A5058084271- Macrophage Migration Inhibitory Factor
- Parasites and Host Interactions
- Nuclear Receptors and Signaling
- Synthesis of heterocyclic compounds
- Immune cells in cancer
- Cancer Research and Treatments
- Mosquito-borne diseases and control
- Trypanosoma species research and implications
- Viral Infections and Vectors
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Education and Character Development
- Autophagy in Disease and Therapy
- interferon and immune responses
- Adenosine and Purinergic Signaling
- Malaria Research and Control
Inserm
2010-2024
University of Antwerp
2024
La Ligue Contre le Cancer
2024
Université de Bourgogne
2024
Centre National de la Recherche Scientifique
2010-2022
Université Bourgogne Franche-Comté
2022
Centre d’Immunologie de Marseille-Luminy
2022
Aix-Marseille Université
2022
Yale University
2012-2021
Yale Cancer Center
2014
Abstract Plasmodium species produce an ortholog of the cytokine macrophage migration inhibitory factor, PMIF, which modulates host inflammatory response to malaria. Using a novel RNA replicon-based vaccine, we show impact PMIF immunoneutralization on and observed improved control liver blood-stage infection, complete protection from re-infection. Vaccination against delayed patency after sporozoite reduced expression Th1-associated markers TNF-α, IL-12, IFN-γ during augmented Tfh cell...
While stimulator of interferon genes (STING) activation in innate immune cells the tumor microenvironment can result CD8 T cell-dependent antitumor immunity, whether STING signaling affects CD4 T-cell responses remains elusive.Here, we tested modulated effector functions vivo by analyzing tumor-infiltrating and evaluating contribution cell-derived cytokines activity ligand 2'3'-cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) two mouse models. We performed ex experiments to...
We have identified and characterized a Macrophage Migration Inhibitory Factor (MIF) family member in the Lophotrochozoan invertebrate, Biomphalaria glabrata, snail intermediate host of human blood fluke Schistosoma mansoni. In mammals, MIF is widely expressed pleiotropic cytokine with potent pro-inflammatory properties that controls cell functions such as gene expression, proliferation or apoptosis. Here we show protein from B. glabrata (BgMIF) circulating immune defense cells (hemocytes)...
The role of the cytokine, macrophage migration inhibitory factor (MIF), and its receptor, CD74, was assessed in autoimmune hepatitis (AIH) primary biliary cirrhosis (PBC). Two MIF promoter polymorphisms, a functional -794 CATT5-8 microsatellite repeat (rs5844572) -173 G/C single-nucleotide polymorphism (rs755622), were analyzed DNA samples from over 500 patients with AIH, PBC, controls. We found higher frequency proinflammatory high-expression CATT7 allele compared to whereas lower both AIH...
Genetic predisposition to coronavirus disease 2019 (COVID-19) may contribute its morbidity and mortality. Because cytokines play an important role in multiple phases of infection, we examined whether commonly occurring, functional polymorphisms macrophage migration inhibitory factor (MIF) are associated with COVID-19 infection or severity.To determine associations common MIF symptomatic severity.This retrospective case-control study utilized 1171 patients from three tertiary medical centers...
Leishmania major encodes 2 orthologs of the cytokine macrophage migration inhibitory factor (MIF), whose functions in parasite growth or host-parasite interaction are unknown. To determine importance Leishmania-encoded MIF, both LmMIF genes were removed to produce an mif–/– strain L. major. This mutant replicated normally vitro but had a 2-fold increased susceptibility clearance by macrophages. Mice infected with major, when compared wild-type strain, also showed 3-fold reduction burden....
The Plasmodium falciparum orthologue of the human cytokine, macrophage migratory inhibitory factor (PfMIF), is produced by parasite during malaria infection and modulates host's immune response. As for other MIF orthologues, PfMIF has tautomerase activity, whose inhibition may influence cytokine activity. To identify small-molecule inhibitors activity PfMIF, virtual screening been performed docking 2.1 million compounds into enzymatic site. Assaying 17 identified four as active. Substructure...
We report the crystal structures of two inhibitors Plasmodium falciparum macrophage migration inhibitory factor (PfMIF) with nanomolar Ki's, analyze their interactions active site PfMIF, and provide explanations regarding selectivity PfMIF versus human MIF. These were also found to selectively inhibit between MIF receptor CD74. The results this study framework for development new therapeutics that target PfMIF.
T cells expressing invariant γδ antigen receptors (γδ cells) bridge innate and adaptive immunity facilitate barrier responses to pathogens. Macrophage migration inhibitory factor (MIF) is an upstream mediator of host defense that up-regulates the expression pattern recognition sustains inflammatory by inhibiting activation-induced apoptosis in monocytes macrophages. Surprisingly, Mif−/− cells, when compared with wild type, were observed produce >10-fold higher levels proinflammatory cytokine...
The deadliest complication of infection by Plasmodium parasites, cerebral malaria, accounts for the majority malarial fatalities. Although our understanding cellular and molecular mechanisms underlying pathology remains incomplete, recent studies support contribution systemic neuroinflammation as cause edema blood-brain barrier (BBB) dysfunction. All species encode an orthologue innate cytokine, Macrophage Migration Inhibitory Factor (MIF), which functions in mammalian biology to regulate...
Abstract Malaria begins when mosquito-borne Plasmodium sporozoites invade hepatocytes and usurp host pathways to support the differentiation multiplication of erythrocyte-infective merozoite progeny. The deadliest complication infection, cerebral malaria, accounts for majority malarial fatalities. Although our understanding cellular molecular mechanisms underlying pathology remains incomplete, recent studies contribution systemic neuroinflammation as cause edema blood-brain barrier (BBB)...