A5017227465- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Mesenchymal stem cell research
- Cancer Immunotherapy and Biomarkers
- Indoor and Outdoor Localization Technologies
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Neurogenesis and neuroplasticity mechanisms
- Tissue Engineering and Regenerative Medicine
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Chromatin Remodeling and Cancer
- Kruppel-like factors research
- Virus-based gene therapy research
- Cytokine Signaling Pathways and Interactions
- Robotics and Sensor-Based Localization
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- Inertial Sensor and Navigation
First Affiliated Hospital of Xiamen University
2016-2024
Fujian Medical University
2013-2024
Shanghai University of Sport
2024
Yan'an Hospital Affiliated To Kunming Medical University
2014-2023
Kunming Medical University
2014-2023
The University of Texas Health Science Center at San Antonio
2021-2023
The University of Texas Health Science Center at Houston
2021-2023
Liaoning Cancer Hospital & Institute
2023
Nanjing Medical University
2019-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2022
N6-methyladenosine (m6A) has emerged as the most prevalent post-transcriptional modification on mRNA that contributes prominently to tumorigenesis. However, specific function of m6A methyltransferase methyltransferase-like 3 (METTL3) in colorectal cancer (CRC) remains elusive. Herein, we explored biological METTL3 CRC progression. Clinically, was frequently upregulated tissues, cell lines, and plasma samples its high expression predicted poor prognosis patients. Functionally, knockdown...
Abstract Background Aberrant DNA methylation is a major characteristic of cancer genomes. It remains unclear which biological processes determine epigenetic reprogramming and how these influence the variants in methylome, can further impact phenotypes. Methods We performed pairwise permutations 381,900 loci 569 paired profiles tissue matched normal from The Cancer Genome Atlas (TCGA) defined conserved differentially methylated positions (DMPs) based on resulting null distribution. Then, we...
JAM3, an adhesion and transmigration regulatory element, is abundantly expressed in intestinal epithelial cells. However, its expression function colorectal cancer (CRC) remain unknown. In this study, we explored epigenetic mechanism biological role CRC.Bioinformatics analysis was used to analyze the methylation level of JAM3 CRC. Methylation status were then validated by quantitative methylation-specific PCR (qMSP) tissues, plasma samples, cell lines. Flow cytometry, Western blot,...
// Yihan Ma 1 , Xiaoyan Pan 1, 2 Peiqi Xu 3 Yanjun Mi Wenyi Wang Xiaoting Wu Qi He Xinli Liu Weiwei Tang and Han-Xiang An Xiamen Cancer Hospital the First Affiliated of University, 361003 Fujian, China Department Medical Oncology, Linyi Hospital, 276000 Shandong, Reproduction Center, The Second Kunming 650101 Yunnan, Correspondence to: An, email: anhanxiang@xmu.edu.cn Keywords: EGFR, EGFR-TKI, NSCLC, circulating miRNA, primary resistance Received: November 02, 2016 Accepted: July 18, 2017...
Andrographolide(ADE) has been demonstrated to inhibit tumor growth through direct cytotoxicity on cells. However, its potential activity microenvironment (TME) remains unclear. Tumor-associated macrophages (TAMs), composed mainly of M2 macrophages, are the key cells that create an immunosuppressive TME by secretion cytokines, thus enhancing progression. Re-polarized subpopulations may represent vital new therapeutic alternatives. Our previous studies showed ADE possessed anti-metastasis and...
Cytokine-induced killer (CIK) cells are an emerging approach of cancer treatment. Our previous study have shown that CIK stimulated with combination IL-2 and IL-15 displayed improved proliferation capacity tumor cytotoxicity. However, the mechanisms cell acquisition cytolytic function against induced by not been well elucidated yet. CIKIL-2 CIKIL-15 were generated from peripheral blood mononuclear primed IFN-γ, in OKT3 respectively. RNA-seq was performed to identify differentially expressed...
// Dan Zhou 1, 2 , Weiwei Tang 1 Xinli Liu Han-Xiang An and Yun Zhang Department of Medical Oncology, The First Affiliated Hospital Xiamen University, Xiamen, Fujian, China Institute Rare Earth Materials, Chinese Academy Sciences Key Laboratory Design Assembly Functional Nanostructures, Fujian Provincial Nanomaterials, Research on the Structure Matter, Sciences, Correspondence to: Zhang, email: zhangy@fjirsm.ac.cn An, anhanxiang@xmu.edu.cn Keywords: lung cancer, biomarker, cell-free RNA,...
