A5010256009- Immune cells in cancer
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- NF-κB Signaling Pathways
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Inflammasome and immune disorders
- Cytokine Signaling Pathways and Interactions
- Atherosclerosis and Cardiovascular Diseases
- Chemokine receptors and signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Immune responses and vaccinations
- Phagocytosis and Immune Regulation
- Cell Adhesion Molecules Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Lipids, and Metabolism
- Reproductive System and Pregnancy
- Platelet Disorders and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Research and Treatments
- Extracellular vesicles in disease
- Cholesterol and Lipid Metabolism
King's College London
2018-2025
Centre d’Immunologie de Marseille-Luminy
2015-2024
Aix-Marseille Université
2014-2024
Centre National de la Recherche Scientifique
2014-2024
Inserm
2014-2024
Xinxiang Medical University
2019-2022
Kings Health Partners
2021-2022
Cancer Research UK
2021-2022
Living Systems (United States)
2021
Wesleyan University
2021
The nuclear factor κB (NF-κB) signaling pathway is important in cancer-related inflammation and malignant progression. Here, we describe a new role for NF-κB cancer maintaining the immunosuppressive phenotype of tumor-associated macrophages (TAMs). We show that are polarized via interleukin (IL)-1R MyD88 to an “alternative” requires IκB kinase β–mediated activation. When inhibited specifically TAMs, they become cytotoxic tumor cells switch “classically” activated phenotype; IL-12high, major...
Abstract GM-CSF and M-CSF (CSF-1) can enhance macrophage lineage numbers as well modulate their differentiation function. Of recent potential significance for the therapy of inflammatory/autoimmune diseases, blockade in relevant animal models leads to a reduction disease activity. What critical actions are these CSFs on macrophages during inflammatory reactions unknown. To address this issue, adherent (GM-BMM BMM) were first derived from murine bone marrow precursors by M-CSF, respectively,...
Glucocorticoids (GCs), which are used in the treatment of immune-mediated inflammatory diseases, inhibit expression many mediators. They can also induce dual specificity phosphatase 1 (DUSP1; otherwise known as mitogen-activated protein kinase [MAPK] 1), dephosphorylates and inactivates MAPKs. We investigated role DUSP1 antiinflammatory action GC dexamethasone (Dex). Dex-mediated inhibition c-Jun N-terminal p38 MAPK was abrogated DUSP1−/− mouse macrophages. suppression several...
The World Health Organization estimates that lower respiratory tract infections (excluding tuberculosis) account for ∼35% of all deaths caused by infectious diseases. In many cases, the cause death may be multiple pathogens, e.g., life-threatening bacterial pneumonia observed in patients infected with influenza virus. ability to evolve more efficient immunity on each successive encounter antigen is hallmark adaptive immune response. However, absence cross-reactive T and B cell epitopes, one...
Cytokines orchestrate the tumor-promoting interplay between malignant cells and immune system. In many experimental human cancers, cytokine TNF-alpha is an important component of this interplay, but its effects are pleiotropic therefore remain to be completely defined. Using a mouse model ovarian cancer in which either TNF receptor 1 (TNFR1) signaling was manipulated different leukocyte populations or neutralized by antibody treatment, we found that inflammatory maintained TNFR1-dependent...
Experimental and clinical evidence suggests that tumor-associated macrophages (TAMs) play important roles in cancer progression. Here, we have characterized the ontogeny function of TAM subsets a mouse model metastatic ovarian is representative for visceral peritoneal metastasis. We show omentum critical premetastatic niche development invasive disease this define unique subset CD163+ Tim4+ resident omental responsible spread cells. Transcriptomic analysis showed were phenotypically distinct...
Tumor-associated macrophages (TAMs) play critical roles in tumor progression but are also capable of contributing to antitumor immunity. Recent studies have revealed an unprecedented heterogeneity among TAMs both human cancer and experimental models. Nevertheless, we still understand little about the contribution different TAM subsets progression. Here, demonstrate that CD163-expressing specifically maintain immune suppression model melanoma is resistant anti-PD-1 checkpoint therapy....
Immune cells experience large cell shape changes during environmental patrolling because of the physical constraints that they encounter while migrating through tissues. These can adapt to such deformation events using dedicated shape-sensing pathways. However, how sensing affects immune function is mostly unknown. Here, we identify a mechanism increases expression chemokine receptor CCR7 and guides dendritic migration from peripheral tissues lymph nodes at steady state. This relies on lipid...
Transcription factor, nuclear factor κB (NF-κB), is required for osteoclast formation in vivo and mice lacking both of the NF-κB p50 p52 proteins are osteopetrotic. Here we address relative roles two catalytic subunits IκB kinase (IKK) complex that mediate activation, IKKα IKKβ, inflammation-induced bone loss. Our findings point out importance IKKβ subunit as a transducer signals from receptor activator (RANK) to NF-κB. Although RANK ligand-induced vitro, it not needed vivo. However,...
Hematopoietic prostaglandin D(2) synthase (hPGD(2)S) metabolizes cyclooxygenase (COX)-derived PGH(2) to PGD(2) and 15-deoxyDelta(12-14) PGJ(2) (15d-PGJ(2)). Unlike COX, the role of hPGD(2)S in host defense is ambiguous. can be either pro- or antiinflammatory depending on disease etiology, whereas existence 15d-PGJ(2) its relevance pathophysiology remain controversial. Herein, studies KO mice reveal that synthesized a self-resolving peritonitis, detected by using liquid chromatography-tandem...
Group B Streptococcus (GBS) is a major cause of pneumonia, bacteremia, and meningitis in neonates has been found to persist inside host phagocytic cells. The pore-forming GBS β-hemolysin/cytolysin (βH/C) encoded by cylE an important virulence factor as demonstrated several vivo models. Interestingly, deletion results not only the loss βH/C activity, but also carotenoid pigment unknown function. In this study, we sought define mechanism(s) which may contribute phagocyte resistance increased...