A5100699854- Atherosclerosis and Cardiovascular Diseases
- Berberine and alkaloids research
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Venous Thromboembolism Diagnosis and Management
- Plant-based Medicinal Research
- Ginseng Biological Effects and Applications
- Metabolism, Diabetes, and Cancer
- Cardiovascular Disease and Adiposity
- Diet, Metabolism, and Disease
- Fibroblast Growth Factor Research
- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Kruppel-like factors research
- Lipid metabolism and disorders
- Chronic Kidney Disease and Diabetes
- Diabetes Management and Research
- Cancer, Lipids, and Metabolism
- Chromatography in Natural Products
- Gout, Hyperuricemia, Uric Acid
- Sphingolipid Metabolism and Signaling
- Advanced Glycation End Products research
- Animal Virus Infections Studies
- Immune Response and Inflammation
Tongji Hospital
2013-2024
Huazhong University of Science and Technology
2005-2024
Heilongjiang University of Chinese Medicine
2020-2024
Jiamusi University
2024
Second Affiliated Hospital of Dalian Medical University
2022-2024
Chinese Academy of Sciences
2024
Nankai University
2024
Dalian Medical University
2022-2024
Wuhan Institute of Virology
2024
Wenzhou Medical University
2023
Oxidative stress and inflammation play essential roles in the development progression of diabetic nephropathy (DN). Baicalin (BAI), a natural flavonoid, has been showed to have renoprotective effect various renal diseases. However, its underlying mechanisms DN remain unclear. In this study, we explored potential effects BAI on using spontaneous model.The protective evaluated by detecting DN-related biochemical indicators, kidney histopathology cell apoptosis. After that, examined level...
Aims: Impaired fatty acid oxidation (FAO) in mitochondria of hepatocytes causes lipid accumulation and excessive production reactive oxygen species (ROS) oxidative damage, leading to nonalcoholic liver disease (NAFLD). Fatty translocase (FAT/cluster differentiation 36 [CD36]), a transmembrane protein that facilitates the uptake long-chain acids (LCFAs), is recently found be involved FAO. The function FAT/CD36 associated with its subcellular localization. Palmitoylation, one most common...
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic and characterized by excessive hepatic lipid accumulation. Many studies have suggested that overload key initial factor contributes to steatosis. Our previous study indicated diosgenin (DSG) has a beneficial effect on energy metabolism, but underlying mechanism remains unclear.Human normal hepatocytes (LO2 cells) were incubated with palmitic acid establish cell model of nonalcoholic liver. The effects DSG glucose uptake...
Objective Dysbiosis of the intestinal fungal community has been observed in inflammatory bowel disease (IBD); however, its potential role IBD development and prevention remains unclear. Here, we explored biological effects molecular mechanisms fungi isolated from human faeces on colitis mice. Design Intestinal strains with differential abundance were cultivated their various mouse models experimental evaluated. In addition, bioactive metabolites secreted by target fungus accurately...
Abstract Background The gut virome has been implicated in inflammatory bowel disease (IBD), yet a full understanding of the IBD patients, especially across diverse geographic populations, is lacking. Results In this study, we conducted comprehensive virome-wide association study Chinese cohort 71 patients (15 with Crohn’s and 56 ulcerative colitis) 77 healthy controls via viral-like particle (VLP) bulk sequencing their feces. By utilizing an integrated virus catalog tailored to virome,...
Background Complement-C1q TNF-related protein 1 (CTRP1), a member of the CTRP superfamily, possesses anti-inflammatory and anti-diabetic effects in mice. However, clinical relevance CTRP1 has been seldom explored. The current study aimed to investigate association circulating type 2 diabetes mellitus (T2DM) Chinese population. Design Methods Serum adiponectin levels 96 T2DM patients 85 healthy subjects were determined by ELISA, their associations with adiposity, glucose lipid profiles...
The aim of the present study is to explore molecular mechanism fibroblast growth factor 21 (FGF21) in protecting against diabetic cardiomyopathy (DCM). Streptozotocin/high-fat diet (STZ/HFD) was used induced diabetes FGF21-deficient mice and their wild-type littermates, followed by evaluation difference DCM between two genotypes. Primary cultured cardiomyocytes were also potential FGF21 protection high glucose (HG)-induced cardiomyocyte injury. STZ/HFD-induced exacerbated knockout mice,...
Accumulating studies revealed that 6-gingerol, a compound extracted mainly from ginger, treats obesity by preventing hyperlipidemia in vivo induced high-fat-diet (HFD). The present study intends to further evaluate the efficacy of 6-gingerol treatment and investigate its potential mechanism. Obese mice were established HFD induction. Bioinformatic analysis was used predict possible pathways enrolled application 6-gingerol. Body weight levels blood glucose lipids examined analyzed for...
Several studies have documented the effects of hypoxia and ceramides on lipid glucose metabolism, resulting in insulin resistance. However, roles ceramide hepatic resistance remain to be clarified. This study aimed explore relationship between hypoxia, synthesis, high-fat diet (HFD)-fed mice. Given interaction hypoxia-inducible factors 2α(HIF-2α) berberine determined using molecular docking, this also assessed pharmacological HIF-2α-ceramide-insulin pathway. In preliminary phase study,...
The objective of this study was to assess the effect sitagliptin on insulin dose in patients with inadequately controlled type 2 diabetes who titrate basal a target fasting glucose level after initiating sitagliptin.This multicenter, randomized, double-blind, placebo-controlled, 24-week clinical trial which treatment 100 mg/day or placebo administered concurrently glargine titration, targeting 4.0-5.6 mmol/L (72-100 mg/dL). randomized 660 and inadequate glycemic control insulin, without...
Abstract Background Accumulating evidence indicated that necroptosis plays an essential role in the pathogenesis of inflammatory bowel disease (IBD). The O -linked β- N -acetylglucosaminylation ( -GlcNAcylation) necroptotic signal molecule receptor-interacting serine-threonine kinase 3 (RIPK3) was reported to exert a protective effect gut inflammation. Our recent study suggested traditional Chinese herbal formula Wu-Mei-Wan (WMW) as effective prescription mouse colitis. However, potential...
Genetic predisposition to coronavirus disease 2019 (COVID-19) may contribute its morbidity and mortality. Because cytokines play an important role in multiple phases of infection, we examined whether commonly occurring, functional polymorphisms macrophage migration inhibitory factor (MIF) are associated with COVID-19 infection or severity.To determine associations common MIF symptomatic severity.This retrospective case-control study utilized 1171 patients from three tertiary medical centers...
Soluble C-X-C chemokine ligand 16 (CXCL16), a scavenger receptor for oxidized low density lipoprotein, has been shown to promote atherogenic effects in vivo and predict long-term mortality acute coronary syndrome. The aim of this study was explore the association circulating CXCL16 levels with diabetic subjects without renal disease.One hundred twenty Chinese subjects, which included patients type 2 diabetes mellitus (T2DM), nephropathy (DN), CKD, as well healthy controls, were enrolled...
Hepatitis E virus (HEV) is one of the primary causative agents acute hepatitis, and represents a major cause severe public health problems in developing countries. The pathogenesis HEV not well characterized, however, primarily due to lack well-defined cell animal models. Here, we investigated effects genotype 1 open reading frame 3 (ORF3) on TNF-α-induced nucleus factor-κappa B (NF-κB) signaling. Human lung epithelial cells (A549) were transiently transfected with ORF3 containing plasmids....