A5101640480- Heat shock proteins research
- Epigenetics and DNA Methylation
- Neurotransmitter Receptor Influence on Behavior
- RNA modifications and cancer
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Cancer Immunotherapy and Biomarkers
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- S100 Proteins and Annexins
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Immune Cell Function and Interaction
- ATP Synthase and ATPases Research
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Immune cells in cancer
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Pancreatic function and diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Response and Inflammation
- Angiogenesis and VEGF in Cancer
- Forensic Toxicology and Drug Analysis
Hefei Institutes of Physical Science
2024-2025
Chinese Academy of Sciences
2016-2025
Changhai Hospital
2025
Second Military Medical University
2025
Second Affiliated Hospital of Zhejiang University
2025
Wuhan Children's Hospital
2020-2025
Kunming Medical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2025
Deyang Stomatological Hospital
2023-2025
Anhui University
2024
Targeted inhibition of the molecular chaperone Hsp90 results in simultaneous blockade multiple oncogenic signaling pathways and has, thus, emerged as an attractive strategy for development novel cancer therapeutics. Ganetespib (formerly known STA-9090) is a unique resorcinolic triazolone inhibitor that currently clinical trials number human cancers. In present study, we showed ganetespib exhibits potent vitro cytotoxicity range solid hematologic tumor cell lines, including those express...
Abstract Squamous cell carcinomas (SCCs) are common and aggressive malignancies. Immune check point blockade (ICB) therapy using PD-1/PD-L1 antibodies has been approved in several types of advanced SCCs. However, low response rate treatment resistance common. Improving the efficacy ICB requires better understanding mechanism immune evasion. Here, we identify that SCC-master transcription factor TP63 suppresses interferon-γ (IFNγ) signaling. inhibition leads to increased CD8 + T infiltration...
The binding of endothelin-1 (ET-1) to endothelin type A receptor (ETAR) performs a critical action in pulmonary arterial smooth muscle cell (PASMC) proliferation leading vascular structural remodeling. More evidence showed that cystathionine γ-lyase (CSE)-catalyzed endogenous hydrogen sulfide (H2S) was involved the pathogenesis cardiovascular diseases. In this study, we aimed explore effect H2S/CSE pathway on ET-1/ETAR and its underlying mechanisms cellular animal models PASMC proliferation....
The A3 adenosine receptor is widely expressed in human tissues with the most abundant expression lung and liver, but predominant cellular localization functions of this humans are unknown. Since influences activation circulating resident inflammatory cells within leads to exaggerated airway narrowing individuals disorders, we hypothesized that gene localized upregulated inflammation. Lung tissue were obtained at thoracotomy from nonsmoking subjects disorders associated tobacco smoke or...
Background/Aims: Diabetes mellitus (DM) characterized by hyperglycemia contributes to macrovascular and microvascular complications. Salvianolic acid A (SalA) is a polyphenolic compound isolated from the root of Salvia miltiorrhiza Bunge, which traditional Chinese medicine widely used treat cardiovascular diseases. However, little known about its antidiabetic effect. Our study aimed investigate in vivo vitro effect SalA underlying mechanisms. Methods: Alloxan-induced type 1 diabetic mice...
Systemic chemotherapy using two-drug platinum-based regimens for the treatment of advanced stage non-small cell lung cancer (NSCLC) has largely reached a plateau effectiveness. Accordingly, efforts to improve survival and quality life outcomes have more recently focused on use molecularly targeted agents, either alone or in combination with standard care therapies such as taxanes. The molecular chaperone heat shock protein 90 (Hsp90) represents an attractive candidate therapeutic...
ABSTRACT Organoid culture systems are very powerful models that recapitulate in vivo organ development and disease pathogenesis, offering great promise basic research, drug screening precision medicine. However, the application of organoids derived from patients with cancer to immunotherapeutic research is a relatively untapped area. Esophageal one most lethal malignancies worldwide, including two major pathological subtypes: esophageal squamous cell carcinoma (ESCC) adenocarcinoma. ESCC...
Sarcopenia is an age-related muscle senescence disease that leads to functional limitations, physical disability and premature death in older adults. Atherogenic index of plasma (AIP) a novel indicator atherosclerotic status based on triglycerides high-density lipoprotein cholesterol. The aim this study was investigate the association between AIP new-onset sarcopenia its components among middle-aged adults Chinese community. This cohort included 7,992 participants who were free 2011 China...
vNOTES has been documented as a viable approach for conducting benign gynecologic surgery; however, its application in ectopic pregnancy cases remains relatively scarce. The principal objective of this investigation was to assess the practicability, effectiveness, and safety surgical procedures related pregnancy. Clinical data pertaining patients diagnosed with at Beijing Hospital between January 2018 August 2023 were retrospectively collected (This study registered China Trial Registry...
Chimeric antigen receptor-T (CAR-T) cell therapy is a cellular immunotherapy that has emerged in recent years, and increasing studies showed therapeutic resistance to CAR-T presents colorectal cancer patients. Lipopolysaccharide (LPS), component of the wall Gram-negative bacteria, known preserve high concentration colon. Whether LPS contributing factor development cells against remains unclear. For vivo experiments, COLO205 were pretreated with for 24 h then injected into nude mice through...
This study aims to investigate the level of health-promoting lifestyles and its influencing factors in Chinese patients with colorectal polyps. A total 169 polyps from three tertiary care hospitals Nanchong Deyang, China, were recruited. Data collected using Impact Health-Promoting Lifestyle Profile-II (HPLP-IIR), Colorectal Cancer Knowledge Questionnaire, Health Belief Scale, version Information Literacy Self-Rating a demographic questionnaire. Factors analyzed multiple linear regression...
JAM3, an adhesion and transmigration regulatory element, is abundantly expressed in intestinal epithelial cells. However, its expression function colorectal cancer (CRC) remain unknown. In this study, we explored epigenetic mechanism biological role CRC.Bioinformatics analysis was used to analyze the methylation level of JAM3 CRC. Methylation status were then validated by quantitative methylation-specific PCR (qMSP) tissues, plasma samples, cell lines. Flow cytometry, Western blot,...
Brain lipid homoeostasis is critical during recovery process after traumatic brain injury (TBI). In this study, we integrated liquid extraction and electrosonic spray ionization technology to develop an device coupled with a Fourier transform ion cyclotron resonance mass spectrometer for imaging of docosahexaenoic acid (DHA)-containing lipids on rat tissues. The images the tissue sections from normal rats TBI at acute phase (0 1 day) chronic (3, 5, 7 days) were obtained. results indicate...
OBJECTIVE To investigate risk factors of lymph node metastasis (LNM) in early gastric carcinoma (EGC) four tertiary medical centers Jiangsu Province, China. METHODS Among 10 097 consecutive combined cancer radical resections, 1903 EGC were identified and reviewed, 283 excluded 1620 included the study. All pathological some endoscopic reports reviewed for patients’ characteristics, tumor location, gross features, number nodes retrieved involved. Two pathologists independently investigated...
Physical activity promotes metabolic and cardiovascular health benefits that derive in part from the transcriptional responses to exercise occur within skeletal muscle other organs. There is interest discovering a pharmacologic mimetic could imbue wellness alleviate disease burden. However, molecular physiology by which signals response highly complex, making it challenging identify single target for pharmacological mimicry. The current studies evaluated transcriptome muscle, heart, liver,...