A5100418777- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Lipid metabolism and disorders
- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Obstructive Sleep Apnea Research
- Cardiac pacing and defibrillation studies
- Heart Rate Variability and Autonomic Control
- Adipose Tissue and Metabolism
- Cardiac Health and Mental Health
- Heat shock proteins research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Fibrosis and Remodeling
- Cardiovascular Effects of Exercise
- Pericarditis and Cardiac Tamponade
- ECG Monitoring and Analysis
- Venous Thromboembolism Diagnosis and Management
- Medication Adherence and Compliance
- Sepsis Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Cardiomyopathy and Myosin Studies
- Cardiac Valve Diseases and Treatments
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2023-2024
Tianjin University of Traditional Chinese Medicine
2023-2024
Brigham and Women's Hospital
2014-2024
Harvard University
2023-2024
Liupanshui Normal University
2024
First Hospital of Qinhuangdao
2018-2023
People's Hospital of Shiyan
2023
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2012-2023
Wuhan University
2020-2023
Wuhan Asia Heart Hospital
2022-2023
Impairment in left ventricular systolic function has been described heart failure (HF) with preserved ejection fraction (HFpEF), but its prognostic relevance is not known. We determined whether longitudinal strain (LS) predictive of cardiovascular outcomes HFpEF beyond clinical and conventional echocardiographic measures.
Abstract Background Hesperidin, a natural flavanone, has been proven to have multiple protective effects in diabetic rats, such as antioxidant, anti-inflammatory and anti-apoptotic effects. However, the molecular mechanisms underlying of hesperidin are not well elucidated. Methods LO2 cells were stimulated with high glucose (HG, 33 mM) for 24 h establish model oxidative stress. Then, cell viability was determined using MTT assay. The antioxidant activities, including reactive oxygen species...
Homeodomain-Interacting Protein Kinase 2 (HIPK2) has been reported to maintain basal cardiac function, however, its role in pathological remodeling remains unclear.HIPK2 inhibitors (tBID and PKI1H) treated mice two lines of HIPK2-/- were subjected transverse aortic constriction (TAC). HIPK2 knockdown performed neonatal rat cardiomyocytes (NRCMs), fibroblasts (NRCFs), human embryonic stem cell-derived (hESC-CMs). Microarray analysis was used screen targets. Overexpression early growth...
Emerging evidence indicates that serum polyamines, including putrescine, spermidine, and spermine, may serve as potential biomarkers for chronic kidney disease (CKD) its progression. However, the association between polyamine levels, cardiovascular events, mortality in CKD patients remains poorly understood. A retrospective cohort study was conducted, involving 297 adult with at stages 1-5 from March 2015 to September 2018, follow-up until May 2023. Serum levels were quantified using...
Elevated cardiac triacylglycerol (TAG) content is traditionally equated with cardiolipotoxicity and suggested to be a culprit in dysfunction. However, previous work demonstrated that myosin heavy-chain–mediated cardiac-specific overexpression of diacylglycerol transferase 1 (MHC-DGAT1), the primary enzyme for TAG synthesis, preserved function two lipotoxic mouse models despite maintaining high content. Therefore, we examined whether increased cardiomyocyte levels due DGAT1 led changes...
Abstract Background Patients with heart failure frequently report inadequate self-care behaviours. Physical symptoms can impact patients’ ability to perform However, studies investigating the association between physical and behaviours have produced inconsistent findings, potentially due variations in determinants of among patients differing levels proficiency. Understanding could improve care for this subpopulation. The study aimed explore Chinese Methods This analysis was based on primary...
Background The de Winter electrocardiogram (EKG) pattern is a novel sign that indicates left anterior descending coronary artery (LAD) occlusion in patients with chest pain. This study aimed to assess the prevalence and clinical characteristics of this pattern. Hypothesis EKG an special ST‐segment elevation myocardial infarction (STEMI) equivalents without obvious elevation. Methods retrospective included all admitted between January 2011 December 2017. Patients were categorized into two...
Abstract Despite substantial breakthroughs in the treatment of hepatocellular carcinoma (HCC) recent years, many patients are diagnosed middle or late stages, denying them option for surgical excision. Therefore, it is great importance to find effective therapeutic targets HCC. In this study, found that Gap junction protein beta‐2 (GJB2) highly enriched malignant cells based on single‐cell RNA sequencing and higher expression GJB2 indicates a worse prognosis. The localization HCC cancer...
The dried rhizome of Panax notoginseng is a traditional Chinese herb extensively used for treatment cardiovascular diseases and other ailments. saponins (PNS) are known as the major pharmacologically active constituents. purpose this study was to investigate cardioprotective effects PNS against doxorubicin-induced cardiotoxicity its possible influence on anti-tumor activity doxorubicin. Five groups ICR mice were treated with saline (control group), doxorubicin alone (20 mg/kg i. p.), alone,...
Background Chronic atrial fibrillation (AF) leads to heterogeneous autonomic nerve innervation termed neural remodeling. The quantitative changes in density as a function of remodeling and its association with sustained AF has not been previously determined. Method Results Seven dogs (paced group) were chronically paced electrodes sutured the epicardium left appendages. (control animals) paced. All developed by 5 weeks pacing. fat pads on containing ganglionated plexuses (GP) separated along...
Schizandrin A (Sch A) is a major phytochemical from Schisandra chinensis (Turcz.) Baill. (Schisandraceae), which exerts neuroprotective effect in Alzheimer's disease (AD).To investigate the mechanism of Sch AD.AD group: APP/PS1 transgenic mice served as AD models; + SCH received 2 mg/kg by intragastric administration; WT: C57BL/6 were used control. For vitro assay, mouse microglial BV2 cells treated with 0.5 µg/mL lipopolysaccharide or combined 10 μmol/L for 24 h. The cognitive function and...
To investigate the clinical effects of mindfulness-based stress reduction (MBSR) intervention combined with early cardiac rehabilitation (CR) on patients acute myocardial infarction (AMI) assisted an intra-aortic balloon pump (IABP).A total 100 AMI IABP assistance due to hemodynamic instability at Wuhan Asia Heart Hospital were enrolled in study. The participants divided into two groups using random number table method (n = 50 each group). Patients receiving routine CR assigned control...
Abstract Myocardial infarction (MI) triggers a poor ventricular remodeling response, but the underlying mechanisms remain unclear. Here, authors show that sentrin‐specific protease 1 (SENP1) is downregulated in post‐MI mice and patients with severe heart failure. By generating cardiomyocyte‐specific SENP1 knockout overexpression to assess cardiac function responses under physiological pathological conditions. Increased fibrosis deletion mice, associated increased fibronectin (Fn) expression...
Mutations in hERG cause long QT syndrome type 2 which is characterized by a prolonged interval on electrocardiogram and predisposition to life-threatening ventricular tachyarrhythmia, syncope sudden death. hERG-G572S induces trafficking defects of channel protein from Golgi the plasma membrane results dominant negative suppression current density. As an accessory β subunit, KCNE2 promotes migration cellular membrane. In this study, we investigated rescue effect G572S mutation hERG....
To study the chemical constituents of fruits noni (Morinda citrifolia L.), and find novel compounds, an n-butanol extract ethanol soluble fraction was subjected to repeated silica gel ODS column chromatography HPLC. Two new glycosides were isolated their structures elucidated by NMR HRFAB-MS spectrometry as (2E,4E,7Z)-deca-2,4,7-trienoate-2-O-β-D-glucopyranosyl-β-D-glucopyra-noside (1) amyl-1-O-β-D-apio-furanosyl-1,6-O-β-D-glucopyranoside (2), respectively.