A5066480766- Cancer-related molecular mechanisms research
- Sirtuins and Resveratrol in Medicine
- Autophagy in Disease and Therapy
- Stress Responses and Cortisol
- Bioactive natural compounds
- Medicinal Plant Pharmacodynamics Research
- Mycobacterium research and diagnosis
- HER2/EGFR in Cancer Research
- Advanced biosensing and bioanalysis techniques
- Neuroendocrine regulation and behavior
- Extracellular vesicles in disease
- Neural Networks and Reservoir Computing
- Quantum Information and Cryptography
- Cell Adhesion Molecules Research
- Parkinson's Disease Mechanisms and Treatments
- Quantum Computing Algorithms and Architecture
- RNA modifications and cancer
- Circular RNAs in diseases
- Tryptophan and brain disorders
- Wireless Networks and Protocols
- Banking Systems and Strategies
- Lung Cancer Treatments and Mutations
- Gut microbiota and health
- Connexins and lens biology
- Radiopharmaceutical Chemistry and Applications
First Affiliated Hospital of Xiamen University
2020-2024
Xiamen University
2020-2024
Central South University
2022-2024
Zunyi Medical University
2019-2023
University of Shanghai for Science and Technology
2022
National University of Defense Technology
2022
Jiangxi University of Traditional Chinese Medicine
2021
Chinese Academy of Tropical Agricultural Sciences
2021
Fujian Medical University
2020
University of Electronic Science and Technology of China
2015
Chemotherapy is commonly used for the treatment of lung cancer, but strong side effects and low efficacy limit its clinical application. Here, extracellular vesicles (EVs) as natural drug delivery carriers were to load conventional anticancer doxorubicin (DOX) a chemosensitizer lonidamine (LND). Two types EVs with different sizes (16k 120k EVs) prepared using centrifugation forces. We found that co-delivery DOX LND both enhanced cytotoxicity reduced dose significantly in vitro. Effective...
Abstract The tumor microenvironment (TME) is related to chronic inflammation and currently identified as a risk factor for the occurrence development of endometrial cancer (EC). Pyroptosis new proinflammatory form programmed cell death that plays critical role in progression multiple diseases. However, important pyroptosis high‐glucose (HG)‐related EC underlying molecular mechanisms remain elusive. In present study, transcriptome high‐throughput sequencing revealed significantly higher...
Rotenone (ROT) is an environmental neurotoxin which has been demonstrated to cause characteristic loss of dopamine (DA) neurons in Parkinson's disease (PD). Icariin (ICA) a flavonoid glucoside isolated from Herba Epimedii that shown display neuroprotective functions. The present study evaluated protective effects ICA on ROT-induced neurotoxicity and determined the modulation regulation autophagy vivo vitro. Rats were treated with ROT (1.0 mg/kg/day) co-administration (15 or 30 for 5 weeks....
Background Considering trophoblast cell surface antigen 2 (Trop2) is overexpressed in a wide range of human epithelial cancers, it presents an attractive target for the diagnosis and treatment multiple types cancer. Herein, we have developed Trop2-specific radiotracer, 68Ga-MY6349, present prospective, investigator-initiated trial to explore clinical values 68Ga-MY6349 PET/CT. Methods In this translational study, 90 patients with 15 cancer, who underwent PET/CT, were enrolled prospectively....
Lung adenocarcinoma (LUAD), which is associated with high morbidity and mortality, prone to cisplatin resistance, resulting in poor patient prognosis. Long non-coding RNAs (lncRNAs) have complex biological functions a variety of tumors. Elucidating the underlying molecular mechanisms between lncRNA resistance LUAD expected enable identification new targets for drug development.Cell proliferation was measured by CCK-8 assay cell apoptosis detected using flow cytometry analysis. Luciferase...
Long non-coding RNA (LncRNA) DUXAP9 expression was recently found to be higher in hepatocellular carcinoma (HCC) tissues and cells, correlated with a shorter overall survival of HCC patients. However, its roles progression have never been revealed. Here, the cell stemness are explored as cancer stem cells (CSCs) contribute one root progression. We that positively regulated stemness, characterized by change sphere-formation ability, ALDH activity marker expression. Further luciferase...
Circulating tumor DNA (ctDNA) is an auspicious biomarker released into the bloodstream by cells, offering abundant information concerning cancer genes. It plays a crucial role in early diagnosis of cancer. However, due to extremely low levels body fluids, achieving simple, sensitive, and highly specific detection ctDNA remains challenging. Here, we constructed purification-free fluorescence biosensor based on quadratic amplification combining nicking enzyme mediated (NEMA) catalytic hairpin...
Modern pharmacological studies have demonstrated that Dendrobium nobile Lindl. Alkaloids (DNLA), the main active ingredients of nobile, is valuable as an anti-aging and neuroprotective herbal medicine. The present study was designed to determine whether DNLA confers protective function over neurotoxicant manganese (Mn)-induced cytotoxicity mechanism involved. Our results showed pretreatment PC12 cells with alleviated cell toxicity induced by Mn improved mitochondrial respiratory capacity...
Quantum process tomography is a pivotal technique in fully characterizing quantum dynamics. However, exponential scaling of the Hilbert space with increasing system size extremely restrains its experimental implementations. Here, we put forward more efficient, flexible, and error-mitigated method: variational entanglement-assisted arbitrary ancillary qubits. Numerically, simulate up to eight-qubit processes show that this m qubits (0≤m≤n) alleviates costs on state preparation (from 4^{n}...
The prevention and treatment of fear-related disorders in offspring affected by pregnancy stress remains challenging at clinic. Here, we examined the effects gut microbiota stressed pregnant rats on fear extinction their offsprings, potential mechanisms. We found that transplantation from with to normal impaired extinction, induced microglial activation synaptic phagocytosis, increased synapse loss offsprings. Probiotics supplement during partly normalized stress-induced dysbiosis rats,...
With photonics, the quantum computational advantage has been demonstrated on task of boson sampling. Next, developing quantum-enhanced approaches for practical problems becomes one top priorities photonic systems. Quantum walks are powerful kernels new and useful algorithms. Here we realize large-scale using a fully programmable computing system. The system integrates silicon chip, enabling simulation walk dynamics graphs with up to 400 vertices possessing full programmability over...
In order to solve the frame overhead influence of transmission performance, improve throughput, lower hybrid scenario user acces delay, (802.11n) especially experience, this paper aimed at different rate terminal equipment, designs RAS algorithm, algorithm through optimizing scheduling, in does not affect delay low speed, reduce high-speed users send time delay.The is reasonable configuration channel resources, make full use high speed rate, various (especially users) experience .In Chariot...
Chronic environmental and occupational exposure to manganese (Mn) results in a progressive neurological disorder referred as manganism, syndrome closely resembling Parkinson's disease (PD). The loss of dopaminergic neurons is critically involved pathological progression Mn‐induced manganism. Identification molecular modulators neurotoxicity essential the development neuroprotective strategies or effective treatments against Mn Mitochondrial dysfunction has been increasingly appreciated key...
Abstract Mitochondrial dysfunction is critically involved in the degeneration of dopamine (DA) neurons substantia nigra (SNc), a common pathological feature Parkinson’s disease (PD). Previous studies have demonstrated that NAD + -dependent acetylase Sirtuin 3 (SIRT3) participates maintaining mitochondrial function and downregulated aging-related neurodegenerative disorders. The exact mechanism action SIRT3 on bioenergetics PD pathogenesis, however, has not been fully described. In this study...