A5103017511- RNA modifications and cancer
- Coronary Interventions and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Hormonal Regulation and Hypertension
- Angiogenesis and VEGF in Cancer
- Cancer-related gene regulation
- Lipoproteins and Cardiovascular Health
- Nanomaterials for catalytic reactions
- Circular RNAs in diseases
- Atherosclerosis and Cardiovascular Diseases
- Virology and Viral Diseases
- Plant-derived Lignans Synthesis and Bioactivity
- Inflammasome and immune disorders
- Renal and related cancers
- Drug Transport and Resistance Mechanisms
- Nanocluster Synthesis and Applications
- Respiratory viral infections research
- Cardiovascular Disease and Adiposity
- Lipid metabolism and disorders
- Apelin-related biomedical research
- Cancer-related molecular mechanisms research
- IL-33, ST2, and ILC Pathways
- Advanced Breast Cancer Therapies
- Plant Virus Research Studies
- Lung Cancer Research Studies
Nanjing University
2006-2025
Second Hospital of Shandong University
2022-2024
First Affiliated Hospital of GuangXi Medical University
2024
Guangxi Medical University
2024
Second Affiliated Hospital of Dalian Medical University
2014-2024
Dalian Medical University
2014-2024
Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine
2024
Shandong University
2018-2022
State Key Laboratory of Crystal Materials
2022
Shandong First Medical University
2015-2021
Abstract The tumor microenvironment (TME) is related to chronic inflammation and currently identified as a risk factor for the occurrence development of endometrial cancer (EC). Pyroptosis new proinflammatory form programmed cell death that plays critical role in progression multiple diseases. However, important pyroptosis high‐glucose (HG)‐related EC underlying molecular mechanisms remain elusive. In present study, transcriptome high‐throughput sequencing revealed significantly higher...
Cryptotanshinone is one of the compounds extracted from root Salvia miltiorrhiza Bunge. Unlike other tanshinones, only a small number studies have focused on cryptotanshinone for medical treatment. In present study, A549 lung cancer cell line and xenograft models human tumors were used to assess anti‑cancer effect cryptotanshinone. The cancer, including growth inhibition, cycle arrest apoptosis factors, identified in vitro, inhibition tumor formation, improvement body condition as well...
Dysfunction of early endothelial progenitor cells (EPCs) is responsible for impaired repair capacity after arterial injury in patients with hypertension. Here, we hypothesized that diminished signaling CXC chemokine receptor 7 (CXCR7) contributes to the reduced EPC functions, and enhanced CXCR7 expression restores capacities EPCs from hypertensive patients. was significantly when compared healthy subjects. Meanwhile, phosphorylation p38 mitogen-activated protein kinase, a downstream CXCR7,...
Although hyperaldosteronemia exerts detrimental impacts on vascular endothelium in addition to elevating blood pressure, the effects and molecular mechanisms of early endothelial progenitor cell (EPC)-mediated repair after arterial damage are yet be determined. The aim this study was investigate capacity EPCs from hypertensive patients with primary (PHA). In vivo PHAs (n=20), age- pressure-matched essential hypertension age-matched healthy subjects (n=20) evaluated by transplantation into a...
Abstract The formation of Mg‐/Alkali‐suites represents the most pronounced and oldest process in magmatic evolution Moon. Fragments these rocks have been identified among samples collected by almost all lunar missions. In addition, remote observations indicate widespread distribution on However, remain restricted to locations around south‐eastern boundary Procellarum KREEP Terrane (PKT), limiting ability confirm information provided investigate relationships between different parts An...
Abstract It is desirable to have a biomarker which can facilitate low‐dose CT in diagnosis of early stage lung cancer. CTAPIII/CXCL7 reported be potential for In this study, we investigated the serum level patients at different cancer and diagnostic efficacy NSCLC. The plasma was assayed by ELISA. CEA, SCCAg, Cyfra211 were measured using commercial chemiluminescent microparticle immunoassay. A total 419 subjects recruited, including 265 NSCLC 154 healthy individuals. randomly assigned...
The Wilms' tumor-associated gene WT1 encodes a tumor suppressor gene, which is implicated in renal differentiation and development of adult urogenital system. 1-associating protein (WTAP) initially identified as nuclear that specifically interacts with both vitro vivo assays. WTAP ubiquitously expressed different tissues various growth periods, its expression involved cell cycle, RNA splicing stabilization, N6-methyladenosine modification, proliferation, apoptosis well embryonic development....