The success of developing cardiovascular tissue engineering (CTE) grafts greatly needs a readily available cell substitute for endothelial and interstitial cells. Perinatal annexes have been proposed as valuable source mesenchymal stem cells (MSCs) regenerative medicine. objective the present study is to evaluate potential human Wharton's jelly MSCs (WJ-MSCs) amniotic membrane (AM-MSCs) seeding in CTE WJ-MSCs/AM-MSCs were isolated characterized vitro according their morphology,...
Protocadherin18 (PCDH18) was found to be preferentially methylated and inactivated in colorectal cancer (CRC) using bioinformatics tools. However, its biologic role tumorgenesis remains unclear. Herein, we aimed elucidate epigenetic regulation biological functions CRC. The methylation status of PCDH18 significant higher CRC tissues than adjacent non-tumor (median, 15.17% vs. median, 0.4438%). Expression level significantly lower primary CRCs nonmalignant tissues. Importantly, cell-free DNA...
Human mesenchymal stem cells (hMSCs) have been applied in a variety of therapies recently. However, the role MSCs tumor progression remains largely elusive. Some studies demonstrated that can promote growth, while others had opposite results. Therefore, lack evidence about effect on impedes its further use.In current study, hMSCs from amniotic membrane (hAMSCs) and umbilical cord (hUCMSCs) were used to evaluate effects development vitro vivo. Two different animal models based subcutaneous...
Upregulation of nuclear factor-κB (NF-κB) in colorectal carcinoma (CRC) accelerates tumor growth, whereas, irinotecan (CPT-11)-induced NF-κB activation reduces chemosensitivity and weakens the anti-colorectal cancer function itself, while proteasome inhibitors can inhibit improve effect chemotherapy. Carfilzomib (CFZ) is a novel inhibitor that has been recently approved by FDA clinical use for treatment multiple myeloma, but little known about its activity against CRC. The aim present study...
Even though postoperative chemotherapy can eliminate residual tumor cells in patients with colorectal cancer (CRC), severe adversity, weakened immunity and drug resistance are still problems. Adjuvant cytokine-induced killer (CIK) cell therapy is an alternative to CRC after surgery. The present study investigated the efficacy of adjuvant CIK combined patients.This retrospective analysis included 137 patients, including 71 who received alone (control group) 66 immunotherapy based on (CIT...
Wearable sensors and smart phones have been used in human activity recognitions can achieve relative high accuracy however the power consumption is also high. In this paper, we propose an recognition approach that with low consumption. Two strategies applied to reduce The first strategy using hierarchical support vector machine classification algorithm computational complexity. second sensor data sampling rates. Data collected from rate were processed a wider time window for feature...
Abstract A fast and direct competitive biomimetic enzyme‐linked immunosorbent assay (BELISA) method was developed for the determination of methimazole (MMZ) in urine sample based on a molecularly imprinted film as an artificial antibody. This is first example to monitor with method. The directly synthesized well surface MaxiSorp polystyrene 96‐well plate characterized. results showed that it exhibited antibody‐like binding ability, rapid adsorption speed, high stability, which particularly...
Gastric cancer (GC) is the third leading cause of cancer-related death worldwide, partially due to lack effective screening strategies. Thus, there a stringent need for non-invasive biomarkers improve patient diagnostic efficiency in GC.This study initially filtered messenger RNAs (mRNAs) as prospective through bioinformatics analysis. Clinical validation was conducted using circulating mRNA plasma from patients with GC. Relationships between expression levels target genes and...
Lung adenocarcinoma (LUAD), which is associated with high morbidity and mortality, prone to cisplatin resistance, resulting in poor patient prognosis. Long non-coding RNAs (lncRNAs) have complex biological functions a variety of tumors. Elucidating the underlying molecular mechanisms between lncRNA resistance LUAD expected enable identification new targets for drug development.Cell proliferation was measured by CCK-8 assay cell apoptosis detected using flow cytometry analysis. Luciferase...