A5048654641- Biomarkers in Disease Mechanisms
- Immune cells in cancer
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Agricultural safety and regulations
- Cancer Immunotherapy and Biomarkers
- Cell Adhesion Molecules Research
- T-cell and B-cell Immunology
- Pesticide Residue Analysis and Safety
- Cytokine Signaling Pathways and Interactions
- Phagocytosis and Immune Regulation
- Reproductive System and Pregnancy
- Inflammasome and immune disorders
- IL-33, ST2, and ILC Pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Effects and risks of endocrine disrupting chemicals
- Genetically Modified Organisms Research
- Atherosclerosis and Cardiovascular Diseases
- Inflammatory Biomarkers in Disease Prognosis
- COVID-19 Clinical Research Studies
- Angiogenesis and VEGF in Cancer
- Monoclonal and Polyclonal Antibodies Research
Humanitas University
2016-2025
IRCCS Humanitas Research Hospital
2016-2025
William Harvey Research Institute
2017-2025
Queen Mary University of London
2017-2025
University of Turin
1986-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2024
University of Milan
2013-2023
Istituto Superiore di Sanità
1998-2022
Fondazione Humanitas per la Ricerca
2008-2017
Universidade do Oeste de Santa Catarina
2017
Abstract Comprehensive analysis of the gene expression profiles associated with human monocyte-to-macrophage differentiation and polarization toward M1 or M2 phenotypes led to following main results: 1) M-CSF-driven is activation cell cycle genes, substantiating underestimated proliferation potential monocytes. 2) M-CSF leads a substantial part transcriptome, suggesting that under homeostatic conditions default shift occurs. 3) Modulation genes involved in metabolic activities prominent...
T helper cells type 1 (Th1s) that produce interferon-γ predominantly mediate cellular immune responses and are involved in the development of chronic inflammatory conditions, whereas Th2s which large amounts IL-4 IL-5 upregulate IgE production prominent pathogenesis allergic diseases. The precise factors determining whether Th1- or Th2-mediated preferentially occur at a peripheral site antigen exposure largely unknown. Chemokines, superfamily polypeptide mediators, key component leukocyte...
Phosphoinositide 3-kinase (PI3K) activity is crucial for leukocyte function, but the roles of four receptor-activated isoforms are unclear. Mice lacking heterotrimeric guanine nucleotide-binding protein (G protein)–coupled PI3Kγ were viable and had fully differentiated neutrophils macrophages. Chemoattractant-stimulated −/− did not produce phosphatidylinositol 3,4,5-trisphosphate, activate kinase B, displayed impaired respiratory burst motility. Peritoneal PI3Kγ-null macrophages showed a...