Rapid progression of non-target lesions (NTLs) leads to a high incidence NTL related cardiac events post-PCI, which accounting half the recurrent events. It is important identify risk factors and establish an accurate clinical prediction model for rapid NTLs post-PCI. PCSK9 inhibitors lower LDL-c levels significantly, also show anti-inflammation effect, may have potential reduce We tried test this hypothesis explore mechanisms.
Abstract The endothelial dysfunction induced by oxidized low‐density lipoprotein (ox‐LDL) plays an important role in the pathogenesis of atherosclerosis, which can lead to oxidative stress and inflammation. autophagy process atherosclerosis has drawn increasing attention. human umbilical vein cells (HUVECs), whose Ras‐related C3 botulinum toxin substrate 1 (Rac1) Rac3 was knockdown, were used detect whether possible molecular mechanisms Rac1 for anti‐inflammatory effected downregulation...
Overexpression of T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) on T cells has been observed in smokers. However, whether how galectin-9 (Gal-9)/TIM-3 signal between T-regulatory (Tregs) type 17 helper (Th17) contributes to tobacco smoke-induced airway inflammation remains unclear. Here, we aimed explore the role Gal-9/TIM-3 Tregs Th17 during chronic smoke exposure. phenotype expression TIM-3 CD4
Background: Acute lung injury (ALI) is a progressive syndrome associated with significant mortality in sepsis patients. Neutrophils are key cells the inflammatory response that characterizes ALI. This study was designed to explore effects of hydroxyethyl starch (HES) 130/0.4 (a novel plasma substitute) on pulmonary neutrophil recruitment and ALI rat model induced by cecal ligation puncture (CLP). Methods: Animals were randomly assigned six groups [saline control; CLP saline; HES (7.5, 15 30...
Background Cisplatin remains the mainstay of endometrial cancer (EC) chemotherapy. Wilms’ tumor 1-associated protein (WTAP), playing a critical role in transcriptional and post-transcriptional regulation, has been reported as an oncogene, its expression is elevated multiple types human tumors. Recent evidence shown that increased WTAP also closely related to chemo-resistance. However, specific susceptibility EC cells cisplatin largely unexplored. Methods over-expression depletion cell lines...
The ineffectiveness of anticancer drugs is frequently observed in cancer chemotherapy. resistance tumor cells to various cytotoxic defined as multidrug (MDR). purpose our present study was investigate the inhibitory effects L1EPO synthesized by group on P-glycoprotein (P-gp)-mediated MDR K562/A02 and KBv200 cell lines, which expressed high levels P-gp. Both cytotoxicity compound its ability inhibit were determined sulforhodamine B sodium salt (SRB) assay. Morphologic apoptosis detected...
Human parainfluenza virus type 3 (HPIV3) can cause severe respiratory tract diseases in infants and young children, but no licensed vaccines or antiviral agents are currently available for treatment. Fusing the viral target cell membranes is a prerequisite its entry into host cells directly mediated by fusion (F) protein. Although several domains of F known to have important effects on regulating membrane activity, roles DI-DII linker (residues 369–374) HPIV3 protein fusogenicity still...
Abstract The Pd clusters are widely concerned because of their outstanding catalytic capacity. Here such a candidate 13 cluster with the icosahedron symmetry and multiple active sites is shown. first‐principles calculations reveal that this can maximally catalyze water‐splitting reaction to generate three H 2 from O molecules. geometrical structures reactants, transition states, products optimized, stabilities confirmed by frequency analysis. intrinsic coordinates constructed confirm...
To study the antitumor effect of phlomiol extracted from Phlomis younghusbandii in vivo and vitro. The inhibitory on two kinds human tumor cells proliferation was assayed by MTT method. Transplant models S180 H22 were used. After transplantation, different doses given to mice for 14 days. rates calculated. method used assess T spleen lymphocyte activity NK tumor-bearing with S180. Phlomiol (50-100 mg x L(-1)) inhibited three vitro, a dose-dependent manner (r = 0.989, P < 0.05). (2.5, 5, 10...
(1) Background: In-stent Restenosis (ISR) is a major factor influencing the prognosis and revascularization of target lesions. The plaque composition unclear; therefore, it critical to investigate ISR identify clinical intervention markers. (2) Methods: This study was conducted on 36 patients with drug-eluting stent restenosis. were classified into Low Neutrophil–Lymphocyte Ratio (L-NLR) High (H-NLR) according median NLR level patients. Discrepancies in current information such as baseline...