRNAs) are endogenous, noncoding, short, single-stranded RNAs that evolutionarily conserved and believed to play a role in controlling variety of biological processes. The roles miRNAs insulin resistance liver steatosis, however, largely unknown. objective this study was evaluate the miR-130a regulation sensitivity steatosis. In our current study, we observed overexpression miR-130a-3p increases signaling both HepG2 cells primary mouse hepatocytes, silencing has opposite effects....
Although the gluconeogenesis pathway is already a target for treatment of type 2 diabetes, potential role microRNAs (miRNAs) in remains unclear. Here, we investigated physiological functions miR-214 gluconeogenesis. The expression was suppressed by glucagon via protein kinase A signaling primary hepatocytes, and down-regulated livers fasted, high fat diet-induced diabetic leptin receptor-mutated (db/db) mice. overexpression hepatocytes glucose production, silencing reversed this effect....
The mechanisms underlying glucocorticoid (GC)-increased adiposity are poorly understood. Brown adipose tissue (BAT) acquires white (WAT) cell features defined as BAT whitening under certain circumstances. aim of our current study was to investigate the possibility and GC-induced whitening. Here, we showed that one-week dexamethasone (Dex) treatment induced whitening, characterized by lipid droplet accumulation, in vitro vivo. Furthermore, autophagy ATG7 (autophagy related 7) expression Dex,...
Exercise can protect myocardial infarction (MI) and downregulate cardiac Homeodomain-Interacting Protein Kinase 2 (HIPK2). However, the role of HIPK2 in MI is unclear.HIPK2-/- mice miR-222-/- rats, inhibitor (PKI1H) adeno-associated virus serotype 9 (AAV9) carrying miR-222 were applied study. Animals subjected to running, swimming, acute or post-MI remodeling. inhibition P53 activator used neonatal rat cardiomyocytes (NRCMs) human embryonic stem cell-derived (hESC-CMs) oxygen glucose...
Homeodomain-Interacting Protein Kinase 2 (HIPK2) has been reported to maintain basal cardiac function, however, its role in pathological remodeling remains unclear.HIPK2 inhibitors (tBID and PKI1H) treated mice two lines of HIPK2-/- were subjected transverse aortic constriction (TAC). HIPK2 knockdown performed neonatal rat cardiomyocytes (NRCMs), fibroblasts (NRCFs), human embryonic stem cell-derived (hESC-CMs). Microarray analysis was used screen targets. Overexpression early growth...
The application of immunotherapy in tumor, especially immune checkpoint inhibitors (ICIs), has played an important role the treatment advanced unresectable liver cancer. However, efficacy ICIs varies greatly among different patients, which aroused people’s attention to regulatory mechanism programmed death ligand-1 (PD-L1) escape PD-L1 is regulated by multiple levels and signaling pathways hepatocellular carcinoma (HCC), including gene variation, epigenetic inheritance, transcriptional...
Drug repurposing offers a valuable strategy for identifying new therapeutic applications existing drugs. Recently, disulfiram (DSF), drug primarily used alcohol addiction treatment, has emerged as potential treatment inflammatory diseases by inhibiting pyroptosis, form of programmed cell death. The activity DSF can be further enhanced the presence Cu
Abstract High‐temperature thermochemical energy storage based on metal oxides is the key technology to reducing levelized costs of electricity next‐generation concentrated solar power plants. CuO/Cu 2 O has wide availability and high density, but severe sintering leads low reactivity. In this study, an innovative approach modulate oxygen vacancy content change surface properties crystal structure enhance resistance redox reversibility proposed. The re‐oxidation degree increased from 46% 99%,...
Although numerous functions of extracellular signal-regulated kinase 1/2 (ERK1/2) are identified, a direct effect ERK1/2 on liver steatosis has not been reported. Here, we show that activity is compromised in livers leptin receptor-deficient (db/db) mice. Adenovirus-mediated activation mitogen-activated protein 1 (MEK1), the upstream regulator ERK1/2, significantly ameliorated db/db mice, increased expression genes related to fatty acid β-oxidation and triglyceride (TG) export serum...
Although many biological functions of MAPK1/ERK2-MAPK3/ERK1 (mitogen-activated protein kinase 1/3) have been reported, a direct effect MAPK1/3 on hepatic lipid metabolism remains largely unknown. We recently showed that activation ameliorates liver steatosis in LEPR (leptin receptor)-deficient (db/db) mice, classic animal model for steatosis. Consistent with these results, knockdown promotes C57/B6J wild-type (WT) mice. Autophagic flux and ATG7 (autophagy related 7) levels are increased by...
Liver steatosis, a condition in which lipid accumulates liver cells, is leading cause of many diseases. The livers patients with hepatocellular carcinoma, cancer characterized by have decreased abundance the transcription cofactor BTG1 (B cell translocation gene 1). We showed that db/db mice, are genetic model obesity, had mRNA and protein abundance. overexpression ameliorated steatosis whereas knockdown induced wild-type mice. Consistent these changes, we found triglyceride accumulation...
Although many functions of activating transcription factor 4 (ATF4) are identified, a role ATF4 in the hypothalamus regulating energy homeostasis is unknown. Here, we generated adult-onset agouti-related peptide neuron–specific knockout (AgRP-ATF4 KO) mice and found that these were lean, with improved insulin leptin sensitivity decreased hepatic lipid accumulation. Furthermore, AgRP-ATF4 KO showed reduced food intake increased expenditure, mainly because enhanced thermogenesis brown adipose...
Hepatocellular carcinoma (HCC) ranks as the fourth leading cause of cancer-related deaths in China, and treatment options are limited. The cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) activates stimulator interferon gene (STING) signaling pathway a crucial immune response cytoplasm, which detects cytoplasmic DNA to regulate innate adaptive responses. As potential therapeutic target, cGAS-STING markedly inhibits tumor cell proliferation metastasis, with its...
With the outbreak of Mpox in non-endemic countries May 2022, which has captured international attention. In response, this study leveraged real-time, predictive, and wide coverage advantages big data to reflect public's needs interests regarding epidemic, explore its potential early warning role. We carried out a systematic search weekly on two major network platforms-Baidu Search Index (BDI) WeChat (WCI) China, index overview, main concern information, hotspot regional distribution were...
Phosphoserine aminotransferase 1 (PSAT1) is an enzyme participating in serine synthesis. A role of PSAT1 the regulation insulin sensitivity, however, unknown. In this study, we showed that hepatic expression and liver levels are reduced genetically engineered leptin receptor–deficient (db/db) mice high-fat diet (HFD)–induced diabetic mice. Additionally, overexpression by adenovirus expressing improved signaling sensitivity vitro vivo under normal conditions. Opposite effects were observed...